Pathology of Guillain-Barré Syndrome

Fatigue, pain and muscle weakness are frequent after Guillain-Barré syndrome and poliomyelitis

“…Eight patients died later, and 84 patients were contacted (55 men and 29 women). The clinical findings at the peak of acute GBS were classified according to Hughes functional grading scale [2]: 0 -healthy person; 1 -minor signs or symptoms of neuropathy but capable of manual work; 2 -able to walk without the support of a stick but incapable of manual work; 3 -able to walk with a stick, appliance or support; 4 -confined to bed or chairbound; 5 -requiring assisted ventilation; and 6 -dead. The patients included had stable health and had received no steroids or immunosuppressive treatment at least 12 months prior to participating.…”

“…The common clinical features are progressive symmetric pareses, hypo-or areflexia and sensory loss. Pain can sometimes be severe, and autonomic dysfunction is common [1,2]. There are few studies regarding longterm outcome after GBS, and the results show that the recovery is not always complete and persistent impairment may occur [3][4][5].…”

Infections and vaccinations preceding childhood Guillain-Barré syndrome: a prospective study

“…There have been several reports of vaccinations preceding GBS. Most of these are case reports or small case series in which the immunisations were linked to GBS by temporal association only, excluding alternative aetiologies or the demonstration of intrathecal antibodies [15,16]. Scientifically speaking, more appropriate case control studies have shown that vaccinations had not been more frequently performed in patients with GBS than in age-and sex-matched control populations [8,17,20,34,43].…”

“…However, most of these proposals were based on open, uncontrolled observations usually comprising a limited range of serological tests, and frequently on only anecdotal case reports [14,16,18,24]. Prospective serological testing has been performed in adults, but to the best of our knowledge it has yet to be carried out in children with GBS [20,43].…”

Guillain-Barré Syndrome: A Case Report of Post Covid-19 Vaccination in the Philippines

“…GBS is a rare but serious post-infectious immune-mediated neuropathy, and it results from the auto-immune destruction of nerves in the peripheral nervous system. The disease is rare, with the incidence rate of 0.6 to 4 per 100,000 individuals (R. A. C. Hughes, 1990). Bilateral leg weakness is the most common early motor symptom, and pain is the most common non-motor symptom (Forsberg et al, 2004).…”