Pathologic Changes of Aorta and Coronary Arteries of Mice Infected with Coxsackie B4 Virus

Burch, George E.; Tsui, C. Y.; Harb, Joseph M.

doi:10.3181/00379727-137-35641

Cited by 35 publications

(4 citation statements)

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“…Enterovirus infections have long been shown to be associated with myocarditis [22]. Animal experiments have demonstrated that enterovirus infection may cause changes in coronary capillaries and arteries [23]. Enterovirus infections were later shown to be associated with acute myocardial infarction in uncontrolled [24, 25] and controlled clinical series [26].…”

Section: Discussionmentioning

confidence: 99%

Enterovirus, mycoplasma and other infections as predictors for myocardial infarction

Reunanen

Roivainen

Kleemola

et al. 2002

Journal of Internal Medicine

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Abstract. Reunanen A, Roivainen M, Kleemola M, Saikku P, Leinonen M, Hovi T, Knekt P, Leino A, Aromaa A (National Public Health Institute, Helsinki and Oulu; Social Insurance Institution, Turku; University Hospital, Turku, Finland). Enterovirus, mycoplasma and other infections as predictors for myocardial infarction. Journal of Intern Med 2002; 252: 421-429.Objectives. To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline. Design. A case-control study nested within a prospective population study. Subjects. The study cases included 441 men 45-64 years old with nonfatal myocardial infarction or coronary death within a mean follow-up time of 10 years. A total of 165 men had already signs of heart disease at baseline, whilst 276 were apparently healthy at the beginning of the study. Two controls for each case were matched for age, heart disease status and place of residence. Antibodies against enterovirus, Mycoplasma pneumoniae, Chlamydia pneumoniae, cytomegalovirus and adenovirus were determined. Results. Men without reported baseline heart disease, but not those with heart disease, showing the highest quartile of antibodies to enterovirus and mycoplasma or increased levels of immune complex-bound antibodies to chlamydia had a significantly higher risk of coronary events than men with lower level of antibodies. The increased risk demonstrated in men with high levels of antibodies to enterovirus and mycoplasma remained significant after adjustment for other antibodies, acutephase reactant and conventional risk factors. Serological evidence of infection by multiple agents was also significantly associated with coronary events. Conclusions. Serological evidence for several infectious agents is associated with the risk of coronary heart disease, but only in men without baseline history of heart disease.

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Section: Discussionmentioning

confidence: 99%

Enterovirus, mycoplasma and other infections as predictors for myocardial infarction

Reunanen

Roivainen

Kleemola

et al. 2002

Journal of Internal Medicine

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“…A number of investigators have described the effects of viral infection on endothelial cell function and integrity. These include the findings of viral particles within endothelial cells (35), as well as morphologic changes within these cells (36)(37)(38). By the fourth day following parvovirus infection, cushion-like swellings of the endothelial cells were observed which produced focal narrowing of the vascular lumen.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the Liver

et al. 1983

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Mouse hepatitis virus type 3 infection results in strain-dependent liver disease. The effects of mouse hepatitis virus type 3 on the microcirculation of the liver in both fully susceptible (Balb/cJ) and fully resistant (A/& mice were studied. In Balb/cJ mice, 6 to 12 h r following infection, abnormalities in liver blood flow were observed which consisted of granular blood flow in both terminal hepatic and terminal portal venules. In addition, sinusoidal microthrombi were present predominantly in periportal areas. By 24 to 48 hr, liver cell edema and small focal lesions were prominent. At 48 hr, thrombi and hepatocellular necrosis were widespread, and blood was shunted from damaged areas into patent sinusoids. In sharp contrast to these abnormal findings, normal streamlined blood flow was present in the resistant A/J animals at all time points following infection. Since large amounts of virus were demonstrated by immunofluorescene in and by recovery and growth from livers of both resistant and susceptible strains, the presence of the virus per se cannot explain the abnormalities observed.

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“…This is the first report to discuss a coronary artery spasmobserved in the acute phase. In an animal study, Burch et al demonstrated coronary arteritis by Coxsackle B4 virus (12). Ferguson et al suggested that vasoactive substances released from platelet aggregates which were caused by coronary arteritis produced coronary spasm (4).…”

Section: Casementioning

confidence: 99%

Coronary Artery Spasm Demonstrated by Coronary Angiography in a Patient with Acute Myocarditis Resembling Acute Myocardial Infarction; A Case Report.

et al. 1991

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A 59-year-old male with acute myocarditis presenting symptoms resembling acute myocardial infarction underwent urgent coronary angiography due to difficulties in determining a diagnosis. Coronary artery spasm was demonstrated in the proximal right and left anterior descending coronary arteries. The spasm varied from time to time and lesion to lesion. But no fixed occluded lesion was observed. Predischarge coronary angiography showed no abnormal findings. Histological findings of the biopsy specimen from the left ventricle were consistent with myocarditis. The findings of this case indicate that a coronary artery spasm mayaggravate the myocardial damage occurring in acute myocarditis. Urgent coronary angiography and endomyocardial biopsy are important to makethe diagnosis of myocarditis in patients presenting symptomsresembling acute myocardial infarction.

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Pathologic Changes of Aorta and Coronary Arteries of Mice Infected with Coxsackie B4 Virus

Cited by 35 publications

References 0 publications

Enterovirus, mycoplasma and other infections as predictors for myocardial infarction

Enterovirus, mycoplasma and other infections as predictors for myocardial infarction

The Effect of Mouse Hepatitis Virus Infection on the Microcirculation of the Liver

Coronary Artery Spasm Demonstrated by Coronary Angiography in a Patient with Acute Myocarditis Resembling Acute Myocardial Infarction; A Case Report.

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