Pathophysiology of Achalasia

Lo, Wai–Kit; Mashimo, Hiroshi

doi:10.1007/978-3-319-13569-4_2

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Heredity also has a role in this disorder. While the secondary achalasia is caused by infections, intraluminar tumors such as cardidia tumors, extraluminal pressure from pancreatic pseudocysts, anticholinergic drugs, or postoperative vagotomy (1).…”

Section: Introductionmentioning

confidence: 99%

Acute respiratory failure in achalasia with megaesophagus

Aditya Pradana Kartinofan,

Bowo Adiyanto,

Hermin Prihartini

2023

GSC Adv. Res. Rev.

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Introduction: Achalasia is one of the most common causes of dysphagia. Typical symptoms include difficulty in swallowing, regurgitation, weight loss, and chest pain. Megaesophagus is a complication of advanced achalasia. This condition rarely causes tracheal compression with acute dyspnea. Case Presentation : A 51 years old man came to the emergency room and had complaints of intermittent shortness of breath accompanied by a cough for 1 week, chest pain that came and went, nausea (+), vomiting (+), difficulty in swallowing food, and fever (-). The medical history showed that the patient went to gastroenterology polyclinic to examine his dysphagia and esophageal sphincter dilatation 2 months ago. The patient received treatment in the ward, but the complaints he suffered was getting worse, so he was transferred to the ICU with a diagnosis of acute respiratory failure. Conclusion: The patient was then intubated and decompressed for the megaoesophagus he suffered with the aim to reduce the compression of the trachea and lungs by the esophagus. The patient was getting better and could be extubated on the 3rd day of treatment.

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Section: Introductionmentioning

confidence: 99%

Acute respiratory failure in achalasia with megaesophagus

Aditya Pradana Kartinofan,

Bowo Adiyanto,

Hermin Prihartini

2023

GSC Adv. Res. Rev.

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Determining long-term outcome of transthoracic Heller's myotomy when other methods fail: A single centere cases series

Baram

Essa

2019

International Journal of Surgery Open

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Objective: We aimed to estimate the long-term outcomes of transthoracic Heller's myotomy without fundoplication. Methods: This single centere, retrospective study included patients followed up for signs of cure, recurrence of symptoms, and different aspects of quality of life estimated over several years. Data were obtained directly from the patients and the medical records. The scores of patients with early and late dysphagia were compared preoperatively and postoperatively to estimate the quality of life (QoL). Results: A total of 48 patients (37 women and 11 men) who underwent surgery for achalasia between 2008 and 2018 were included. The mean age was 43.5 (19–68) years. The mean follow-up duration was 60.5 (1–120) months. Dysphagia, regurgitation, and heartburn were the most common symptoms, occurring in 100% of patients. The outcomes were an excellent success rate and estimation of QoL. After the first 6 months of follow-up, patients who underwent surgery developed grades 1–3 dysphagia. After 1–10 years of follow-up, 39 (81.25%) patients had grade 1 dysphagia, whereas 9 (18.75%) still had grade 2 dysphagia. During the long-term follow-up, only 77% of patients developed regurgitation, while 91.6% had heartburn. QoL changed according to dysphagia scores (from 5 to 1). However, the score of 26 patients (54.16%) decreased to 1; after 1 year of follow-up, 42 patients (87.5%) obtained a dysphagia score of 1. After 1–10 years of follow-up, 97.2% of patients underwent barium oesophagogram and showed a small-calibre oesophagus. Conclusion: Transthoracic Heller's myotomy is a safe and durable procedure that is associated with a durable long-term success rate and less recurrence, without necessity for any type of anti-reflux surgery. Highlights:

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Pathophysiology of Achalasia

Cited by 2 publications

References 34 publications

Acute respiratory failure in achalasia with megaesophagus

Acute respiratory failure in achalasia with megaesophagus

Determining long-term outcome of transthoracic Heller's myotomy when other methods fail: A single centere cases series

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