2016
DOI: 10.1186/s12864-016-3352-4
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Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence

Abstract: BackgroundIn culturing normal diploid cells, senescence may either happen naturally, in the form of replicative senescence, or it may be a consequence of external challenges such as oxidative stress. Here we present a comparative analysis aimed at reconstruction of molecular cascades specific for replicative (RS) and stressinduced senescence (SIPS) in human fibroblasts.ResultsAn involvement of caspase-3/keratin-18 pathway and serine/threonine kinase Aurora A/ MDM2 pathway was shared between RS and SIPS. Moreov… Show more

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Cited by 24 publications
(24 citation statements)
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“…8 Senescent cells are alive but display typical features of an enlarged, flattened morphology, senescence-associated heterochromatin marks, accumulation of lipofuscin granules, expression of β-galactosidase and lack of mitogenic responses. 9 An important characteristic of senescent cells is their production of a series of proteins named as the senescence-associated secretory phenotype (SASP). 9 An important characteristic of senescent cells is their production of a series of proteins named as the senescence-associated secretory phenotype (SASP).…”
Section: G Ener Al Con Cep T Of Cellul Ar S Ene Scen Ce and S Ene Smentioning
confidence: 99%
See 2 more Smart Citations
“…8 Senescent cells are alive but display typical features of an enlarged, flattened morphology, senescence-associated heterochromatin marks, accumulation of lipofuscin granules, expression of β-galactosidase and lack of mitogenic responses. 9 An important characteristic of senescent cells is their production of a series of proteins named as the senescence-associated secretory phenotype (SASP). 9 An important characteristic of senescent cells is their production of a series of proteins named as the senescence-associated secretory phenotype (SASP).…”
Section: G Ener Al Con Cep T Of Cellul Ar S Ene Scen Ce and S Ene Smentioning
confidence: 99%
“…1 Cellular senescence can be classified into two different types according to the presence or the absence of telomere shortening: replicative senescence caused by shortening of telomeres and premature senescence caused by other stress signals such as aberrant oncogene activation and genomic damage. 9 An important characteristic of senescent cells is their production of a series of proteins named as the senescence-associated secretory phenotype (SASP). 10 Through the SASP, senescent cells can affect surrounding cells by secreting various inflammatory cytokines, chemokines, growth factors and extracellular matrix remodelling factors such as interleukin 1α (IL-1α), interleukin 6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), TGF-β, connective tissue growth factor (CTGF) and monocyte chemoattractant protein-1 (MCP-1).…”
Section: G Ener Al Con Cep T Of Cellul Ar S Ene Scen Ce and S Ene Smentioning
confidence: 99%
See 1 more Smart Citation
“…Currently, two major types of cellular senescence are considered: replicative senescence and stress-induced premature senescence (SIPS). In general, these types of senescence are distinguished by the number of divisions at which the senescence occurs [32].…”
Section: Mechanismsmentioning
confidence: 99%
“…The work by Kural et al [6] considers molecular genomics models of aging. In culturing normal diploid cells, senescence may either happen naturally, in the form of replicative senescence, or it may be a consequence of external challenges such as oxidative stress.…”
mentioning
confidence: 99%