Pathophysiology of Obesity and Diabetes

Tufail, Tabussam; Ijaz, Aiman; Noreen, Sana; Arshad, Muhammad Umair; Gilani, Syed Amir; Bashir, Shahid; Din, Ahmad; Shahid, Muhammad Zia; Khan, Ammar Ahmad; Khalil, Anees Ahmed; Awuchi, Chinaza Godswill

doi:10.1007/978-3-030-72999-8_2

Cited by 7 publications

(2 citation statements)

References 57 publications

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“…Dyslipidemia is prevalent among patients with coexisting risk factors of cardiovascular diseases, including diabetes, diabetes, hypertension, human immunodeficiency virus, etc. (Gebreegziabiher et al, 2021;Tufail et al, 2021;Yasmin et al, 2021). It is associated with over 50% of cases of ischemic heart disease worldwide, and over 4 million deaths per year (Gebreegziabiher et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Aja

Chiadikaobi

Agu

et al. 2023

Food Science & Nutrition

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This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant (p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly (p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma (p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.

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Section: Introductionmentioning

confidence: 99%

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Aja

Chiadikaobi

Agu

et al. 2023

Food Science & Nutrition

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“…Obesity is characterized by an extra amount of adipose tissue at a degree that influences the physiological, psychological, and physical health and well-being of an individual [8]. Obesity is associated with an increased risk of many other diseases and disorders, including cardiovascular diseases, kidney diseases, diabetes, certain cancers, inflammatory diseases, infertility, immune system dysfunction, and infections [8][9][10]. Besides, there is an association between obesity, severity, and mortality in patients with infectious diseases [11] such as COVID- 19.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, and Practices regarding Obesity among Population of Urban (Douala) and Rural (Manjo) Areas in Cameroon

Dongmo,

Asongni,

Mba

et al. 2023

International Journal of Chronic Diseases

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Knowledge, attitude, and practice (KAP) studies have recently been suggested as a useful tool to understand the specificity of the population related to a disease. However, in Cameroon, there is a lack of information based on KAP studies regarding obesity. This study has been designed to collect basic indicators on the KAP of the populations regarding overweight and obesity in urban and rural areas in Cameroon (Douala and Manjo). For this purpose, an epidemiological community-based cross-sectional descriptive study was conducted in these two areas using a well-structured questionnaire. Sociodemographic and medical characteristics and KAP information were assessed. For the quantification of KAP, a score varying from 0 (poor knowledge, attitude, or practices) to 100 (good knowledge, attitude, or practices) was attributed for each question. Correlations between knowledge, attitude, and practice were determined using inferential statistics tests which were χ 2 test, independent Student t -test, ANOVA (followed by Tukey’s post hoc test), and Pearson correlation coefficient. Results reveal that living in a rural area (Manjo), being overweight or obese, having complete secondary education, and being married increase the knowledge and the practice score. There is a strong and positive correlation between knowledge and practice score. However, there is no association between attitude and practice and between attitude and knowledge. Reducing the disparities between knowledge, attitude, and practices constitutes a serious track in a holistic strategy for the management of obesity in these areas.

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Whey Protein from Milk as a Source of Nutraceuticals

Awuchi

2022

Food and Agricultural Byproducts as Important Source of Valuable Nutraceuticals

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Pathophysiology of Obesity and Diabetes

Cited by 7 publications

References 57 publications

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Knowledge, Attitude, and Practices regarding Obesity among Population of Urban (Douala) and Rural (Manjo) Areas in Cameroon

Whey Protein from Milk as a Source of Nutraceuticals

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