Pathophysiology of Cirrhosis and Portal Hypertension

SummaryBackgroundChronic use of proton pump inhibitors (PPIs) in patients with impaired liver function may worsen cytochrome P450 (CYP450) activity, predisposing them to clinically relevant drug–drug interactions. The 13C‐aminopyrine breath test (13C‐ABT) is a non‐invasive tool to study CYP450‐dependent liver function.AimsTo assess 13C‐ABT modifications with different PPIs in patients with cirrhosisMethodsSixty consecutive patients with HCV‐related cirrhosis and indication to start PPI therapy were randomised to receive omeprazole 20 mg/day, esomeprazole 20 mg/day, lansoprazole 15 mg/day, pantoprazole 40 mg/day or rabeprazole 20 mg/day. 13C‐ABT was performed at baseline and on the 15th day of PPI therapy.ResultsAt baseline, mean values of max 13C% dose/h and 13C% cum dose at 120 minutes did not differ significantly among groups. On the 15th day of therapy, max 13C% dose/h and 13C% cum dose at 120 minutes did not significantly differ with respect to baseline for pantoprazole (P = 0.184 and P = 0.309, respectively) or rabeprazole (P = 0.536 and P = 0.286, respectively), but were significantly decreased on omeprazole (P = 0.013 and P = 0.015, respectively), esomeprazole (P = 0.009 and P = 0.001, respectively), and lansoprazole (P = 0.033 and P = 0.035, respectively).ConclusionsIn patients with cirrhosis, omeprazole, esomeprazole and lansoprazole inhibit microsomal activity while pantoprazole and rabeprazole do not have a significant impact. Should our data be confirmed in larger cohort studies, pantoprazole and rabeprazole could be safely recommended for patients with cirrhosis.

show abstract

Impact of proton pump inhibitors on cytochrome P450 activity assessed by ¹³C‐aminopyrine breath test in patients with cirrhosis

Rocco

Compare

Sgamato

et al. 2020

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Pathophysiology of Cirrhosis and Portal Hypertension

Cited by 1 publication

References 99 publications

Impact of proton pump inhibitors on cytochrome P450 activity assessed by ¹³C‐aminopyrine breath test in patients with cirrhosis

Impact of proton pump inhibitors on cytochrome P450 activity assessed by ¹³C‐aminopyrine breath test in patients with cirrhosis

Contact Info

Product

Resources

About

Pathophysiology of Cirrhosis and Portal Hypertension

Cited by 1 publication

References 99 publications

Impact of proton pump inhibitors on cytochrome P450 activity assessed by 13C‐aminopyrine breath test in patients with cirrhosis

Impact of proton pump inhibitors on cytochrome P450 activity assessed by 13C‐aminopyrine breath test in patients with cirrhosis

Contact Info

Product

Resources

About

Impact of proton pump inhibitors on cytochrome P450 activity assessed by ¹³C‐aminopyrine breath test in patients with cirrhosis

Impact of proton pump inhibitors on cytochrome P450 activity assessed by ¹³C‐aminopyrine breath test in patients with cirrhosis