Pathophysiological Roles of Ectopic Tachygastria Induced with Antral Electrical Stimulation

Abstract

Aim: To investigate the pathophysiological roles of tachygastria using antral electrical stimulation (AES). Methods: The study was performed on 13 healthy female hound-type dogs chronically implanted with three pairs of serosal electrodes and a gastric cannula (n = 7). In the first experiment (n = 7), the antral motility was measured for three 30-min periods right after a solid meal. AES was performed during the second 30-min period at a tachygastric frequency. In the second experiment (n = 6), gastric slow waves and animal behavior were monitored in the fasting state at baseline and with various parameters of AES. Results: (1) AES at tachygastric frequencies (7–14 cpm) significantly reduced the percentage of normal 4- to 6-cpm slow waves and induced tachygastria; (2) AES significantly and substantially inhibited the antral motility in the fed state; (3) AES in the fasting state energy dependently induced symptoms, and the symptom score was linearly correlated with the stimulation frequency, and (4) there was a significant negative correlation between percentage of tachygastria and index of antral motility. Conclusions: AES induces tachygastria and inhibits the antral motility. Tachygastria is correlated with antral motility.

Gastric electrical stimulation inhibits postprandial antral tone partially via nitrergic pathway in conscious dogs

“…Retrograde GES at the tachygastrial frequency is known to induce gastric dysrhythmia and inhibit antral motility (5). Induction of gastric dysrhythmia with retrograde GES was reported to inhibit postprandial antral motility; conceivably, it should also reduce antral tone (46).…”

Systematic review: applications and future of gastric electrical stimulation

“…40,41 Because of its pacing capability, GES with long pulses is also able to induce tachygastria when delivered at a tachygastrial frequency (a frequency higher than the physiological frequency). 42,43 GES-induced tachygastria was reported to be associated with antral hypomotility, mediated via the adrenergic pathway. 43 …”

Cutaneous gastric electrical stimulation alters gastric motility in dogs: New option for gastric electrical stimulation?

“…The other set of parameters was the same as set 1 except for an increase in stimulation frequency to 10 c.p.m., which was called tachygastrial frequency. It has been reported that GES at the tachygastrial frequency using internal serosal electrodes induces tachygastria or tachyarrhythmia 16 …”

“…The bag was non‐compliant, 700 mL in maximal capacity and attached to the distal end of a double‐lumen catheter. The catheter was connected to a computer‐controlled electrical barostat device (Distender Series IIR; G & J Electronics, Willowdale, Ontario, Canada) 16 . The bag was briefly inflated with 300 mL air to fully unfold and deflated completely thereafter.…”

“…The catheter was connected to a computer-controlled electrical barostat device (Distender Series IIR; G & J Electronics, Willowdale, Ontario, Canada). 16 The bag was briefly inflated with 300 mL air to fully unfold and deflated completely thereafter. After a brief rest period, the minimal distending pressure was determined by inflating the bag in 1-mmHg increments until a pressure at which evident respiratory excursions were recorded and the bag volumes were equal to or larger than 30 mL.…”