Pathway and Regulation of Lysine Biosynthesis in<i>Brevibacterium lactofermentum</i>

Tosaka, Osamu; Takinami, Kôichi

doi:10.1080/00021369.1978.10862930

Cited by 15 publications

(13 citation statements)

References 3 publications

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“…The occurrence of the DAP pathway (found in Enterobacteriaceae) in C. glutamicum is supported by the facts that in this bacterium DAP decarboxylase 15 ,16) [EC 4.1.1.20] and dihydrodipicolinate synthase 17 ) [EC 4.2.1.52] have been characterized, and that meso-DAP decarboxylase deficient mutants accumulated both meso-and L,Lisomers of DAP. 15 ,16) This is also supported by the evidence that N-acetyl-e-keto-ex-aminopimelate synthetase occurs in B.lactofermentum 18 ) which is closely related to C. glutamicum.…”

supporting

confidence: 70%

Involvement of meso-α,∊-Diamino-pimelateD-Dehydrogenase in Lysine Biosynthesis inCorynebacterium glutamicum

Ishino

Yamaguchi

Shirahata

et al. 1984

Agricultural and Biological Chemistry

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supporting

confidence: 70%

Involvement of meso-α,∊-Diamino-pimelateD-Dehydrogenase in Lysine Biosynthesis inCorynebacterium glutamicum

Ishino

Yamaguchi

Shirahata

et al. 1984

Agricultural and Biological Chemistry

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“…biosynthesis of lysine and alanine. 6 ) This result suggests that the metabolism of precursors contributes significantly to the production of Llysine. The present report describes the effect of alanine productivity on the accumulation of L-Iysine in Brev.…”

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confidence: 94%

Production of L-Lysine by Alanine Auxotrophs Derived from AEC Resistant Mutant of Brevibacterium lactofermentum

Tosaka

Hirakawa

Yoshihara

et al. 1978

Agricultural and Biological Chemistry

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“…15,[19][20][21] The methods for deriving of mutants with low CS or PD reported previously are as follows: reversion of glutamate auxotrophs with a CS defect,21) derivation of fJ-fiuoropyruvate-sensitive mutants,20) and reversion of acetate auxotrophs with a PD defect. IS) Compared with these methods, the method developed in this study seems to be simpler and more practical.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Properties ofα-Ketobutyrate-resistant Lysine-producing Mutants fromBrevibacterium flavum

Shiio¹,

Sugimoto²,

Kawamura³

1993

Bioscience, Biotechnology, and Biochemistry

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The growth of Brevihacterium flavum F Al-30, a L-Iysine-producing mutant strain with an aspartokinase desensitized to feedback inhibition, was almost completely inhibited by a:-ketobutyrate (a:KB) at concentrations more than 4 mg/ml. Aspartic acid hydroxamate (Asphx) did not inhibit the growth at a concentration up to 6 mg/ml, but slightly stimulated the a:KB inhibition. Mutants resistant to a:KB in the presence and absence of Asphx (type-I and -II, respectively) were derived and further selceted by their lysine productivity. The best producers among the type-I and -II mutants produced 41.9 and 29.4 g/liter of L-Iysine·HCI, 1.9-and 1.4-fold that by the parent, respectively. The type-II mutant was confirmed to be resistant to a:KB alone, but was still sensitive to a:KB in the presence of Asphx, similar to the parent. The type-I mutants were resistant to a:KB in the presence and absence of Asphx. Pyruvate dehydrogenase (PD) activity or both PD and citrate synthase (C8) activities significantly decreased in the type-II or -I mutants, respectively. The apparent Km of PD with respect to pyruvate and that of C8 with respect to oxaloacetate

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Pathway and Regulation of Lysine Biosynthesis inBrevibacterium lactofermentum

Cited by 15 publications

References 3 publications

Involvement of meso-α,∊-Diamino-pimelateD-Dehydrogenase in Lysine Biosynthesis inCorynebacterium glutamicum

Involvement of meso-α,∊-Diamino-pimelateD-Dehydrogenase in Lysine Biosynthesis inCorynebacterium glutamicum

Production of L-Lysine by Alanine Auxotrophs Derived from AEC Resistant Mutant of Brevibacterium lactofermentum

Isolation and Properties ofα-Ketobutyrate-resistant Lysine-producing Mutants fromBrevibacterium flavum

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