Pathological and histological findings associated with the feline lungworm Troglostrongylus brevior

Giannelli, Alessio; Passantino, Giuseppe; Ramos, Rafael Antonio Nascimento; Presti, Giuseppe Lo; Lia, Riccardo Paolo; Brianti, Emanuele; Dantas‐Torres, Filipe; Papadopoulos, Elias; Otranto, Domenico

doi:10.1016/j.vetpar.2014.05.020

Cited by 27 publications

(36 citation statements)

References 9 publications

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“…A field trial study was conducted in three geographical sites of Italy, (i.e., Messina, Sassari and Bari), where the occurrence of feline lungworm infections had been previously reported (Brianti et al, 2012;Annoscia et al, 2014;Giannelli et al, 2014a;Tamponi et al, 2014). From May to September 2014, client owned cats, which had regular access to the outdoor environment, were clinically examined.…”

Section: Prevalence Of Endoparasite Infections In Cats At the Enrolmentmentioning

confidence: 99%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®, Merial) has been released for the treatment of a variety of feline parasitic infections. The present study reports the efficacy of this spot-on in treating cats naturally infected by feline lungworms. Client owned cats (n=191) were enrolled from three geographical areas of Italy and faecal samples were examined by floatation and Baermann techniques. Twenty-three individuals were positive for L1 of A. abstrusus (n=18) or T. brevior (n=3) or for both species (n=2) and they were topically treated with Broadline®. Seventeen of them were also concomitantly infected by other parasites. Four weeks after treatment, faecal samples were collected and examined to assess the efficacy of a single administration of the product. Based on lungworm larvae counts, the efficacy of the treatment was 90.5% or 100% for A. abstrusus or T. brevior, respectively. Cats released significantly lower amounts of lungworm larvae after treatment compared to pre-treatment (p<0.0001). All but three cats were negative for other nematodes after treatment and all cats recovered from respiratory signs. Results of this study indicate that a single administration of the topical combination fipronil, (S)-methoprene, eprinomectin and praziquantel is effective and safe for the treatment of A. abstrusus and/or T. brevior infections in cats living under field conditions.

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Section: Prevalence Of Endoparasite Infections In Cats At the Enrolmentmentioning

confidence: 99%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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“…The morphological identification was also confirmed by the molecular amplification and sequencing of a partial 18S ribosomal RNA (rRNA) gene sequence (1,708 bp). The nucleotide sequence (KM035792), examined by BLAST tool, displayed 99 % homology with the sequence (GU946678) of O. rostratus from a bobcat (L. rufus) deposited in GenBank (Jefferies et al 2010).…”

Section: Resultsmentioning

confidence: 99%

“…Anafilaroides rostratus) (Strongylida: Filaridae) have been considered for long time of minimal importance (Anderson 2000;Bowman et al 2002;Traversa and Di Cesare 2013). Recently, cases of infection by T. brevior, alone or associated with A. abstrusus in domestic cats have been reported in Italy (Annoscia et al 2014;Brianti et al 2012;Di Cesare et al 2014;Giannelli et al 2014;Tamponi et al 2014) and Spain (Jefferies et al 2010), indicating that these infections have been most likely misdiagnosed or overlooked in the past .…”

Section: Introductionmentioning

confidence: 99%

Feline lungworm Oslerus rostratus (Strongylida: Filaridae) in Italy: first case report and histopathological findings

et al. 2014

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Oslerus rostratus syn. Anafilaroides rostratus (Strongylida: Filaroididae) is a metastrongyloid transmitted by snails, which localizes in peri-bronchial tissues and in the lung parenchyma of wild as well as domestic cats. In Europe, this nematode has been reported only on two occasions, being diagnosed in cats from Majorca Island and in northern Spain. Here, we describe a case of O. rostratus infection in a necropsied 4-year-old cat in Sicily (southern Italy). At the inspection of lungs, slender and greyish nematodes (four females and two males) were found embedded in the peri-bronchial tissues and in the bronchial walls. Parasites were morphological and molecularly identified as O. rostratus, with their 18S sequences being identical among them and showing a high homology (99%) with those available in public databases. At the histology, nematodes were encapsulated in a pseudo-cystic formation surrounded by an interstitial inflammatory process and fibrous tissue. Lung lesions were mainly represented by peri-luminal fibrosis, hyperplasia and hypertrophy of the bronchial mucosa and glands, respectively. This first record of O. rostratus infection from Italy indicates that this parasite should be included in the differential diagnosis of feline of lungworm infection.

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“…2,16,36 Single cases of Troglostrongylus species infection were recently reported in cats from Ibiza (Spain), central and southern Italy and Crete (Greece). 9,12,13,15,19,20,29,50 The first epidemiologi- cal data on T brevior in domestic cats were recently provided in Sardinia (Italy) where 6.5% of a sample of 107 cats tested positive compared with 25.2% that tested positive for A abstrusus, 14 confirming that Troglostrongylus is not a negligible lungworm of domestic cats.…”

Section: Life Cycle and Transmissionmentioning

confidence: 99%

Lungworm disease in cats

Pennisi

Hartmann²,

Addie³

et al. 2015

Journal of Feline Medicine and Surgery

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Pathological and histological findings associated with the feline lungworm Troglostrongylus brevior

Cited by 27 publications

References 9 publications

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Feline lungworm Oslerus rostratus (Strongylida: Filaridae) in Italy: first case report and histopathological findings

Lungworm disease in cats

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