Abstract. Increasing evidence suggests that commercial airline pilots can experience physical, mental, and social health difficulties. Qualitative interviews with commercial airline pilots explored the relationship between work-related stress and well-being. Participatory workshops involving pilots were conducted. The methodology of this action-based research involved a blend of person-centered design approaches; specifically, “stakeholder evaluation” and “participatory design.” The findings further support the hypothesis that pilot well-being is being negatively affected by the nature of their work. The biopsychosocial model of the lived experience of a pilot, as presented in this paper, provides a useful structure to examine pilot well-being, and to identify and scope potential coping strategies to self-manage health and well-being issues associated with the job of being a pilot.