Pathological lesions associated with schistosoma mansoni infection in man

Cheever, Allen W.; Andrade, Zilton A.

doi:10.1016/0035-9203(67)90125-3

Cited by 140 publications

(74 citation statements)

References 15 publications

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“…Nearly all persons with lethal chronic infections have Symmers' fibrosis and most of these die from bleeding esophageal varices. Others with Symmers' fibrosis die with chronic hepatocellular failure and a smaller number from complications of pulmonary hypertension or glomerulonephritis (Cheever & Andrade 1967) but death from schistosomiasis in patients without Symmers' fibrosis is very uncommon.…”

Section: Causes Of Deathmentioning

confidence: 99%

“…There has long been controversy about the association of human hepatocellular carcinomas and schistosome infections, but S. mansoni infection is apparently not associated with hepatoma in man (Cheever & Andrade 1967). Hepatomas are infrequently seen in infected animals but infected mice given low doses of some carcinogens developed hepatomas much more frequently than did mice given the carcinogen alone (Domingo et al 1967, Kakizoe 1985.…”

Section: Interaction Of Schistosomiasis With Other Diseasesmentioning

confidence: 99%

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Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

123

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Section: Causes Of Deathmentioning

confidence: 99%

Section: Interaction Of Schistosomiasis With Other Diseasesmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

123

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“…Depending on the course of infection and patient symptoms, schistosomiasis mansoni can progress to a severe life-threatening form of disease (2). Indeed, the highest mortality in human schistosomiasis mansoni occurs in the minority of people who develop hepatosplenic schistosomiasis, characterized by periportal fibrosis, portosystemic shunts, and hematemesis (3,4). In the murine model of Schistosoma mansoni infection, adult female worms begin laying eggs 5-6 wk postinfection.…”

mentioning

confidence: 99%

IL-13 receptor α 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis

Mentink‐Kane

Cheever

Thompson

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

126

124

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An important feature of many chronic parasitic infections is the ability of the invading pathogen and host to establish a compromise, which ensures successful parasitism without killing the infected host. For many helminth infections, down-modulating the immune response is critical because persistent inflammation can become more damaging to the host than the invading pathogen itself. Such is the case with schistosomiasis mansoni, where chronic granulomatous inflammation in the liver causes portal hypertension, porto-pulmonary shunting, bleeding from collateral bypass vessels, and eventual death if not suppressed effectively. CD4 ؉ T helper type 2 cells (Th2) (secreting IL-4, IL-5, and IL-13) characterize the host response after Schistosoma mansoni infection, and recent studies have identified IL-13 as the principal mediator of hepatic fibrosis. Here, we show that the IL-13 receptor ␣ 2 (IL-13R␣2) is a critical mediator of immune down-modulation, identifying the receptor as a life-sustaining off signal for chronic and pernicious inflammation in schistosomiasis.

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“…In contrast, different types of papillary, mucinous and tubular adenocarcinoma were observed in colonic carcinoma patients. Cheever and Andrade (1967) and Chassot et al (1998) showed that schistosomiasis-related intestinal polyps are frequently seen in Egyptian cases of intestinal schistosomiasis, which is different compared to most other endemic areas. Colonic involvement has been demonstrated to be meagre in Brazilian cases, rarely exhibiting polyps, and with no signs of a particular relationship with colonic cancer.…”

Section: Resultsmentioning

confidence: 96%

“…In China, a high incidence of colorectal cancer in regions with endemic S. japonicum was recorded, where patients with chronic Schistosomiasis japonica have a more than three times greater risk of developing colon cancer than those with no previous exposure to schistosomal infection (Salim et al 2010). Therefore, the difference in parasite strains, intensity of infection, concomitant infections (including S. haematobium) and environmental conditions may be important in determining the varying patterns of the disease (Cheever & Andrade 1967).…”

Section: Resultsmentioning

confidence: 99%