Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease

Sogabe, Yuka; Miyatani, Katsuya; Goto, Rieko; Ishii, Gengo; Ohshima, Kohichi; Sato, Yasuharu

doi:10.1007/s10384-012-0170-3

Cited by 41 publications

(21 citation statements)

References 17 publications

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“…However, it is now known that IgG4-related ophthalmic lesions are not limited to the lacrimal glands but may also manifest diffusely in the orbit and in diverse ocular tissues such as the extraocular muscles, orbital nerve (trigeminal nerve branch), and eyelid [13]. In particular, enlargement of the infraorbital or supraorbital nerve, or both, is frequently observed in this disease [13][14][15].…”

Section: History Of Igg4-related Diseasementioning

confidence: 99%

Diagnostic criteria for IgG4-related ophthalmic disease

2014

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Immunoglobulin G4 (IgG4)-related disease is a novel clinical entity characterized by infiltration of IgG4-immunopositive plasmacytes and elevated serum IgG4 concentration accompanied by enlargement of and masses in various organs, including the lacrimal gland, salivary gland, and pancreas. Recent studies have clarified that conditions previously diagnosed as Mikulicz disease as well as various types of lymphoplasmacytic infiltrative disorders of the ocular adnexa are consistent with a diagnosis of IgG4-related disease. Against this background, the diagnostic criteria for IgG4-related ophthalmic disease have recently been established, based on both the clinical and the histopathologic features of the ocular lesions. This article reviews these new criteria with reference to the comprehensive diagnostic criteria for IgG4-related disease for all systemic conditions reported in 2012.

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Section: History Of Igg4-related Diseasementioning

confidence: 99%

Diagnostic criteria for IgG4-related ophthalmic disease

2014

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“…Extraocular muscles [6,10,17,36] and infraorbital and supraorbital nerve enlargements [8,9,17,[36][37][38] are also frequently diagnosed in cases of IgG4-related ophthalmic disease. Inflammatory lesions in adipose tissue [8] surrounding the optic nerve [17,34], and even in the lacrimal drainage system [39,40], occur less frequently.…”

Section: Discussionmentioning

confidence: 99%

A prevalence study of IgG4-related ophthalmic disease in Japan

2013

Jpn J Ophthalmol

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“…The nerve fascicles are intact and the disease appears to involve the epineurium principally. 27 Fibrosis is not usually a feature of nerve involvement.…”

Section: Ocular Adnexal Igg4-rdmentioning

confidence: 99%