Pathophysiology of stress cardiomyopathy: A comprehensive literature review

Houri, Hasan Nabil Al; Jomaa, Sami; Jabra, Massa; Alhouri, Ahmad Nabil; Latifa, Yosef

doi:10.1016/j.amsu.2022.104671

Cited by 14 publications

(17 citation statements)

References 52 publications

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“…CRP is a powerful predictor and risk factor for myocardial injury (68). A key factor in SC progression is the overactivation of the sympathetic nervous system so high levels of CA can effectively reflect the degree of sympathetic nerve activation (69,70).…”

Section: Discussionmentioning

confidence: 99%

Establishment and effect evaluation of a stress cardiomyopathy mouse model induced by different doses of isoprenaline

Zhu

et al. 2023

Exp Ther Med

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The optimum dose of isoprenaline (ISO) required to induce stress cardiomyopathy (SC) in mice is not known. The present study aimed to investigate the dose-response association and determine the optimum dose of ISO to establish a high-morbidity/low-mortality SC mouse model to simulate the clinical symptoms of SC. A total of 72 6-week-old wild-type female mice (C57BL/6) were randomly divided into control mice administered normal saline and mice treated with increasing ISO concentrations (5, 10, 25, 50 and 100 mg/kg ISO intraperitoneal injections daily for 14 consecutive days). All mice were analysed by body weight assessment, open field test (OFT), echocardiography (Echo), electrocardiogram (ECG), assessment of myocardial pathology and quantification of cortisol, brain natriuretic peptide (BNP), cardiac troponin T (cTnT), catecholamine (CA) and C-reactive protein (CRP). Compared with the control group, the 25 and 50 mg/kg ISO groups exhibited the most prominent weight changes and lower mortality. The open-field test showed a significant decrease in autonomous activity behaviour in the 25 and 50 mg/kg ISO groups compared with the control group (P<0.05). Echo revealed that the apex of the heart was balloon-like in the 25 and 50 mg/kg ISO groups, along with prominent left ventricular dyskinesia. ECG showed a significant increase in ST segment amplitude, QT interval and Q amplitude (P<0.05) in the 25 and 50 mg/kg ISO group compared with the control group. Haematoxylin and eosin staining of heart tissue showed a disordered arrangement of myocardial cells, dissolution of myocardial fibres and cytoplasm, notable widening of myocardial cell space, oedema and hyperaemia of the interstitium, whereas heart tissue of the control group was structurally intact. Compared with the control group, the 25 and 50 mg/kg ISO groups exhibited significantly higher levels of cortisol, BNP, cTNT, CA and CRP (P<0.05). A high-incidence low-mortality SC model was successfully and stably developed by administration of 25 and 50 mg/kg ISO. Such models may provide a basis for the development of other animal models of SC.

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Section: Discussionmentioning

confidence: 99%

Establishment and effect evaluation of a stress cardiomyopathy mouse model induced by different doses of isoprenaline

Zhu

et al. 2023

Exp Ther Med

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“…It might contribute to cardiovascular risk and morbidity. The excessive activation of the sympathetic nervous system and subsequent high levels of catecholamines could initiate the process [27,28]. When these illnesses occur, employees are absent from work or are not fully functioning in the workplace due to unhealthy conditions.…”

Section: Resultsmentioning

confidence: 99%

The Relationship between Occupational Stress and Diet Quality with Productivity Loss in Islamic School Teachers in Medan: A Cross-sectional Study

et al. 2022

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Occupational stress and poor dietary practices have become a global health concern. Workers with poor dietary practices may be less productive and present at work. This study examined the relationship between occupational stress and diet quality on productivity loss among Islamic school teachers in Medan. This cross-sectional study was conducted on 50 Islamic school teachers in Medan. They were aged 19-64 years old and recruited using purposive sampling. Their occupational stress and diet quality were evaluated using the perceived stress scale (PSS) and the balanced diet index (BDI). Productivity loss was assessed based on the number of primary working days missed (absenteeism) due to poor health during six months. Negative binomial regression was used to examine the association between occupational stress and diet quality with productivity loss. The mean occupational stress, diet quality, and absenteeism were 44.89, 34.87, and 0.86 days, respectively. After controlling sociodemographic characteristics, the regression model indicated that productivity loss was positively associated with occupational stress (p=0.006). Consuming a high-quality diet was negatively associated with productivity loss (p=0.010). It concluded that occupational stress and diet quality were associated with teachers’ productivity loss. The study highlights the importance of occupational health promotion policies for teachers.

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“…The name is descriptive of the echocardiogram appearance of the left ventricle at the end of the systolic phase that appears like the Japanese octopus trap (tako for octopus, tsubo for pot) [ 1 , 2 ]. In a systematic review, the diagnosis of stress cardiomyopathy was up to 2% of the cases suspected with acute coronary syndrome or ST-elevation myocardial infarction [ 2 ]. There are few published case reports of Takotsubo cardiomyopathy during pregnancy [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Various proposed mechanisms include excessive catecholamines, coronary artery spasms, and microvascular dysfunction. It was found to be associated more with psychiatric and neurological disorders [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Takotsubo Syndrome (Broken-Heart Syndrome or Stress Cardiomyopathy) in an Epileptic Pregnant Woman: A Case Report

Harb¹,

Abdelkareem²,

Hazari³

et al. 2023

Cureus

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Stress cardiomyopathy (Takotsubo syndrome) is a rare and transient cardiac dysfunction that has been reported in pregnant women with multiple triggering conditions. In general, those cases recovered from the acute cardiac insult within a few weeks.We report a 33-year-old 22 weeks pregnant woman, who presented with an episode of status epilepticus and subsequently developed acute heart failure. She had full recovery within three weeks and continued her pregnancy till term. She became pregnant again two years after this initial insult, remained asymptomatic with stable cardiac function and had normal vaginal delivery at term.

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Pathophysiology of stress cardiomyopathy: A comprehensive literature review

Cited by 14 publications

References 52 publications

Establishment and effect evaluation of a stress cardiomyopathy mouse model induced by different doses of isoprenaline

Establishment and effect evaluation of a stress cardiomyopathy mouse model induced by different doses of isoprenaline

The Relationship between Occupational Stress and Diet Quality with Productivity Loss in Islamic School Teachers in Medan: A Cross-sectional Study

Takotsubo Syndrome (Broken-Heart Syndrome or Stress Cardiomyopathy) in an Epileptic Pregnant Woman: A Case Report

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