Pathological T2 sub‐divisions as a prognostic factor in the biochemical recurrence of prostate cancer

Caso, Jorge; Tsivian, Matvey; Mouraviev, Vladimir; Polascik, Thomas J.; Moul, Judd W.

doi:10.1111/j.1464-410x.2010.09439.x

Cited by 17 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…African-Americans (AAs) have the world's highest incidence of PCa and more than twofold higher mortality rate compared with Caucasian Americans (CAs) [1]. Overall, AA patients are younger and have higher Gleason scores, PSA levels, and incidence of palpable disease [2]. Various factors have been associated with the more aggressive prostate tumors.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship ofmiR-152and DNA methyltranferase 1

et al. 2014

View full text Add to dashboard Cite

miRNA expression in African American compared to Caucasian PCa patients has not been widely explored. Herein, we probed the miRNA expression profile of novel AA and CA derived prostate cancer cell lines. We found a unique miRNA signature associated with AA cell lines, independent of tumor status. Evaluation of the most differentially expressed miRNAs showed that miR-132, miR-367b, miR-410, and miR-152 were decreased in more aggressive cells, and this was reversed after treatment of the cells with 5-aza-2′-deoxycytidine. Sequencing of the miR-152 promoter confirmed that it was highly methylated. Ectopic expression of miR-152 resulted in decreased growth, migration, and invasion. Informatics analysis of a large patient cohort showed that decreased miR-152 expression correlated with increased metastasis and a decrease in biochemical recurrence free survival. Analysis of 39 prostate cancer tissues with matched controls (20 AA and 19 CA), showed that 50% of AA patients had statistically significant lower miR-152 expression compared to only 35% of CA patients. Ectopic expression of miR-152 in LNCaP, PC-3, and MDA-PCa-2b cells down-regulated DNA (cytosine-5)-methyltransferase 1 (DNMT1) through direct binding in the DNMT1 3'UTR. There appeared to be a reciprocal regulatory relationship of miR-152/DNMT1 expression, as cells treated with siRNA DNMT1 caused miR-152 to be re-expressed in all cell lines. In summary, these results demonstrate that epigenetic regulation of miR-152/DNMT1 may play an important role in multiple events that contribute to the aggressiveness of PCa tumors, with an emphasis on AA PCa patients.

show abstract

Section: Introductionmentioning

confidence: 99%

MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship ofmiR-152and DNA methyltranferase 1

et al. 2014

View full text Add to dashboard Cite

show abstract

“… 22 With respect to their outcomes after radical prostatectomy, recent reports have shown a favorable prognosis for T2a tumors in which more than 85% and 80% of biochemical failure-free survival rates at 10 years and 15 years, respectively. 23–25 …”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of nonpalpable prostate cancer (T1c) patients treated with radical prostatectomy

Amiya

Sasaki

Shima

et al. 2015

Prostate International

View full text Add to dashboard Cite

PurposeVarious strategies have been used to treat patients with nonpalpable prostate cancer (T1c). As one of the treatments for this stage, a radical prostatectomy was performed and the outcomes were evaluated.MethodsBetween 1993 and 2002, 117 patients with T1c received a radical prostatectomy and their follow-up were examined by the end of 2013. Patients were classified according to risk groups using prostate-specific antigen (PSA) and Gleasson score, and outcomes of respective groups were compared.ResultsApproximately 60% of patients were in low risk group, and the remaining patients were grouped into the intermediate or high risks in half. In 22% insignificant cancer was detected. Biochemical failure occurred in 14%. One patient exhibited bone metastasis, but no deaths from prostate cancer ware observed. The five and ten year overall survival rates were 92% and 75%, respectively, and the biochemical failure-free survival rates were 92% and 89%, respectively. No different outcomes were observed for the different risk groups in the overall and biochemical failure-free survival rates. T1c tumors contain a certain range of various stages of tumors, but most patients experienced favorable outcomes.ConclusionRadical prostatectomy as monotherapy is one of the treatment option for T1c prostate cancer patients, who have a long life span and belong to intermediate or high risk groups.

show abstract

“…Caso et al [10], in their study on postprostatectomy biochemical recurrence in each of the substages in pathologically confirmed T2 lesions, stated that the substages of T2 were of significance only on univariate analysis and that the most important factors were PSA and the status of the surgical margins. However, in our study, the univariate analysis differed in that only preoperative PSA and the presence of hypoechoic lesions were correlated with the prognosis of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Does the Presence of Hypoechoic Lesions on Transrectal Ultrasound Suggest a Poor Prognosis for Patients With Localized Prostate Cancer?

et al. 2013

View full text Add to dashboard Cite

PurposeThe purpose of this study was to investigate the value of hypoechoic lesions on transrectal ultrasound (TRUS) as a prognostic factor for patients with localized prostate cancer.Materials and MethodsThe patients consisted of 71 patients with pT2N0M0 disease following radical prostatectomy between 2002 and 2008. The group with hypoechoic lesions was labeled group 1, whereas the group without hypoechoic lesions was labeled group 2. The presence of hypoechoic lesions on preoperative TRUS was analyzed as a prognostic factor along with several parameters, including preoperative factors and pathologic factors. The biochemical progression-free survival (BPFS) rate was compared between the two groups according to the presence of hypoechoic lesions on TRUS.ResultsA total of 35 patients had hypoechoic lesions on TRUS, whereas 36 had no hypoechoic lesions. Preoperative baseline characteristics were not significantly different between the two groups. In the univariate analysis, BPFS showed significant differences according to the presence of hypoechoic lesions on TRUS and the preoperative prostate-specific antigen level. The BPFS rates over the first 24 months were 97.0% in group 1 and 97.1% in group 2; however, the difference in the BPFS rate over 48 months significantly widened to 75.3% compared with 91.7%, respectively. Despite this finding, no significant independent prognostic factor for BPFS was found on multivariate analysis in this patient cohort.ConclusionsThe presence of hypoechoic lesions on TRUS may suggest worse prognostic characteristics in pT2 prostate cancer. Further studies involving larger subject populations are needed to corroborate the significance of the presence of hypoechoic lesions as a prognostic factor.

show abstract

Pathological T2 sub‐divisions as a prognostic factor in the biochemical recurrence of prostate cancer

Cited by 17 publications

References 21 publications

MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship ofmiR-152and DNA methyltranferase 1

MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship ofmiR-152and DNA methyltranferase 1

Long-term outcomes of nonpalpable prostate cancer (T1c) patients treated with radical prostatectomy

Does the Presence of Hypoechoic Lesions on Transrectal Ultrasound Suggest a Poor Prognosis for Patients With Localized Prostate Cancer?

Contact Info

Product

Resources

About