Pathogenicity of the newly emerged Lagovirus europaeus GI.2 strain in China in experimentally infected rabbits

Chen, Mengmeng; Fan, Zhiyu; Hu, Bo; Song, Yanhua; Hou-jun,; Qiu, Rulong; Weifeng,; Xu, Wenwen; Wang, Fang

doi:10.1016/j.vetmic.2021.109311

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…Titration of inoculants is necessary in order to more accurately compare the pathogenicity of two lagoviruses under the same conditions. Pathological changes and viral load after GI.2 infection have been widely reported elsewhere [16][17][18][19] . In contrast to several previous studies, GI.1 and GI.2 Chinese strains were used to infect rabbits of three different ages.…”

Section: Discussionmentioning

confidence: 78%

“…Pathological changes and viral load after GI.2 infection have been widely reported elsewhere 16 – 19 . In contrast to several previous studies, GI.1 and GI.2 Chinese strains were used to infect rabbits of three different ages.…”

Section: Discussionmentioning

confidence: 83%

“…There had been many previous studies dealing with the pathogenicity of GI.1 or GI.2 [16][17][18][19] , and pointing out some differences in the pathogenicity of the two viruses, but these studies were not all conducted under the same conditions, so the results are not directly comparable. Our study reports a systematic comparison, control the relevant parameters of GI.1/GI.2 challenge experiment uniformly (both viruses simultaneously, rabbit age groups, same virus dose and inoculation route).…”

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confidence: 99%

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The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay

Zhou

Jiang

et al. 2022

Sci Rep

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Lagovirus europaeus GI.1 belongs to Lagovirus in the Caliciviridae family. GI.1 causes an acute, septic, and highly lethal disease in rabbits. Lagovirus europaeus GI.2, a new variant of GI.1, has caused explosive mortality in rabbits of all ages in Sichuan Province, China. To explore the differences in pathogenicity of rabbits infected with GI.1/GI.2, we investigated the virulence and disease progression of a naturally occurring GI.1/GI.2 in 4-week-old, 13-week-old, and 25-week-old New Zealand White laboratory rabbits after GI.1/GI.2 infection. Objective measures of disease progression were recorded using continuous body-temperature monitoring. We observed the kittens were infected with GI.2 during the most urgent course of the disease, and GI.1 was not lethal to kittens. We found that the target organ of both GI.1 and GI.2 was the liver, but the disease course of the two viruses was differed. Our study enriches the research on the pathogenicity of GI.1 and GI.2 under the same conditions.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

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The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay

Zhou

Jiang

et al. 2022

Sci Rep

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“…The pathological changes and virus load after RHDV2 infection have been widely reported elsewhere [19,20,21,22] . In contrast to several previous studies, RHDV and RHDV2 Chinese strains were used to infect rabbits of three ages respectively.…”

Section: Discussionmentioning

confidence: 78%

The Pathogenicity comparison of RHDV and RHDV2 in China by using relative quantitative assay

Zhou

Jiang

et al. 2022

Preprint

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Rabbit hemorrhagic disease virus (RHDV) belongs to Lagovirus in the Caliciviridae family. RHDV is an acute, septic, and highly lethal disease in rabbits. RHDV2, a new variant of RHDV, caused explosive mortality in rabbits of all ages in Sichuan Province, China. To explore the differences in pathogenicity of rabbits infected with RHDV2/RHDV, we investigated the virulence and disease progression of a naturally occurring RHDV/RHDV2 in 4-week-old, 13-week-old, and 25-week-old New Zealand White laboratory rabbits after RHDV/RHDV2 infection. Objective measures of disease progression were recorded through a continuous body temperature monitor. We observed the kittens were infected with RHDV2 in the most urgent course of the disease, and RHDV is not lethal to kittens. We found that the target organ of both RHDV and RHDV2 was the liver, but the disease course of the two viruses was different. Our study enriches the research on the pathogenicity of RHDV2 and RHDV under the same conditions. We carried out studies on the infection of RHDV2 and RHDV in rabbits of different ages under the same conditions, which enriched the study on the pathogenicity of RHD.

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“…Te RHDV GI.2 caused signifcant declines in European rabbit abundance following its emergence in the Iberian Peninsula and elsewhere [21,22]. While the pathogenicity of RHDV GI.2 in European rabbits was thoroughly studied through experimental infections [19,23], its epidemiology in wild populations in its native range is still largely unknown, particularly for the southwestern Iberian subspecies (Oryctolagus cuniculus algirus).…”

Section: Introductionmentioning

confidence: 99%

High Mortality of Wild European Rabbits during a Natural Outbreak of Rabbit Haemorrhagic Disease GI.2 Revealed by a Capture-Mark-Recapture Study

Jiménez‐Ruiz

Rafael

Coelho

et al. 2023

Transboundary and Emerging Diseases

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Rabbit haemorrhagic disease virus (RHDV) GI.2 has caused significant declines in the abundance of wild European rabbits (Oryctolagus cuniculus), contributing to the species being recently classified as “endangered” in its native range. The epidemiology of this virus is still poorly understood despite its relevance for domestic and wild rabbits. During a longitudinal capture-mark-recapture (CMR) study of wild Iberian rabbits, O. c. algirus, in a semiextensive breeding enclosure, an outbreak of RHDV GI.2 took place in January-February 2022, allowing us to estimate key epidemiological parameters of a natural outbreak. From April 2021 to July 2022, 340 rabbits were captured 466 times and individually identified, and some were vaccinated against myxoma virus (MYXV) and/or RHDV GI.2. Sera were collected and tested for IgG specific for MYXV and RHDV GI.2, and data were analyzed using multievent CMR models. During six weeks in January-February 2022, an estimated 81.0% (CI95 77.1–84.3%) of the population died. Intensive aboveground searches could recover 189 carcasses (50.5% of the estimated mortality, CI95 41.8–63.4%), with RHDV GI.2 detected in 6/7 tested. Apparent RHDV GI.2 seroprevalence rose from 15.4% (CI95 8.0–27.5%) in January 2022 to 87.9% (CI95 72.7–95.2%) in February 2022. The apparent mortality of RHDV GI.2-seropositive rabbits during the outbreak was estimated as null, while for seronegative rabbits, it was 76.0% (CI95 53.8–90.3%). Among the seronegative rabbits, mortality was higher in unvaccinated (100%) than in recently vaccinated (60.0 ± 16.6%) and in females (100%) than in males (52.0 ± 17.1%). Infected carcasses in the burrows might explain the medium-term disease persistence in the population following the outbreak. Rabbits with antibodies at the cutoff for seropositivity were fully protected from fatal infection. Females had a higher fatality rate than males, underscoring the impact of RHDV GI.2 on the population dynamics of this endangered species.

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Pathogenicity of the newly emerged Lagovirus europaeus GI.2 strain in China in experimentally infected rabbits

Cited by 5 publications

References 35 publications

The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay

The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay

The Pathogenicity comparison of RHDV and RHDV2 in China by using relative quantitative assay

High Mortality of Wild European Rabbits during a Natural Outbreak of Rabbit Haemorrhagic Disease GI.2 Revealed by a Capture-Mark-Recapture Study

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