Pathogenicity and virulence of monkeypox at the human-animal-ecology interface

Islam, Mazharul; Dutta, Pronesh; Rashid, Rijwana; Jaffery, Syed Shariq; Islam, Ariful; Farag, Elmoubashar; Zughaier, Susu M.; Bansal, Devendra; Hassan, Mohammad Mahmudul

doi:10.1080/21505594.2023.2186357

Cited by 19 publications

(17 citation statements)

References 96 publications

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“…Es existieren zwei genetische Gruppen des Mpox-Virus, welche sich sowohl in der Klinik der durch sie verursachten Erkrankung als auch in ihrem geografischen Ursprung unterscheiden [4,5]: ▪ die Gruppe I (vormals zentralafrikanisch) und ▪ die Gruppe II (vormals westafrikanisch). Nachdem im Mai 2022 in Großbritannien bei einem Reiserückkehrer aus Nigeria erstmals eine Infektion mit Mpox (vormals Affenpocken, Monkeypox) diagnostiziert wurde, wurden wenig zeitversetzt auch die ersten Fälle in Deutschland gemeldet.…”

Section: Erregerunclassified

Erregerlexikon: Mpox-Viren

Wagner,

Boesecke,

Spinner

2024

Krankenhaushygiene up2date

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Section: Erregerunclassified

Erregerlexikon: Mpox-Viren

Wagner,

Boesecke,

Spinner

2024

Krankenhaushygiene up2date

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“…Contact tracing is difficult because some patients had sex with multiple anonymous partners. Attention among healthcare providers in nonendemic countries must be paid [70]. In addition, the vaccine acceptance of MPX remains a challenge, which is like during the COVID-19 pandemic.…”

Section: Challenges and One Health Strategymentioning

confidence: 99%

"Monkeypox: Re-Emerging Infectious Disease and One Health Strategy"

Wang

2024

BJSTR

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World Health Organization (WHO) has announced the monkeypox (MPX) epidemic as a global public health emergency due to its re-emergence, remarkable increase in the number of MPX cases worldwide, and its potential spread. This paper introduces the symptoms, complications, and features of MPX; its transmission, diagnosis and testing, vaccines, and treatment; MPX and sexually transmitted diseases, especially the human immunodeficiency virus (HIV); possible natural hosts or reservoirs of the monkeypox virus (MPXV). A useful tool for MPX and surgical safety recommendations are presented. The challenges in fighting the MPX epidemic, the One Health strategy, and future research are discussed.

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“…), and southern opossums ( Didelphis marsupialis ) [ 12 ]. In nature, the virus has been isolated from wild animals, like the sooty mangabey (Cercocebus atys) [ 30 ] and rope squirrel (Funisciurus anaerythrus) [ 31 , 32 ]. The origin of the MPXV remains unclear, as the natural reservoir remains unidentified, but some data suggest that African rodents [ 33 ] may be responsible for maintaining the virus’ circulation in nature.…”

Section: Animal Reservoirsmentioning

confidence: 99%

Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies

et al. 2023

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Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular–pustular skin lesions. However, the differential diagnosis between smallpox and monkeypox is that smallpox does not cause lymphadenopathy but monkeypox generates swelling in the lymph nodes. Since the eradication of smallpox, MPXV has been identified as the most common Orthopoxvirus to cause human disease. Despite MPXV being endemic to certain regions of Africa, the current MPXV outbreak, which began in early 2022, has spread to numerous countries worldwide, raising global concern. As of the end of May 2023, over 87,545 cases and 141 deaths have been reported, with most cases identified in non-endemic countries, primarily due to human-to-human transmission. To better understand this emerging threat, this review presents an overview of key aspects of MPXV infection, including its animal reservoirs, modes of transmission, animal models, epidemiology, clinical and immunological features, diagnosis, treatments, vaccines, and prevention strategies. The material presented here provides a comprehensive understanding of MPXV as a disease, while emphasizing the significance and unique characteristics of the 2022 outbreak. This offers valuable information that can inform future research and aid in the development of effective interventions.

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Pathogenicity and virulence of monkeypox at the human-animal-ecology interface

Cited by 19 publications

References 96 publications

Erregerlexikon: Mpox-Viren

Erregerlexikon: Mpox-Viren

"Monkeypox: Re-Emerging Infectious Disease and One Health Strategy"

Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies

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