Patient and treatment factors associated with survival among adult glioblastoma patients: A USA population-based study from 2000–2010

Pan, I‐Wen; Ferguson, Sherise D.; Lam, Sandi

doi:10.1016/j.jocn.2015.03.032

Cited by 69 publications

(56 citation statements)

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“…We propose several explanations for these findings. First, while numerous studies report a protective effect of marriage on cancer mortality , other studies find marriage associated with lower survival (which is consistent with our findings). Alternatively, the relationship may vary depending on the history of a person's marital status: for example, in a meta‐analysis of the association of social networks with cancer mortality , survival was lowest for individuals who were never married compared to individuals who were divorced, separated or widowed.…”

Section: Caregiver Status and Patient Survivalsupporting

confidence: 92%

Associations between advanced cancer patients' survival and family caregiver presence and burden

et al. 2016

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We conducted a randomized controlled trial (RCT) of an early palliative care intervention (ENABLE: Educate, Nurture, Advise, Before Life Ends) for persons with advanced cancer and their family caregivers. Not all patient participants had a caregiver coparticipant; hence, we explored whether there were relationships between patient survival, having an enrolled caregiver, and caregiver outcomes prior to death. One hundred and twenty‐three patient‐caregiver dyads and 84 patients without a caregiver coparticipant participated in the ENABLE early versus delayed (12 weeks later) RCT. We collected caregiver quality‐of‐life (QOL), depression, and burden (objective, stress, and demand) measures every 6 weeks for 24 weeks and every 3 months thereafter until the patient's death or study completion. We conducted survival analyses using log‐rank and Cox proportional hazards models. Patients with a caregiver coparticipant had significantly shorter survival (Wald = 4.31, HR = 1.52, CI: 1.02–2.25, P = 0.04). After including caregiver status, marital status (married/unmarried), their interaction, and relevant covariates, caregiver status (Wald = 6.25, HR = 2.62, CI: 1.23–5.59, P = 0.01), being married (Wald = 8.79, HR = 2.92, CI: 1.44–5.91, P = 0.003), and their interaction (Wald = 5.18, HR = 0.35, CI: 0.14–0.87, P = 0.02) were significant predictors of lower patient survival. Lower survival in patients with a caregiver was significantly related to higher caregiver demand burden (Wald = 4.87, CI: 1.01–1.20, P = 0.03) but not caregiver QOL, depression, and objective and stress burden. Advanced cancer patients with caregivers enrolled in a clinical trial had lower survival than patients without caregivers; however, this mortality risk was mostly attributable to higher survival by unmarried patients without caregivers. Higher caregiver demand burden was also associated with decreased patient survival.

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Section: Caregiver Status and Patient Survivalsupporting

confidence: 92%

Associations between advanced cancer patients' survival and family caregiver presence and burden

et al. 2016

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“…Studies like (Koul, Dubey, Torri, Kakumanu, & Goyal, 2012;Pan, Ferguson, & Lam, 2015) had similar findings, stating that GTR has a better survival rate than does partial resection or biopsy. Brain overlap GBM and GCG tumors are associated with higher mortality rates than are supratentorial and infratentorial tumors (p < .001).…”

Section: Discussionmentioning

confidence: 80%

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Abdulrahman

Bukhari

et al. 2019

Brain and Behavior

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Objectives The current study aims to find the differences between glioblastoma multiforme (GBM) and giant cell glioblastoma (GCG) regarding mortality and prognosis among adults and elderly patients in the U.S. Methods and Materials This study is a historical cohort type of study and is conducted on adults and elderly individuals with GBM or GCG from the years 1985–2014 in the U.S. Data were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The study exposure was GBM or GCG and the outcome was mortality. The potential confounders were age, sex, race, ethnicity, year of diagnosis, primary site, brain overlap, and surgery. A chi‐square test was used for categorical data. A univariate analysis was used for variables having a p‐value <.05. Potential confounders were selected and evaluated using multivariate logistic regression models to calculate the odds ratio with stepwise selection. Results The study sample was 25,117. The incidences of GBM and GCG were not similar in relation to age group. Also, Spanish–Hispanic ethnicity was independently protective of GBM and GCG as compared to Non‐Spanish–Hispanic ethnicity patients with GBM have a higher mortality rate than do GCG patients. The mortality rate was higher among patients diagnosed before 2010. Conclusion GCG was not statistically significant in association to reduced mortality. Non‐Spanish–Hispanics with GBM or GCG had a higher mortality rate than did Spanish–Hispanics. Factors such as being female, being age 59–65, and having a year of diagnosis before 2010 were independently associated with increased mortality.

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“…To the best of our knowledge, the reason for this finding remains unknown. It is interesting to note that male sex also was postulated as an independent risk factor for survival in a large US population‐based study …”

Section: Discussionmentioning

confidence: 99%

Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009

Gramatzki

Dehler

Rushing

et al. 2016

Cancer

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BACKGROUND A population‐based analysis of patients with glioma diagnosed between 1980 and 1994 in the Canton of Zurich in Switzerland confirmed the overall poor prognosis of glioblastoma. To explore changes in outcome, registry data were reevaluated for patients diagnosed between 2005 and 2009. METHODS Patients with glioblastoma who were diagnosed between 2005 and 2009 were identified by the Zurich and Zug Cancer Registry. The prognostic significance of epidemiological and clinical data, isocitrate dehydrogenase 1 (IDH1)R132H mutation status, and O6 methylguanine DNA methyltransferase (MGMT) promoter methylation status was analyzed using the Kaplan‐Meier method and the Cox proportional hazards model. RESULTS A total of 264 patients with glioblastoma were identified, for an annual incidence of 3.9 compared with the previous incidence of 3.7. The mean age of the patients at the time of diagnosis was 59.5 years in the current cohort compared with 61.3 years previously. The overall survival (OS) rate was 46.4% at 1 year, 22.5% at 2 years, and 14.4% at 3 years in the current study compared with 17.7% at 1 year, 3.3% at 2 years, and 1.2% at 3 years as reported previously. The median OS for all patients with glioblastoma was 11.5 months compared with 4.9 months in the former patient population. The median OS was 1.9 months for best supportive care, 6.2 months for radiotherapy alone, 6.7 months for temozolomide alone, and 17.0 months for radiotherapy plus temozolomide. Multivariate analysis revealed age, Karnofsky performance score, extent of tumor resection, first‐line treatment, year of diagnosis, and MGMT promoter methylation status were associated with survival in patients with IDH1R132H‐nonmutant glioblastoma. CONCLUSIONS The OS of patients newly diagnosed with glioblastoma in the Canton of Zurich in Switzerland markedly improved from 1980 through 1994 to 2005 through 2009. Cancer 2016;122:2206–15. © 2016 American Cancer Society.

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Patient and treatment factors associated with survival among adult glioblastoma patients: A USA population-based study from 2000–2010

Cited by 69 publications

References 50 publications

Associations between advanced cancer patients' survival and family caregiver presence and burden

Associations between advanced cancer patients' survival and family caregiver presence and burden

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009

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