Pathophysiological and clinical aspects of malnutrition in chronic renal failure

Caimi, Gregorio; Carollo, Caterina; Presti, Rosalia Lo

doi:10.1079/nrr200599

Cited by 13 publications

(15 citation statements)

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“…Penurunan laju filtrasi glomerulus akan menurunkan asupan protein dan energi akibat meningkatnya akumulasi toksin uremikum yang menyebabkan perubahan pola makan karena [5][6][7][8] terjadinya anoreksia. Kebutuhan dan metabolisme beberapa nutrisi tubuh berubah secara signifikan, sebagai contoh adalah akibat restriksi asupan protein yang dilakukan untuk mengurangi akumulasi ureum yang berasal dari katabolisme protein.…”

Section: Pendahuluanunclassified

“…Kebutuhan dan metabolisme beberapa nutrisi tubuh berubah secara signifikan, sebagai contoh adalah akibat restriksi asupan protein yang dilakukan untuk mengurangi akumulasi ureum yang berasal dari katabolisme protein. Selain itu terjadi pula perubahan metabolisme asam amino yang dibentuk di ginjal akibat penyakit ginjal kronik itu sendiri, seperti 7,8 arginin, serin, dan tirosin. Perubahan ini menyebabkan penderita mempunyai risiko tinggi untuk terjadinya protein-calory malnutrition 5,[7][8][9] (PEM) atau malnutrisi.…”

Section: Pendahuluanunclassified

“…Malnutrisi dan inflamasi pada penderita gagal ginjal kronik predialisis digunakan sebagai prediktor luaran penderita, baik prognosis perjalanan penyakitnya, kemungkinan komplikasi yang timbul, maupun kualitas hidup penderita 3,7,8,11,19 selanjutnya.…”

Section: Pendahuluanunclassified

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Hubungan Laju Filtrasi Glomerulus Dengan Status Nutrisi Pada Penderita Penyakit Ginjal Kronik Predialisis

Pura¹,

Supriyadi²,

Nugraha³

et al. 2009

mkb

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ABSTRAKMalnutrisi banyak terjadi pada penderita penyakit ginjal kronik (PGK). Prevalensi malnutrisi pada penderita predialisis sekitar 44%. Penyebab malnutrisi pada penderita PGK predialisis bersifat multifaktorial. Hubungan laju filtrasi glomerulus (LFG) dengan status nutrisi gabungan menggunakan albumin serum, indeks massa tubuh (IMT) dan subjective global assessment (SGA) masih belum banyak diteliti. Penelitian ini bertujuan mencari hubungan LFG dengan parameter nutrisi gabungan pada subjek PGK predialisis yang berkunjung ke poliklinik ginjal hipertensi RS Hasan Sadikin Bandung dari bulan September sampai Oktober 2008. Data sekunder dan primer dikumpulkan secara konsekutif. Pemeriksaan meliputi penilaian klinis, laboratorium, dan LFG dengan metode in vivo. Analisis statistik menggunakan uji Mann-Whitney untuk melihat hubungan LFG dengan status nutrisi gabungan dengan multiple utility assessment criteria (MUAC). Tujuh puluh dua subjek terdiri dari 48 laki-laki dan 24 perempuan memenuhi kriteria penelitian. Sebanyak 79,2% subjek dengan usia di atas 50 tahun dan 54,2% dengan penyebab 2 sakit hipertensi. Rata-rata LFG 32,62 mL/mnt, albumin serum 4,10 g/dL dan IMT 23,87 kg/m . Terdapat 80,6% subjek dengan status gizi buruk dan 19,4% dengan gizi baik. Menggunakan metode MUAC, 70 subjek dengan kategori gizi baik dan 2 subjek dengan gizi buruk. Hubungan LFG terhadap parameter nutrisi ditentukan dengan uji Rank-Spearman dan hasil tidak bermakna terhadap semua variabel nutrisi (p >0,05). Hubungan LFG terhadap parameter nutrisi gabungan memberikan hasil tidak bermakna (p> 0,05). Kesimpulan: terdapat hubungan yang sangat kecil antara LFG terhadap perubahan parameter nutrisi gabungan, dengan jumlah sampel 72 subjek tidak dapat mendeteksi adanya hubungan yang bermakna.Kata kunci: PGK, LFG, albumin serum, IMT, SGA THE CORRELATION BETWEEN GLOMERULAR FILTRATION RATE (GFR) AND NUTRITIONAL STATUS INPEDIALYTIC CHRONIC KIDNEY DISEASE PATIENTS ABSTRACTProtein-energy malnutrition (PEM) is common in chronic kidney disease (CKD) patients. The prevalence of malnutrition in predialytic patients was approximately 44%. The causes of malnutrition in CKD patients are multifactorial. The correlation of glomerular filtration rate (GFR) and combined nutritional parameter such as serum albumin, body mass index (BMI) and subjective global assessment (SGA) is more need to study. The study aimed to find the correlation GFR and the combined nutritional parameter in predialytic CKD patients who attended the Nephrology-Hypertension Clinic of Hasan Sadikin Hospital between September and October 2008. The secondary and primary data were collected consecutively. The evaluation consisted of clinical assessment of nutritional status, laboratory values, and GFR by in vivo method. The combined nutritional parameter was classified into two groups using multiple utility assessment criteria (MUAC). Statistical analysis with Mann-Whitney test was used to find the correlation. Seventy two subjects (48 men and 24 women) fulfilled the criteria. The majority (79.2...

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Hubungan Laju Filtrasi Glomerulus Dengan Status Nutrisi Pada Penderita Penyakit Ginjal Kronik Predialisis

Pura¹,

Supriyadi²,

Nugraha³

et al. 2009

mkb

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“…Malnutrition of visceral proteins often occurs in many chronic illnesses such as chronic renal failure, protracted infections and cancer (10) . Clinical assessment of malnutrition is most commonly done by biochemical indicators of nutrition (11) . Serum albumin is a well-known marker of nutrition in ESRD patients.…”

Section: Introductionmentioning

confidence: 99%

Relation of Serum Albumin Level and C- reactive Protein to Hypotensive Episodes during Hemodialysis Sessions

Wahab

Hafez²,

Aziz³

2018

The Egyptian Journal of Hospital Medicine

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Background: Intradialytic hypotension (IDH) remains the most common complication of hemodialysis (HD) with potentially devastating consequences despite the technological advances regarding the hemodialysis techniques of the last decades. The increasing number of advanced-age patients, diabetics and patients with cardiovascular comorbidities undergoing hemodialysis emphasizes the need on implementation of new IDH avoidance tactics. Aim of the Work: Our work aimed to evaluate serum albumin (Alb) level and C-reactive protein level in hemodialysis patients and their correlation with dialysis-induced hypotension (DIH). Patients and Methods: This prospective study was conducted based on data collected from HD patients treated at Aswan University Hospital, dialysis unit, in a period from 1/1/2017 to 30/5/2017. It included 40 chronic HD patients with no history of endocrine tumors, diabetes mellitus, liver failure, heart failure, or unstable coronary artery disease. Patients with hemoglobin less than 9 mg/dL, feverish patients, and patients with any source of apparent infection were excluded. The age of the patients ranged from over 18 to less than 75 years. Results: : the mean value of serum albumin level in group (A) was (2.97 ± 0.71) with the highest serum albumin was 4.4 and the lowest serum albumin was 2.1, while in Group (B) the mean value of serum albumin level was (4.53 ± 0.74) with the highest serum albumin was 5.5 and the lowest serum albumin was 2.8. There was a significant decrease in serum albumin level in patients in group (A) who had developed hypotensive episodes during hemodialysis ( P value < 0.001), in group (A) also there were 18 patients had positive C-reactive protein (90 %) and 2 patients had negative C-reactive protein (10 %) with a mean value (15.67 ± 13.27), while in group B : there were 2 patients had positive C-reactive protein level (10 %) and 18 patients had negative C-reactive protein level ( 90 %) with a mean value (2.07 ± 1.48) , So, there was a significant increase in C-reactive protein level in patients in group (A) who had developed hypotensive episodes during dialysis ( P value < 0.001). Conclusion: Serum Alb. levels and high levels of CRP may predict an increased risk of DIH in regular HD patients and this was the main issue for our study, however we also found that there were some other biochemical markers, which can come inbetween with our two main markers, which confirm our results. Recommendations: Further studies on a larger scale of patients are needed to confirm these results.

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“…Caimi et al (2005) discuss the nutritional factors that affect patients in renal failure -it is a chronic inflammatory state, and there is accelerated atherosclerosis, exacerbated by malnutrition. They conclude that improved nutrition would improve the prognosis considerably.…”

mentioning

confidence: 99%

Editorial

Bender¹

2005

Nutr. Res. Rev.

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Pathophysiological and clinical aspects of malnutrition in chronic renal failure

Cited by 13 publications

References 75 publications

Hubungan Laju Filtrasi Glomerulus Dengan Status Nutrisi Pada Penderita Penyakit Ginjal Kronik Predialisis

Hubungan Laju Filtrasi Glomerulus Dengan Status Nutrisi Pada Penderita Penyakit Ginjal Kronik Predialisis

Relation of Serum Albumin Level and C- reactive Protein to Hypotensive Episodes during Hemodialysis Sessions

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