Patient-centered healthcare

Mendoza, Oscar

doi:10.1038/7157

Nat Biotechnol

1999

DOI: 10.1038/7157

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Patient-centered healthcare

Oscar Mendoza¹

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“…Like the shift of telephone booth centered telecommunication to ubiquitous wireless communication from last few decades, healthcare is starting a paradigm shift from hospital centered care to ubiquitous care 1 2 . Emerging technologies are enabling new terms such as telemedicine, e-hospital, e-health and u-health 1 2 3 4 5 . One of the key features of ubiquitous healthcare is wireless pervasive monitoring 1 6 .…”

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confidence: 99%

A zero power harmonic transponder sensor for ubiquitous wireless μL liquid-volume monitoring

Huang

Chen

Hung

et al. 2016

Sci Rep

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Autonomous liquid-volume monitoring is crucial in ubiquitous healthcare. However, conventional approach is based on either human visual observation or expensive detectors, which are costly for future pervasive monitoring. Here we introduce a novel approach based on passive harmonic transponder antenna sensor and frequency hopping spread spectrum (FHSS) pattern analysis, to provide a very low cost wireless μL-resolution liquid-volume monitoring without battery or digital circuits. In our conceptual demonstration, the harmonic transponder comprises of a passive nonlinear frequency multiplier connected to a metamaterial-inspired 3-D antenna designed to be highly sensitive to the liquid-volume within a confined region. The transponder first receives some FHSS signal from an interrogator, then converts such signal to its harmonic band and re-radiates through the antenna sensor. The harmonic signal is picked up by a sniffer receiver and decoded through pattern analysis of the high dimensional FHSS signal strength data. A robust, zero power, absolute accuracy wireless liquid-volume monitoring is realized in the presence of strong direct coupling, background scatters, distance variance as well as near-field human-body interference. The concepts of passive harmonic transponder sensor, metamaterial-inspired antenna sensor, and FHSS pattern analysis based sensor decoding may help establishing cost-effective, energy-efficient and intelligent wireless pervasive healthcare monitoring platforms.

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confidence: 99%

A zero power harmonic transponder sensor for ubiquitous wireless μL liquid-volume monitoring

Huang

Chen

Hung

et al. 2016

Sci Rep

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The long-term value of genomics companies

Bains

2000

J. Chem. Technol. Biotechnol.

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This paper analyses the business model on which genomics companies base their future value as a result of performing discovery programmes in collaboration with partner companies who then develop products from the knowledge generated. A model of the deal-¯ow and consequent cash requirements and generation of a company delivering discovery genomics or pharmacogenomics resources and technology in presented. It is demonstrates that on a net present value (NPV) basis, investing in target discovery using genomics is not as attractive as public valuations of the companies would suggest, and rarely provides Internal Rates of Return (IRR, the discount rate at which NPV is zero) greater than the NASDAQ composite average. A realistic model of a company performing only genomics target discovery has an IRR of around 12%; this is below the majority of established manufacturing company stocks. The business model is independent of technology details: exactly the same economics apply to proteomics, transcriptomics and other investment-intensive discovery technologies. It is concluded that venture capital (VC) investment in genomics will be driven by the likelihood of a rapid exit rather than the genuine underlying value of the company, and that private investors looking to build long-term value will increasingly look to other technologies as the problems of discovery technology companies become more apparent.

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Personalized genomic information: preparing for the future of genetic medicine

et al. 2010

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The falling cost of sequencing means that we are rapidly approaching an era in which access to personalized genomic information is likely to be widespread. Here, four experts with different insights into the field of genomic medicine answer questions about the prospects for using this type of information. Their responses highlight the diverse range of issues that must be addressed - ranging from scientific to ethical and logistical - to ensure that the potential benefits of personal genomic information outweigh the costs to both individuals and societies.

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Patient-centered healthcare

Cited by 3 publications

References 0 publications

A zero power harmonic transponder sensor for ubiquitous wireless μL liquid-volume monitoring

A zero power harmonic transponder sensor for ubiquitous wireless μL liquid-volume monitoring

The long-term value of genomics companies

Personalized genomic information: preparing for the future of genetic medicine

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