Pathology of gout induced by high protein diets in growing broilers

Abstract

The inestigation was carried out on the gross and histo-pathological changes that occur due to different protein diet in broilers. A total of 100, day-old broiler chicks were randomly divided into 5 groups having 20 chicks each. The chicks were fed with diets having 10 per cent (group A), 15 per cent (group B), 20 per cent (group C), 30 per cent (group D) and 40 per cent (group E) crude protein for 28 days. Post mortem examination of birds showed that relative weight of kidney was increased in birds of group E on day 28 post feeding. Grossly deposition of urate crystals in visceral organs, petechial haemorrhages and enlargement of kidney were observed. The salient histopathological changes included tophi formation, severe degenerative and necrotic changes in kidney and mild fatty changes and necrosis of hepatocytes in liver. The histopathological changes in heart, spleen and bursa of fabricius in the birds of group E on day 14 were similar to the naturally gout affected birds.

Pathology of Gout in Commercial Broiler Chicken

“…It is rather the result of kidney damage from any of a number of potential causes, which can be infectious, nutritional, toxic, poor management or possibly a combination of factors. The nutritional or metabolic causes of gout include excess of dietary calcium (Feizi et al, 2011), high protein diet (Singh and Ghosh, 2014), excess salt (Sodhi et al, 2008), low phosphorus, imbalance between Ca-P levels (Ansar et al, 2004), adulteration of feed with urea and vitamin A and D deficiency. Water deprivation followed by over dosages of certain drugs like sulphas and the antibiotic aminoglycosides (Gentamicin) often causes gout (Javed et al, 2013).…”