Pathology and familial incidence of thyroiditis in a closed beagle colony

Fritz, T.E.; Zeman, R C; Zelle, M. R.

doi:10.1016/0014-4800(70)90071-7

Cited by 40 publications

(22 citation statements)

References 20 publications

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“…Lymphocytic thyroiditis in laboratory beagles does not appear to be progressive, but at one stage becomes static for many years. No clinical signs suggestive of thyroid disease were found in these beagles [5].…”

Section: Discussionmentioning

confidence: 76%

Histologic and Ultrastructural Evaluation of Thyroid Lesions Associated with Hypothyroidism in Dogs

1981

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Abstract. Thyroid lesions in 16 pet dogs with hypothyroidism were evaluated by light and electron microscopy. Lymphocytic thyroiditis, found in seven dogs, was characterized by diffuse infiltration of the thyroid gland by lymphocytes, plasma cells and macrophages with formation of some lymphoid nodules and destruction of follicles, progressing to replacement of most of the thyroid by fibrous connective tissue. The basement membrane around follicles was thick and had electron-dense deposits. The morphology of the thyroid lesions and the presence of circulating thyroglobulin autoantibodies suggested that lymphocytic thyroiditis was immune-mediated.Idiopathic follicular atrophy, found in nine dogs, was characterized by loss of thyroid parenchyma and replacement by adipose connective tissue. Degeneration of individual follicular cells was present in the early stage, with exfoliation into the colloid and interfollicular area. Most of the thyroid gland consisted of adipose connective tissue with either interspersed small follicles or individual follicular cells that had dilated rough endoplasmic reticulum, large Golgi apparatus, and intracytoplasmic microfollicles in the advanced stage. Follicular atrophy was a degenerative lesion of follicular cells of unknown cause, not associated with inflammatory destruction in the thyroid gland.Hypothyroidism in pet dogs is a metabolic disorder that can result from primary diseases of the thyroid gland or be secondary to long-standing pituitary or hypothalamic lesions that interfere with the release of thyrotropin or thyrotropin-releasing hormone. Hypothyroid dogs have a gradual decline in vigor and physical activity, and often are "heat seekers" [ 12). Varied degrees of alopecia and epidermal atrophy were reported in 48% of hypothyroid dogs [17]. Hypothyroidism in pet dogs was associated with a low level of serum triiodothyronine (38.7 k 4.1 ng/dl) and thyroxine (0.8 k 0.07 pg/dl); circulating thyroid hormone concentrations did not increase significantly after thyrotropin stimulation [7]. These changes in thyroid function were specific for hypothyroid dogs compared to dogs with other endocrinopathies or normal pet dogs. Thyroglobulin autoantibodies were found in 48% (12 of 25) pet dogs with hypothyroidism, and may be related to the cause of thyroiditis [7]. Laboratory beagles with naturally occurring lymphocytic thyroiditis also have circulating thyroid autoantibodies [ 141, but the focal thyroiditis was not associated with 299

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Section: Discussionmentioning

confidence: 76%

Histologic and Ultrastructural Evaluation of Thyroid Lesions Associated with Hypothyroidism in Dogs

1981

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“…All dogs in group V mr and V m developed high antibody titers against distemper virus and parvovirus, and all dogs in groups V mr and V r developed protective titers against rabies. 13 Changes in anti-thyroglobulin antibody activity and T 4 and TSH concentrations during the study are reported elsewhere. 11 At the time of euthanasia, the vaccine groups did not differ with regard to anti-thyroglobulin antibody activity (P 5 .64), T 4 concentration (P 5 .10), TSH concentration (P 5 .50), or thyroid weight as a percentage of the body weight (P 5 .56).…”

Section: Resultsmentioning

confidence: 99%

“…There is a breed predisposition for thyroiditis in dogs, and the genetics for susceptibility have been characterized in beagles. 4,14 In this study of 20 beagles from 5 litters, 8 of 20 (40%) had evidence of thyroiditis at postmortem examination. This percentage is higher than the incidence of 16% reported in 1 large beagle colony.…”

Section: Discussionmentioning

confidence: 99%

“…Serum T 4 and TSH concentrations in dogs were measured with chemiluminescent enzyme immunoassays previously validated for use in dogs.…”

Section: Hormone Assay Techniquesmentioning

confidence: 99%

“…1,2 Although the specific cause of canine thyroiditis is unknown, it is heritable in Beagles and Borzois. 3,4 Other breeds have an increased prevalence of this disease, suggesting that heredity plays a part in its pathogenesis. 5 Intensive vaccination protocols have been suggested as partially responsible for an increased prevalence of autoimmune diseases in dogs in recent years.…”

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confidence: 99%

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Lack of Association between Repeated Vaccination and Thyroiditis in Laboratory Beagles

Scott‐Moncrieff

Glickman

et al. 2006

Veterinary Internal Medicne

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Background: Intensive vaccination protocols have been suggested as partially responsible for an increased prevalence of autoimmune diseases in dogs in recent years. The aim of this study was to determine whether repeated routine vaccination in dogs is associated with an increased prevalence of thyroiditis.Methodology/principal findings: We conducted a prospective experimental study with 20 healthy purpose-bred Beagles. Five dogs were vaccinated with a multivalent vaccine and a rabies vaccine. Five dogs received only the multivalent vaccine, and 5 dogs received only the rabies vaccine. Five dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once a year. Blood samples were collected 1 week before euthanasia for evaluation of thyroid profiles and measurement of antibodies directed against canine thyroglobulin. Dogs were euthanized at 5.5 years of age, and the thyroid glands were evaluated histopathologically.Thyroiditis was present in 8 of 20 (40%) dogs at postmortem examination. No association was found between a dog being vaccinated and the prevalence of thyroiditis at postmortem examination. However, the power of the study to detect such an association was low because of the unexpected high prevalence of thyroiditis in the unvaccinated control dogs. Thyroid function tests were abnormal in 2 of 8 dogs with thyroiditis but were normal in all dogs without thyroiditis.Conclusions/significance: There was no evidence to support an association between routine vaccination and thyroiditis at postmortem examination in beagle dogs after repeated vaccination.

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2018

Breed Predispositions to Disease in Dogs and Cats

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Pathology and familial incidence of thyroiditis in a closed beagle colony

Cited by 40 publications

References 20 publications

Histologic and Ultrastructural Evaluation of Thyroid Lesions Associated with Hypothyroidism in Dogs

Histologic and Ultrastructural Evaluation of Thyroid Lesions Associated with Hypothyroidism in Dogs

Lack of Association between Repeated Vaccination and Thyroiditis in Laboratory Beagles

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