Pathophysiological role of the renin–angiotensin system on erectile dysfunction

Fraga‐Silva, Rodrigo A.; Montecucco, Fabrizio; Mach, François; Santos, Robson A.S.; Stergiopulos, Nikolaos

doi:10.1111/eci.12117

Cited by 37 publications

(36 citation statements)

References 89 publications

(205 reference statements)

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“…The renin-angiotensin system (RAS) plays an important role in the maintenance of blood pressure and tissue perfusion [16]. RAS not only functions in the cardiovascular system, including regulation of blood pressure, but also in the central nervous system [9].…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus

Zhang

Jia

et al. 2018

Cell Physiol Biochem

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Background/Aims: We aim to explore the role of angiotensin (Ang)II and the RhoA/Rho kinase signaling pathway in the pathogenesis of erectile dysfunction in diabetes mellitus (DM). Methods: Male Sprague-Dawley (SD) rats were used for experiments and short hairpin RNA (shRNA) was used to silence the AngII gene. The erectile function of rats was observed and intracavernous pressure and mean arterial pressure (ICP/MAP) were measured after electrical stimulation. Relaxation and contraction of smooth muscle in the corpus cavernosum were tested. Western blotting and quantitative RT-PCR were applied to measure the expressions of RhoA, Rho-associated kinase (ROCK)1 and ROCK2. Radioimmunoassay was applied to detect the levels of AngII. Results: Rats in the control group had the most erectile times, followed by AngII-silenced rats with DMED and rats with DMED. Rats with DMED had worse ICP and MAP than AngII-silenced rats. The contraction ability was markedly improved and relaxation ability was decreased in AngII-silenced rats with DMED as compared with rats with DMED. The levels of AngII were significantly increased in DMED rats while significantly decreased after AngII silencing. The mRNA and proteins of RhoA and ROCK2 were expressed in a similar way. Conclusion: AngII silencing improves erectile dysfunction via down-regulating the RhoA/Rho kinase signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus

Zhang

Jia

et al. 2018

Cell Physiol Biochem

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“…A national opinion study of 4017 participants aged 57-85 years found no consistent association between antihypertensive drug classes and sexual problems [149]. A pathophysiological role for the reninangiotensin system in ED involving angiotensin has been raised [150].…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Tolerability of Antihypertensive Medications in Older Adults

Dharmarajan

2015

Drugs Aging

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Several guidelines for hypertension have recently undergone revisions to incorporate an approach providing choices of medications based on age, race, and specific situations where hypertension may co-exist with disorders such as diabetes, coronary artery disease, heart failure and chronic kidney disease. Initial recommendations include diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers; beta blockers are favored in some guidelines and are a choice in specific settings. Within the classes of drugs, several antihypertensive agents provide options. This review discusses antihypertensive drugs by class, including adverse effects and tolerability, with preferences in older adults and specific settings. Adverse drug events from antihypertensive medications are discussed by class and where applicable for specific agents. Data from select studies pertinent to tolerability and adverse effects are presented in tables for several classes of drugs. The rationale for nonadherence to medication is reviewed, including the roles played by tolerability and adverse drug effects. Antihypertensive therapy in typical settings in older adults is discussed; they include hypertension in association with impaired cognition, depression, diabetes, sexual dysfunction, and falls. The key to successful therapy and tolerability is to promote a healthy lifestyle in conjunction with medications as the approach, thereby also lowering the adverse drug effects. The eventual choice of the specific drug(s) is based on risks, benefits, and patient preferences, and is best tailored for each older adult.

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“…The increase in the production of angiotensin-II as a result of elevated angiotensin-I converting enzyme (ACE) activity induces ED (Bader 2010;Fraga-Silva et al 2013;Oboh et al 2015;Akomolafe et al 2016). Therefore, the inhibition of ACE activity in turn reduces angiotensin-II levels and improves erectile function in ED patients (Dorrance et al 2002).…”

Section: Introductionmentioning

confidence: 99%