Pathological Mechanisms Induced by TRPM2 Ion Channels Activation in Renal Ischemia-Reperfusion Injury

Khanahmad, Hossein; Mirbod, Seyedeh Mahnaz; Karimi, Farzaneh; Kharazinejad, Ebrahim; Owjfard, Maryam; Najaflu, Malihe; Tavangar, Mehrsa

doi:10.1007/s11033-022-07836-w

Cited by 9 publications

(4 citation statements)

References 88 publications

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“…It has been confirmed that circulation anomalies can lead to kidney and liver ischemia-reperfusion injury, followed by pulmonary inflammatory response [18,19]. Experimental studies have shown that ischemic acute kidney injury (AKI) is associated with increased pulmonary vascular permeability, cellular apoptosis, and alveolar hemorrhage [20]. Changes in lung texture are often thought to be pneumonia by respiratory physicians, but in reality, it may represent an inflammatory response following multiple organ injuries in severe AMI patients.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of perioperative continuous renal replacement therapy for percutaneous coronary intervention in severe acute myocardial infarction patients

et al. 2023

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This retrospective study aimed to evaluate the safety and efficacy of continuous renal replacement therapy (CRRT) during percutaneous coronary intervention (PCI) in patients with severe acute myocardial infarction (AMI). The study analyzed data from 945 AMI patients hospitalized between January 2016 and December 2017, out of which 21 patients underwent perioperative CRRT for PCI. We assessed the baseline characteristics of severe AMI patients before and after CRRT and examined the effect of CRRT on cardiac, renal, and liver function, as well as other indicators. The heart rate of patients undergoing CRRT was significantly lower at 24 h and 48 h after CRRT than before CRRT (p=0.038). There was a moderate but not significant decrease in the mean systolic blood pressure or diastolic blood pressure (p>0.05). Importantly, we found that significantly more patients showed Killip class I-II and significantly improved cardiac function after CRRT (23.8% vs. 57.1%, p=0.001). The levels of urea nitrogen, creatinine, aspartate aminotransferase, glutamic pyruvic transaminase, and total bilirubin were significantly lowered after CRRT treatment (p<0.05). Perioperative management of CRRT was safe and effective for severe AMI patients.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of perioperative continuous renal replacement therapy for percutaneous coronary intervention in severe acute myocardial infarction patients

et al. 2023

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“…This Ca 2+ overload would contribute to the execution of ferroptosis in the damage. Indeed, the potential role of TRPM channels and Piezo1 in ischemia-reperfusion injury has been reported ( 122 , 123 ). For instance, Trpm2 -knockout mice showed lower lipid peroxidation in renal ischemia-reperfusion damage ( 124 ).…”

Section: Ferroptosis and Diseasementioning

confidence: 99%

Membrane Dynamics and Cation Handling in Ferroptosis

Hirata,

Mishima

2024

Physiology

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Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.

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“…Ischemia, or a reduction in blood flow, is the main cause of many serious disorders, including organ transplantation. According to animal studies, reperfusion of ischemic regions, particularly reoxygenation, adds to further tissue injury (reperfusion injury) [ 48 , 49 ]. RIRI pathogenesis has been linked to several factors, including vascular/microvascular damage, endothelial dysfunction, rapid cell necrosis, granulocyte activation, and nitric oxide (NO)/Ang II axis regulation [ 49 ].…”

Section: The Renal View Of Conventional Ras In Aki Induced By Ririmentioning

confidence: 99%

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

Karimi¹,

Maleki

Nematbakhsh

2022

J Renin Angiotensin Aldosterone Syst

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Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (AT1R)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT2 receptor (AT2R), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/AT1R and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions.

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Pathological Mechanisms Induced by TRPM2 Ion Channels Activation in Renal Ischemia-Reperfusion Injury

Cited by 9 publications

References 88 publications

Safety and efficacy of perioperative continuous renal replacement therapy for percutaneous coronary intervention in severe acute myocardial infarction patients

Safety and efficacy of perioperative continuous renal replacement therapy for percutaneous coronary intervention in severe acute myocardial infarction patients

Membrane Dynamics and Cation Handling in Ferroptosis

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

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