Pathways mediating CRF-induced inhibition of gastric emptying in rats

Coşkun, Tamer; Bozkurt, Ayhan; Ali̇can, İnci̇; Özkutlu, Uǧur; Kurtel, Hızır; Yeğen, Berrak Ç.

doi:10.1016/s0167-0115(96)02066-6

Cited by 42 publications

(24 citation statements)

References 29 publications

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“…CRF decreases food intake (Krahn et al 1986;Schwartz et al 1995), inhibits gastric functioning (Coskun et al 1997), and disrupts reproductive behavior and physiology (Sirinathsinghji 1986).…”

Section: Introductionmentioning

confidence: 99%

“…While having no effects on its own, central pretreatment with a specific CRF-receptor antagonist, α-h-CRF 9-41 , blocks subsequent stress-induced anorexia (Krahn et al 1986), sleep disruptions (Gonzalez and Valatx 1997), cardiovascular function (Morimoto et al 1993), gastric emptying (Coskun et al 1997), and immunological efficiency (Panerai et al 1997). A CRF1-receptor antagonist reverses states of stress-induced depression (Mansbach et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

et al. 1998

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Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of drinking therefore subsequently increases. CRF also decrease food intake, and might decrease ethanol drinking similarly. We addressed these hypotheses directly by assessing the effects of intracerebroventricular (i.c.v.) CRF upon ethanol drinking (1 h/day). Rats were provided drinking tubes containing ethanol solutions that were gradually incremented in concentration (from 2% to 8% w/v, over 38 days). Ethanol intakes remained stable, ranging from 0.4 to 0.5 g/kg per hour on average, and a two-bottle choice test revealed that ethanol was preferred reliably to water. Third-i.c.v. cannulae were surgically implanted and CRF or vehicle was acutely injected immediately prior to the sessions. CRF dose-dependently reduced ethanol intake by 31% (0.5 microg) and 64% (5.0 microg), and reduced 24-h food by 9% and 21%, respectively, but did not alter body weights. I.c.v. CRF reduced ethanol drinking despite any acute stress-like effects that may have been present. Hence, these data are inconsistent with the tension reduction hypothesis. On the other hand, our results support the concept that food intake and ethanol drinking may be mediated by similar mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

et al. 1998

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“…Among two CRF receptor subtypes, CRF type 1 receptor is highly involved in anxiety-related behavior and CRF type 2 receptor is involved in regulating food intake and peripheral functions such as gastric acid secretion or gastric emptying. CRF is a relatively selective ligand for CRF type 1 receptor, whereas urocortin is a ligand more selective for CRF type 2 receptor [25,26] . The density of c-Fos-positive cells in the paraventricular nucleus (PVN) was significantly increased by ip injection of des-acyl ghrelin compared to vehicle-injected controls [7] ( Figure 4B).…”

Section: Crf Type2mentioning

confidence: 99%

Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats

Fujimiya

Asakawa²,

Ataka³

et al. 2008

WJG

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“…1 It is known that both humans and experimental animals undergo changes in gastrointestinal motor and secretory functions when subjected to stress. 2 The major mechanism in this process is the breakdown of splanchnic microcirculation, which results in ischemia of the stomach mucosa, with the release of pepsin and hydrochloric acid (HCl) into the lumen. The stress-related gastric ulcer is a serious complication of exposure to extreme stress.…”

Section: Introductionmentioning

confidence: 99%

Omeprazole is More Effective than Famotidine for Preventing Acute Gastritis in Rats

Topaloğlu¹,

Müftüoğlu

Aktürk

et al. 2004

Surg Today

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Pathways mediating CRF-induced inhibition of gastric emptying in rats

Cited by 42 publications

References 29 publications

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats

Omeprazole is More Effective than Famotidine for Preventing Acute Gastritis in Rats

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