Pathogenic significance of Klebsiella oxytoca in acute respiratory tract infection.

Power, Joan; Calder, Margaret A.

doi:10.1136/thx.38.3.205

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…Klebsiella spp. can colonize or cause chronic upper and lower respiratory tract infections, septicemia, and severe pneumonia (18)(19)(20)(21)(23)(24)(25), and severe cases of infection were also found in our patients with K. rhinoscleromatis, K. ozaenae, and K. oxytoca.…”

Section: Discussionsupporting

confidence: 51%

Comparison between Patients with Chest Infection due to Klebsiella spp. and Streptococcus pneumoniae

Ishiguro¹,

Uozumi

Yoshioka³

et al. 2020

Intern. Med.

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Objective In Japan, the aging demographic structure is becoming pronounced, and the full-blown graying of society appears not far off, which indicates an increasing population that will require healthcare contact. Klebsiella spp. are major pathogens in healthcare-associated infections, and their importance is increasing. The aim of this study was to clarify the characteristics of Klebsiella spp. chest infections by evaluating the differences in the characteristics of chest infections caused by Klebsiella spp. and pneumoniae. Methods We conducted a retrospective study of consecutive patients hospitalized with pneumonia, lung abscess/necrotizing pneumonia, and empyema due to Klebsiella spp. and S. pneumoniae for 15 years at our institution in Saitama, Japan. Patients Patients with chest infections due to Klebsiella spp. (K group, n=76) and S. pneumoniae (S group, n=446) were included. Results The K group more frequently was male, older, coinfected by Pseudomonas aeruginosa, and had diabetes mellitus, a history of upper digestive system surgery, alcohol drinking habit, a smoking habit, and an impaired premorbid performance status than the S group. The percentages of lung abscesses or necrotizing pneumonia (31.6% vs. 0.9%) and empyema without pulmonary parenchymal shadow (3.9% vs. 0.7%) were higher in the K group than those in the S group. Severity on admission and mortality did not differ between the groups; however, patients in the K group required a longer duration of antibiotics administration and hospital stay than those in the S group. Conclusion Klebsiella spp. chest infections have some marked characteristics when compared with pneumococcal infections, and our results serve to differentiate Klebsiella spp. infection from pneumococcal infection.

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Section: Discussionsupporting

confidence: 51%

Comparison between Patients with Chest Infection due to Klebsiella spp. and Streptococcus pneumoniae

Ishiguro¹,

Uozumi

Yoshioka³

et al. 2020

Intern. Med.

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“…Four of these 11 patients had lobar pneumonia while one had bronchopneumonia, five had acute exacerbations of chronic bronchitis and one had an acute respiratory tract infection superimposed on cryptogenic fibrosing alveolitis. The authors advocated that treatment was indicated whenever this organism was isolated from the clinical specimens [15].…”

Section: Discussionmentioning

confidence: 99%

Chronic Pneumonia Due to Klebsiella oxytoca Mimicking Pulmonary Tuberculosis

Gera

Roshan

Varma-Basil

et al. 2015

Advances in Respiratory Medicine

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Klebsiella species infrequently cause acute community acquired pneumonia (CAP). The chronic form of the disease caused by K. pneumoniae (Friedlander's bacillus) was occasionally seen in the pre-antibiotic era. K. oxytoca is a singularly uncommon cause of CAP. The chronic form of the disease caused by K. oxytoca has been documented only once before. A 50-year-old immunocompetent male smoker presented with haemoptysis for 12 months. Imaging demonstrated a cavitary lesion in the right upper lobe with emphysematous changes. Sputum stains and cultures for Mycobacterium tuberculosis were negative. However, three sputum samples for aerobic culture as well as bronchial aspirate cultured pure growth of K. oxytoca. A diagnosis of chronic pneumonia due to K. oxytoca was established and with appropriate therapy, the patient was largely asymptomatic. The remarkable clinical and radiological similarity to pulmonary tuberculosis can result in patients with chronic Klebsiella pneumonia erroneously receiving anti-tuberculous therapy.

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“…16 Klebsiella oxytoca has not previously been described as a pathogen in this country. It was considered the etiologic agent of respiratory tract infections in ten hospitalized patients in Edinburgh 6 with similar clinical pictures of an acute Klebsiella pneumoniae. Bacteremia was identified in one patient.…”

Section: Discussionmentioning

confidence: 99%

Klebsiella oxytoca Isolates in a General Hospital

et al. 1985

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Primary infections caused by Klebsiella species are uncommon, but the organism is an important nosocomial pathogen. We report the predisposing factors, clinical features and outcome of 44 hospitalized patients in whom Klebsiella oxytoca was isolated. Twenty-one (48%) isolates were community-acquired and 23 (52%) were considered nosocomial in origin. Most of the patients were elderly males with serious underlying diseases. There were significant differences between those patients who acquired Klebsiella oxytoca in the hospital and in the community. Nosocomially acquired organisms were associated with a higher mortality (52% vs. 24%) (p<0.05), a higher incidence of infection vs. colonization (83% vs. 57%) (p<0.05), and a higher percentage of cases of pneumonia (43% vs. 19%) (p<0.05). The clinical features, the hospital service and the patients' underlying diseases were similar when patients who died and those who survived were compared. Patients who died were exposed to antibiotics more often prior to the positive culture with K. oxytoca (p<0.05). K. oxytoca is a significant pathogen in hospitalized elderly patients. It is likely to cause infections, especially pneumonia, and carry a high mortality. The organism can become endemic within the hospital setting with continued carriage and nosocomial spread.

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Pathogenic significance of Klebsiella oxytoca in acute respiratory tract infection.

Cited by 14 publications

References 7 publications

Comparison between Patients with Chest Infection due to <i>Klebsiella</i> spp. and <i>Streptococcus pneumoniae</i>

Comparison between Patients with Chest Infection due to <i>Klebsiella</i> spp. and <i>Streptococcus pneumoniae</i>

Chronic Pneumonia Due to Klebsiella oxytoca Mimicking Pulmonary Tuberculosis

Klebsiella oxytoca Isolates in a General Hospital

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