Pathological Analysis of the Ruptured Vascular Wall of Hypoperfusion-induced Abdominal Aortic Aneurysm Animal Model

Kugo, Hirona; Zaima, Nobuhiro; Tanaka, Hiroki; Hashimoto, Keisuke; Miyamoto, Chie; Sawaragi, Ayaka; Urano, Tetsumei; Unno, Naoki; Moriyama, Tatsuya

doi:10.5650/jos.ess16219

Cited by 34 publications

(31 citation statements)

References 12 publications

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“…In addition, distinct hyperlipidemia was not observed by the administration of the high-fat diet. These results are consistent with our previous reports, which suggested that serum triglyceride and serum total cholesterol levels in a hypoperfusion-induced animal model were not correlated with the AAA diameter or the number of adipocytes in the vascular wall [17,19]. It was noted that the high-fat diet was not affected by the appearance of adipocytes in the neck (normal aortic diameter region) vascular wall (Fig.…”

Section: Discussionsupporting

confidence: 93%

“…In patients with AAA and in a hypoperfusion-induced AAA animal model, it was shown that the AAA diameter was not correlated with serum triglyceride levels or serum total cholesterol levels [17,19]. These results suggest that the development of AAA is not associated with hyperlipidemia directly, but instead with adipocytes in the vascular wall [17,19]. We speculated that the dietary condition could play a role in the development and rupture of AAA.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model

Hashimoto

Kugo

Tanaka³

et al. 2018

J Vasc Res

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Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infrarenal aorta. Most cases of AAA remain asymptomatic until rupture, and the mortality rate of patients with AAA rupture is very high. Currently, the relation between dietary habits and AAA development remains unknown. In this study, we evaluated the effects of a high-fat diet on the development of AAA in a vascular hypoperfusion-induced animal model. The risk of AAA rupture and AAA diameter in the high-fat group significantly increased compared with those in the control group. The number and size of adipocytes in the vascular wall in the high-fat group significantly increased as compared with those in the control group. Additionally, the collagen-positive sections in the areas with adipocytes significantly decreased as compared with those without adipocytes. The protein levels of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-12, and macrophage-positive areas in the parts with adipocytes also significantly increased as compared with those without adipocytes. These data suggested that AAA rupture risk increased through accelerating chronic inflammation due to the accumulation of adipocytes in the vascular wall in the high-fat group.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model

Hashimoto

Kugo

Tanaka³

et al. 2018

J Vasc Res

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“…The intergroup differences in aortic diameter and dilation ratio were insignificant. The abnormal appearance of adipocytes in the vascular wall can reportedly induce AAA rupture 13,14 . In this study,…”

Section: Discussionmentioning

confidence: 99%

“…We evaluated adipocytes in the adventitia, as we previously reported inducing AAA rupture by adipocytes in the adventitia 13,14 …”

Section: Adipocytes In the Vascular Wallmentioning

confidence: 99%

“…We further demonstrated, using a newly developed hypoperfusion-induced animal model, that vascular wall hypoperfusion caused AAA development 12 . It was recently demonstrated that the abnormal appearance of adipocytes in the vascular wall can induce AAA rupture 13,14 . A subsequent study indicated that a high-fat diet induced AAA rupture by increasing the number of adipocytes in the vascular wall 15 .…”

Section: Introductionmentioning

confidence: 99%

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