Pathophysiology of Angiogenesis and Its Role in Vascular Disease

Wong, Nathan K.P.; Solly, Emma L; Bursill, Christina A.; Tan, Joanne; Ng, M.

doi:10.1007/978-3-030-43683-4_5

Cited by 3 publications

(3 citation statements)

References 97 publications

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“…Hypoxia and inflammatory conditions induce the release of angiogenic and inflammatory agents, which stimulate spontaneous angiogenesis [33]. Studies have indicated that the neovessels primarily originate from a pre-existing vasa vasorum, which constitutes a microvasculature network responsible for supplying arterial walls [34,35]. Neovessels are commonly found in the fibrous cap as well as in the medial and lateral corners of plaques, but their presence at the base is infrequent [36].…”

Section: Vulnerable Plaquesmentioning

confidence: 99%

Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability—Narrative Review

Kopyto,

Czeczelewski,

Mikos

et al. 2023

JCM

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The risk assessment for carotid atherosclerotic lesions involves not only determining the degree of stenosis but also plaque morphology and its composition. Recently, carotid contrast-enhanced ultrasound (CEUS) has gained importance for evaluating vulnerable plaques. This review explores CEUS’s utility in detecting carotid plaque surface irregularities and ulcerations as well as intraplaque neovascularization and its alignment with histology. Initial indications suggest that CEUS might have the potential to anticipate cerebrovascular incidents. Nevertheless, there is a need for extensive, multicenter prospective studies that explore the relationships between CEUS observations and patient clinical outcomes in cases of carotid atherosclerotic disease.

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Section: Vulnerable Plaquesmentioning

confidence: 99%

Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability—Narrative Review

Kopyto,

Czeczelewski,

Mikos

et al. 2023

JCM

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“…Angiogenesis is a fundamental process during embryogenesis and under physiological and pathological conditions in adults. It is an endogenous mechanism to create new blood vessels from a pre-existing vascular network, which is distinct from vasculogenesis by which the blood vessels are formed de novo [ 1 ]. In adults, angiogenesis is tightly regulated by hypoxia, flow stress, and an array of pro- or anti-angiogenic factors to control normal physiological growth, reproduction, wound repair, and response to ischemia.…”

Section: Introductionmentioning

confidence: 99%

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Gandhi,

Wang,

et al. 2024

Cell Biosci

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Background Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive. Results and summary To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.

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“…7 The process of angiogenesis, which forms new blood vessels from the pre-existing vascular network, especially capillaries, is essential to normal postnatal growth and development. 8 Angiogenesis is a wellcoordinated process consisting of a series of successive steps. 9 This pathway includes several enzymes and regulatory components.…”

Section: Introductionmentioning

confidence: 99%

Gaseous Ozone-Treated Human Dental Pulp Stem Cells Secretome Enhances Angiogenesis in a Chick Embryo Model

Pawar,

Mishra,

Channe

et al. 2024

JBSMFS

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Background: Ozone has become more common in medicine across the globe as an adjuvant treatment method for a variety of illnesses. The combination of ozone and treated human dental pulp stem cell-conditioned media hDPSCs-CM can enhance angiogenesis due to their synergistic action, resulting in increased growth factor expression. Objectives: The aim of the study was to evaluate the angiogenic potential of ozone-treated human dental pulp stem cell-conditioned media (hDPSCs-CM). Materials and Method: HDPSCs were isolated from the extracted tooth. Passaged four cells were characterized with flow cytometry and then exposed to 10μg/mL gaseous Ozone concertation. The conditioned media (CM) were obtained from the treated cells, and growth factor analysis was performed. The functionality of the Ozonated hDPSCs-CM was assessed by the Chick Yolk Sac Membrane (YSM) assay. Results: Ozonated hDPSCs-CM had significantly higher (p<0.01) expression of angiopoietin-2 (Ang-2), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), macrophage colony stimulating factor (M-CSF), and vascular endothelial growth factor (VEGF). The in-ovo YSM assay revealed a notably greater pro-angiogenic potential associated with Ozonated hDPSC-CM

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Pathophysiology of Angiogenesis and Its Role in Vascular Disease

Cited by 3 publications

References 97 publications

Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability—Narrative Review

Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability—Narrative Review

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Gaseous Ozone-Treated Human Dental Pulp Stem Cells Secretome Enhances Angiogenesis in a Chick Embryo Model

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