Pathology reports solve "new bowel disease" riddle

The impact of fraudulent and irreproducible data to the translational research crisis – solutions and implementation

“…These very clear statements also led Lancet to finally retract the 1998 Wakefield publication in 2010 (Lancet 2010), Subsequent investigations implicated that the data were potentially fraudulent. Of the 12 children that were examined, only one had overt pathological results and the other eleven were considered normal by specialists (Deer ). In addition, the diagnosis of autism has been questioned in several of the original cases (Deer ).…”

“…These very clear statements also led Lancet to finally retract the 1998 Wakefield publication in 2010 (Lancet 2010), iv Subsequent investigations implicated that the data were potentially fraudulent. Of the 12 children that were examined, only one had overt pathological results and the other eleven were considered normal by specialists (Deer 2011b). In addition, the diagnosis of autism has been questioned in several of the original cases (Deer 2011a In summary, the Wakefield case shows fraud in research with intent to mislead about patient selection criteria, clinical histories and data, and several instances of conflicts of interest, and clear scientific, medical, professional, and ethical misconduct.…”

Affaire Wakefield : 12ans d’errance car aucun lien entre autisme et vaccination ROR n’a été montré

“…Wakefield a publié un livre sur son engagement [9]. En novembre 2011, le BMJ a interpellé les autorités du Royaume Uni suite aux révélations sur les données anatomopathologiques [10][11][12][13]. Plutôt que de paraphraser ces documents, nous avons préféré traduire les bandeaux des 3 articles du BMJ, sans reproduire les illustrations (encadré 1 disponible en complément électronique) (La rédac-trice du BMJ nous en a donné l'autorisation).…”

Institutional research misconduct

“…6 7 In an accompanying feature article, Deer explains what they add to our knowledge of the Wakefield saga. 8 The grading sheets, which we have made available on bmj.com in the public interest (web extra), present findings from the biopsies of 11 of the 12 children, scored on a scale of 0-3 for the appearance of various levels of inflammation. Each sheet has a box for indicating the presence and severity of Crohn's disease or ulcerative colitis, or for indicating other findings: "infection," "ischaemia," "non-specific," or "normal."…”