Pathophysiology of burn shock and burn edema

Kramer, George C.; Lund, T.; Beckum, Orlando K.

doi:10.1016/b978-1-4160-3274-8.50011-8

Cited by 37 publications

(47 citation statements)

References 103 publications

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“…Since then, it has been thought to have an important role in the pathophysiology of burns, particularly in the early phase of edema after a burn [1]. We know now that concentrations of histamine in blood are in the range of 100 times greater than those in plasma, and are related to the number of basophils.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive thermal injuries result in a massive inflammatory response that has both local and systemic effects which, if not alleviated, may lead to shock [1][2]. Histamine is one of the classic mediators of inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Histamine is thought to be an important mediator of vascular dysfunction in burn wounds, particularly in the early phase [1,6]. Previous data have relied mostly on animal studies [5,7], and we know of few consistent newer data in humans [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Urinary excretion of histamine and methylhistamine after burns

Johansson

Bäckryd

Granérus

et al. 2012

Burns

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary excretion of histamine and methylhistamine after burns

Johansson

Bäckryd

Granérus

et al. 2012

Burns

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“…The exact mechanisms underlying these findings have, however not been fully elucidated. Earlier investigations and textbooks have proposed histamine, serotonin, and oxygen radicals as possible mediators of this effect in the systemic circulation [1][2], but to our knowledge there are no studies of burns in humans that have set out to investigate the genesis of these early reactions after a burn in which the pulmonary changes have been measured with thermodilution.…”

Section: Introductionmentioning

confidence: 99%

Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2

Johansson

Steinvall

Herwald

et al. 2015

Journal of Burn Care & Research

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Leucocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data supports that an important target for such extravasation is the lungs and that leucocytes when they adhere to endothelial cells cause an increase in vascular permeability. We investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic change in concentration of blood leucocytes after a burn. This is a prospective, exploratory, single-centre study. We measured the dynamic changes of leucocytes in blood starting early after the burn, pulmonary vascular permeability index (PVPI) by thermodilution, and PaO2:FiO2-ratios in 20 patients during the first 21 days after a major burn (>20% total burn surface area %).Median total burn surface area was 40% (IQR 25-52) and full thickness burn 28% (IQR 2-39). There was a correlation between the early (<24 hours) alteration in white blood cell count and both early increased pulmonary vascular permeability (r=0.63, p=0.004) and the decreased oxygenation index defined as PaO2:FiO2<27kPa (p=0.004).We have documented a correlation between dynamic change of blood leucocytes and pulmonary failure early after burns.

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“…Independent of patient's age consequence of SPOI formation is the following: encephalopathy → gastrointestinal dysfunction → acute injury of the lungs → cardiovascular dysfunction → DBC → Hepatic dysfunction → renal dysfunction [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Burn Shock and Multiple Organ Failure Syndromes

Hakimov¹

2013

SJCM

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Medicine. Vol. 2, No. 3, 2013, pp. 87-91. doi: 10.11648/j.sjcm.20130203.15 Abstract: Critical condition, developing in patients with burns during the burn shock more often produce the development of nonspecific reactions in the body, manifested as the system or the organ insufficiency and are determined by the term «syndrome of poly organ insufficiency» (SPOI). The course and treatment of 189 patients with burn shock have been analyzed. With the purpose of investigation all patients with burn shock were subdivided into 2 groups: The first (control) group included 79 patients (23 children, 56 adults) and was treated according to traditional antishock infusion-transfusion therapy without inotropic therapy. The second (basic) group included 110 patients (33 children, 77 adults) with burn shock and underwent a complex, antishock infusion-transfusion therapy with employment of inotropic and organoprotective therapy depending on dysfunction of vitals and systems. All patients with burn shock underwent general clinical examinations of: cardiovascular and respiratory systems, functions of the lever, kidneys and gastrointestinal tract for revealing of polyorgan insufficiency (POI). The victims of burns -material prove high spread POI in patients with burns, that requires complex, purposeful conservative (local and general) and surgical treatment for its reduction and prevention of unfavorable results.

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Pathophysiology of burn shock and burn edema

Cited by 37 publications

References 103 publications

Urinary excretion of histamine and methylhistamine after burns

Urinary excretion of histamine and methylhistamine after burns

Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2

Burn Shock and Multiple Organ Failure Syndromes

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