Pathophysiology and Treatment of Pruritus in Elderly

Chung, Bo Young; Um, Ji Young; Kim, Jin Cheol; Kang, Seok Young; Park, Chun Wook; Kim, Hye One

doi:10.3390/ijms22010174

Cited by 38 publications

(47 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…53 Aplikasi pembersih non-iritatif, penggunaan pelembap yang mengandung humektan atau bersifat oklusif, serta menghindari bahan yang dapat mencetuskan gatal merupakan strategi yang paling efektif untuk menjaga integritas sawar kulit dan mencegah terjadinya pruritus. 11,53,56 Golongan AH1 generasi pertama bersifat lipofilik sehingga dapat melewati sawar darah otak dan menimbulkan efek sedasi dan antikolinergik kuat. 55,56 Oleh sebab itu, golongan obat tersebut tidak direkomendasikan pada geriatri.…”

Section: Fototerapi (Loe 1-2)unclassified

See 1 more Smart Citation

Perkembangan Terapi Sistemik pada Pruritus

Andardewi¹,

Budianti²,

Legiawati³

et al. 2022

J. Kdokt Meditek

View full text Add to dashboard Cite

Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi tersebut disebabkan oleh berbagai hal, misalnya penyakit kulit, penyakit sistemik, atau idiopatik, gangguan psikiatri, serta penyakit neurologis. Pruritus menjadi masalah kesehatan karena dapat memberi dampak negatif terhadap kualitas hidup pasien. Pendekatan tata laksana pruritus diberikan secara bertingkat mulai dari terapi dasar, terapi target, dan terapi simtomatik. Pada kasus pruritus kronik yang refrakter maupun pruritus tanpa sebab yang diketahui, terapi simtomatik berperan besar dan dapat diberikan pada pasien tersebut. Tata laksana pada pruritus kronik saat ini banyak diteliti seiring dengan ditemukan berbagai mekanisme yang mendasari terjadinya pruritus. Sesuai dengan patofisiologi dari pruritus, terapi sistemik yang dikembangkan menargetkan pada reseptor spesifik di sistem saraf dan sistem imunitas yang berperan pada jalur sinyal pruritus. Berbagai terapi terbaru yang masih diteliti dalam uji klinis menunjukkan hasil yang menjanjikan dan berpotensi menjadi pilihan terapi pada pasien dengan pruritus kronik.

show abstract

Section: Fototerapi (Loe 1-2)unclassified

“…11,53,56 Golongan AH1 generasi pertama bersifat lipofilik sehingga dapat melewati sawar darah otak dan menimbulkan efek sedasi dan antikolinergik kuat. 55,56 Oleh sebab itu, golongan obat tersebut tidak direkomendasikan pada geriatri. Golongan AH1 generasi kedua lebih dipilih karena efek samping yang lebih minimal.…”

Section: Fototerapi (Loe 1-2)unclassified

Perkembangan Terapi Sistemik pada Pruritus

Andardewi¹,

Budianti²,

Legiawati³

et al. 2022

J. Kdokt Meditek

View full text Add to dashboard Cite

show abstract

“…Infant emollients should be free of fragrances, dyes, and preservatives, which are known to pose irritation and allergy risks. Emollients are generally non-antipruritic, but they lubricate and moisturize the skin, protect the integrity of the stratum corneum and skin barrier, and treat dry skin [ 68 ]. Emollients may be used as monotherapy for eczema in children or in combination with topical corticosteroids or calcineurin inhibitors.…”

Section: Treatments Of Itch In Children and Adolescencementioning

confidence: 99%

“…Side effects of cyclosporine are hypertension, infection, increased BUN/creatinine, or nephrotoxicity. Azathioprine can cause nausea, vomiting, anemia, and hypersensitivity: reactions include dizziness, diarrhea, fatigue, and skin rashes [ 68 ]. Mycophenolate mofetil has an immunosuppressive effect by specifically blocking lymphocyte proliferation and antibody production.…”

Section: Treatments Of Itch In Children and Adolescencementioning

confidence: 99%

Differential Diagnosis and Treatment of Itching in Children and Adolescents

Kang

Chung

et al. 2021

Biomedicines

Self Cite

View full text Add to dashboard Cite

Itching is prevalent in children with skin disorders and associated with effects on their mood, quality of life, and social functioning. Surprisingly, there are no data on childhood prevalence of pruritus in the general population. The aim of this article is to explore the epidemiology, clinical manifestation, and treatment for itch (pruritus) in the pediatric population (from infancy to adolescence), and to be helpful to primary care physicians who assess and diagnose pediatric patients with itching. In this study, we searched for specific keywords using PubMed and MEDLINE (Ovid) and, then, refined the retrieved searches for each cause and treatment. As a result of reviewing the literature, atopic dermatitis was shown to be the most common cause of itching, especially during infancy and through preschool. Not only skin disorders but also systemic diseases, drugs, and postburn states can predispose an individual to itching in childhood. There are traditional and newly developed treatment modalities for itching in pediatric patients. However, because the pharmacokinetics and pharmacodynamics of childhood are different from those of adults, the medications for itching have to be applied carefully for these age groups. There are many areas to be elucidated regarding the prevalence and objective assessment of pruritus in pediatric patients. Moreover, the safety profiles of medications in the pediatric population need to be better understood. Further studies to investigate itching in childhood are warranted.

show abstract

“…In a rosacea-like mouse model, the clinical features of rosacea were seen to improve after injection of a YAP/TAZ inhibitor. The pathophysiology and treatment of pruritis in elderly skin has been discussed [14]. There are many factors that may contribute to itch in elderly skin, but one of these may be decreased lamellar granule secretion and reduced intercellular lipids in the stratum corneum.…”

mentioning

confidence: 99%