Pathophysiology and natural history of atrial septal defect

Gloan, Laurianne Le; Legendre, Antoine; Iserin, Laurence; Ladouceur, Magalie

doi:10.21037/jtd.2018.02.80

Cited by 61 publications

(59 citation statements)

References 65 publications

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“…This might be related to the findings of the higher incidence of the defect with severe or large size ASD in the studied cases and presentation of clinical symptoms at earlier ages. It was documented that, a small ASDs are commonly associated with a fairly small shunt and with a minimum magnitude of blood flow through the defect and often produces no apparent symptoms, because the heart and the lungs may not have to work harder than the usual [2,40,49,50]. Whereas large ASDs are haemodynamically significant and allow up to 2 to 3 times the ordinary amount of blood to circulate through the right chambers of the heart and the lungs.…”

Section: Discussionmentioning

confidence: 99%

Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Musa

Afework

Bedru

et al. 2020

Preprint

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BackgroundAlthough it appears that an atrial septal defect (ASD) occurs frequently in Ethiopia there are only a few published studies available so far on this matter. This study is therefore aimed to evaluate the prevalence and echocardiographic characteristics of ASDs in children (aged ≤ 15 years) attended a cardiac referral center in Ethiopia.MethodsThis retrospective study reviewed the sociodemographic data and the initial echocardiographic findings of the children with ASDs who were diagnosed at the Cardiac Center of Ethiopia (CCE), Addis Ababa, from January 2016 to December 2018.ResultsA total of 116 children (56.9% females and 43.1% males) with a mean age of 3.47± 3.72 years (range: 15 days to 15 years) were diagnosed with ASDs. The most prevalent age groups were infancy (50%) and early childhood (29.3%). All the studied cases were diagnosed with ostium secundum ASD while there were no cases with ostium primum, sinus venosus and coronary sinus defects. The most frequent ostium secundum ASD was large size (61.2%) and was more frequent in infants (23.3%) and young children (21.6% of all cases).ConclusionOstium secundum ASD is the most prevalent IAS defect and more common among female cases. Large size ostium secundum ASD is more frequent in the studied children and is more prevalent in infants and young children. This survey may provide data for the currently lacking statistics on ASDs at the CCE and might be helpful for the management and follow-up of children with ASDs. Scheduled follow-up and intervention studies are required to evaluate the incidence and patterns of spontaneous and surgical closure of ASD and their outcomes.

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Section: Discussionmentioning

confidence: 99%

Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Musa

Afework

Bedru

et al. 2020

Preprint

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“…Es sabido que en una CIA grande se igualan las presiones entre ambas aurículas, y la distensibilidad de ambos ventrículos determinará el grado de hiperflujo. La HTP puede desarrollarse en respuesta a una sobrecarga crónica de la circulación pulmonar causada por una CIA de izquierda a derecha, con la consiguiente sobrecarga de volumen, aumento del gasto cardíaco derecho y una sobrecarga de la presiones pulmonares, lo que llevaría a un remodelado vascular pulmonar (1,2) . Pueden encontrarse diferentes valores de PSAP a pesar de similares sobrecargas de volumen.…”

Section: Discussionunclassified

Un caso de CIA compleja: ¿dónde están los bordes del septum interauricular?

Amor

Rousse

Veloso

et al. 2020

Rev Ecocar Pract (RETIC)

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La comunicación interauricular (CIA) ostium secundum es la cardiopatía congénita más frecuente en la edad adulta. Se presenta el caso de un varón de 45 años, asintomático, con gran sobrecarga de cavidades derechas al que se detecta una CIA de gran tamaño. Debido a su gran tamaño y la ausencia de bordes suficientes, es dificultosa la clasificación del tipo de defecto, revisando el diagnóstico diferencial con el tipo seno venoso inferior. Se discuten también las dificultades de valoración no invasiva de la presión pulmonar ante un reflujo tricúspide de escasa magnitud y pobre representación espectral.

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“…Due to the high blood flow from left to right, ASDs can cause changes in the heart : enlargement of right cardiac chambers, right ventricular remodeling and failure, tricuspid regurgitation, myocardial cell hypertrophy and fibrosis, and cellular injury. These changes can predispose to lethal arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

A Case of Sudden Death Due to Persistent Severe Pulmonary Arterial Hypertension After Late Atrial Septal Defect Closure

Serinelli

Gitto

Stoppacher

2019

Journal of Forensic Sciences

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Atrial septal defects (ASDs) are one of the most prevalent congenital cardiac anomalies in adults. These interatrial communications can produce changes in the right heart (remodeling and failure) and the lungs (pulmonary hypertension). Most adults with ASDs are surgically treated with excellent results. However, a small fraction of patients is at risk for postoperative complications, particularly the persistence of pulmonary hypertension. A case of a 47‐year‐old woman who was found unresponsive in the bathroom of her house and died despite resuscitative efforts is described. According to medical records, the woman underwent a surgical repair of an atrial septal defect at the age of 37. At the autopsy, macroscopic and microscopic signs of advanced pulmonary hypertension were detected, highlighting the importance for the forensic pathologists to recognize pulmonary hypertension as a cause of sudden death in adults with a history of late surgical closure of an atrial septal defect.

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Pathophysiology and natural history of atrial septal defect

Cited by 61 publications

References 65 publications

Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Un caso de CIA compleja: ¿dónde están los bordes del septum interauricular?

A Case of Sudden Death Due to Persistent Severe Pulmonary Arterial Hypertension After Late Atrial Septal Defect Closure

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