Pathology and clinical behavior of thymomas.A survey of 51 cases

Legg, Merle A.; Brady, William J.

doi:10.1002/1097-0142(196509)18:9<1131::aid-cncr2820180914>3.0.co;2-f

Cited by 132 publications

(20 citation statements)

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“…The gross and histological appearance of the tumour masses in the anterior and posterior mediastinum closely resemble that of previously reported thymomas in animals and man [I, [3][4][5]8]. Several workers have proposed classifications of thymomas according to their histological appearance [3,4,7].…”

Section: Discussionsupporting

confidence: 78%

Malignant Thymoma with Metastases in a Dog

Robinson

1974

Vet Pathol

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An 8-year-old male Wire-Haired Fox Terrier with respiratory distress and cough had a malignant thymoma that had metastasised to the lungs, spleen, liver, diaphragm, bronchial and mediastinal nodes, and pericardium by transcoelomic, vascular, and lymphatic routes. Myasthenia gravis, which occurs in some human patients with thymoma, was not evident.There are few reports of true thymomas in dogs [5]. TALERMAN and GWYNN [6] described one case and in a review of the literature found only five cases. WATSON and FARROW [8] and HALL et al. [2] have since reported one case each. All the reported thymomas were benign with no evidence of metastasis.A case of a malignant thymoma in a dog in which there was infiltration of tissue with transcoelomic and embolic spread is described. Case ReportAn 8-year-old male Wire-Haired Fox Terrier had respiratory distress and cough. Rectal temperature was normal. Antibiotics were administered, but 3 days later the animal's condition had deteriorated, and percussion of the chest showed abnormal solidity on the right side. Although the left side retained resonance, rales were heard on auscultation. The dog died under anaesthesia prior to radiography. PathologyBoth pleural cavities contained a moderate quantity of watery bloodstained fluid. A pale, fairly firm nodular mass, 8 X 6 X 6 em, containing areas of haemorrhage and brown discolouration was in the anterior mediastinum, and a similar mass, 6 X 3 X 3 em, was in the posterior mediastinum ( fig. 1).at OAKLAND UNIV on June 9, 2015 vet.sagepub.com Downloaded from

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Section: Discussionsupporting

confidence: 78%

Malignant Thymoma with Metastases in a Dog

Robinson

1974

Vet Pathol

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“…Thus, type B2 and B3 tumors were supposed to have an oncologically more aggressive nature compared with type A, AB, and B1 tumors. As opposed to these findings, studies by Salyer, Eggleston 21 and Legg, Brady 31 found no association of histology with either invasion or outcome in thymoma. In the present study type AB thymoma followed by type B2, was associated with bad prognosis.…”

Section: Discussionmentioning

confidence: 72%

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

et al. 2015

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“…Other studies have suggested that completeness of resection, tumor size, and the presence of symptoms may also be important prognostic indicators [12,27,32]. Some studies suggest that histologic type (medullary versus cortical versus mixed) is an important prognostic indicator [57][58][59] whereas other studies do not [32,60,61]. Patients with autoimmune diseases such as red cell aplasia, hypogammaglobulinemia, and lupus erythematosus Johnson, Eng, Giaccone et al…”

Section: Prognosismentioning

confidence: 99%

Thymoma: Update for the New Millenium

et al. 2001

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USA. Telephone: 210-616-5648; Fax: 210-949-5085; e-mail: cthomas@saci.org www: cancerdata.com Received October 11, 2000; accepted for publication May 11, 2001. ©AlphaMed Press 1083-7159/2001 INTRODUCTIONThymic tumors are common among anterior mediastinal tumors in adults. The vast majority of thymic lesions are thymoma [1]. Thymoma is relatively unique among tumors in that the prognosis appears to be more closely related to the invasive characteristics seen at operation rather than histological appearance. Indeed, the degree of encapsulation and invasion of adjacent tissues define malignancy for these tumors rather than the histologic appearance of the tumor cells [2]. Current treatment of thymoma is often multidisciplinary in nature, and has evolved based upon a growing number of studies to date. These studies have looked at various outcomes based upon associated patient syndromes, tumor histology, and tumor staging, as well as various surgical, radiotherapeutic, chemotherapeutic, and multimodality trials. These studies form the basis of this review.

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Pathology and clinical behavior of thymomas.A survey of 51 cases

Cited by 132 publications

References 20 publications

Malignant Thymoma with Metastases in a Dog

Malignant Thymoma with Metastases in a Dog

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

Thymoma: Update for the New Millenium

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