Patient-Centered Outcomes in the Management of Anemia: A Scoping Review

Staibano, Phillip; Perelman, Iris; Lombardi, Julia; Davis, Alexandra; Tinmouth, Alan; Carrier, Marc; Stevenson, Ciara; Saidenberg, Elianna

doi:10.1016/j.tmrv.2018.07.001

Cited by 11 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prospective studies, addressing the limitations identified from our work, are already underway . A recent scoping review found evidence of poor reporting of patient‐centred outcomes in anaemia management studies , although data are beginning to emerge on the effects of anaemia management on quality of life .…”

Section: Discussionmentioning

confidence: 99%

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

et al. 2020

View full text Add to dashboard Cite

Summary Pre‐operative anaemia is associated with poor outcomes after elective surgery but its relationship with outcomes after emergency surgery is unclear. We analysed National Emergency Laparotomy Audit data from 1 December 2013 to 30 November 2017, excluding laparotomy for haemorrhage. Anaemia was classified as ‘mild’ 129–110 g.l−1; ‘moderate’ 109–80 g.l−1; or ‘severe’ ≤ 79 g.l−1. The primary outcome was 90‐day mortality. Secondary outcomes were 30‐day mortality, return to theatre and postoperative hospital stay. The primary outcome was available for 86,763 patients, of whom 45,306 (52%) were anaemic. There were 12,667 (15%) deaths at 90 postoperative days and 9246 (11%) deaths at 30 postoperative days. Anaemia was associated with increased 90‐day and 30‐day mortality, odds ratio (95%CI): mild, 1.15 (1.09–1.21); moderate, 1.44 (1.36–1.52); and severe, 1.42 (1.24–1.63), p < 0.001 for all; mild, 1.07 (1.00–1.12), p = 0.030; moderate, 1.30 (1.21–1.38), p < 0.001; and severe, 1.22 (1.05–1.43), p = 0.010, respectively. All categories of anaemia were associated with prolonged hospital stay, adjusted coefficient (95%CI): mild, 1.31 (1.01–1.62); moderate, 3.41 (3.04–3.77); severe, 2.80 (1.83–3.77), p < 0.001 for all. Moderate and severe anaemia were associated with increased risk of return to the operating theatre, odds ratio (95%CI): moderate 1.13 (1.06–1.21), p < 0.001; and severe 1.23 (1.06–1.43), p = 0.006. Pre‐operative anaemia is common in patients undergoing emergency laparotomy and is associated with increased postoperative mortality and morbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This response correlates with the anticipated time for IV iron uptake and synthesis within the body (37). Other studies have found a similar improvement in patient reported fatigue after an intravenous iron infusion (26,38,39,40,41). Darlington et al (2008) found that exercise capacity and symptoms improved after an iron infusion in patients with congestive cardiac failure (CCF) and iron de ciency, and that this effect was more pronounced if the patient was also anaemic (37).…”

Section: Discussionmentioning

confidence: 69%

“…The PRO tools that are used must have a high content validity, which is de ned as the extent to which an instrument measures the important aspect of concepts that developers or users purport it to assess (20). (26). FACT/FACIT-fatigue was originally developed to measure cancer-associated fatigue but has since been shown to assess fatigue and related symptoms on daily activities in various chronic conditions.…”

Section: The Ideal Pro Instrumentsmentioning

confidence: 99%

The Use of Patient Reported Outcome Measures and Experiences in Patients With Anaemia Receiving Intravenous Ferric Carboxymaltose: A Cohort Study 

Wyssusek

Town

Norton

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Fatigue due to iron deficiency anaemia (IDA) has not been regularly evaluated in clinical studies. The aim of this study is to assess patient reported outcomes amongst individuals diagnosed with IDA before and after receiving intravenous ferric carboxymaltose. Fatigue and satisfaction will be measured using the validated Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-fatigue) scale and the validated Nordic Patient Experiences Questionnaire (NORPEQ), respectively.Methods: Thirty eligible patients receiving IV ferric carboxymaltose at the Royal Brisbane and Women’s Hospital were enrolled to participate in interviews; two patients were lost to follow up. Mean change in FACIT-fatigue score from the baseline day of IV ferric carboxymaltose treatment to week 4 post treatment was measured. Patient satisfaction with the overall process of treatment was measured on the day of treatments. Approval for Ethics exemption was obtained by the RBWH ethics committee.Results: A one-way ANOVA was conducted to compare the patient questionnaire results at baseline on the day of receiving the IV ferric carboxymaltose and after a four week follow up via telephone interview. There was a significant effect of improvement of FACIT-fatigue scores on follow up at the p<.05 level [F(1,54), = 7.60, p = .008]. Patient satisfaction was assessed by analysing NORPEQ, an 8-item questionnaire. Patients had reported overall higher satisfaction scores at baseline and follow-up, averaging 91% and 94%, respectively and were not significant in treatment at the p<.05 level [F(1,52), = 1.37, p = .246].Conclusions: The use of validated patient reported outcome measures and experiences provides valuable insights into the patients’ perspective. Physiological and biochemical data outcomes are often used as the gold-standard of medical research. However, patient experience and self-perceived physiological improvement are imperative when measuring the success of a medical intervention and the benefits it provides to patients and consumers. Further research is needed to combine the subjective patient experience data with objective physical, biochemical, or physiological data. Combined, they can provide a thorough and comprehensive assessment of an intervention. Furthermore, a comparison of outcomes administering IV iron or oral iron therapy would provide valuable information about efficacy.Trial registration: Not registered

show abstract

“…While these are important, disease outcomes of interest to researchers, clinicians, and administrators may not reflect what is most important to patients. Patient‐centered outcomes measure the impact of disease and treatment on physical, social, and mental well‐being . Patient‐centered outcomes have not been commonly reported in transfusion trials, nor have many studies been conducted in the outpatient transfusion setting .…”

mentioning

confidence: 99%

“…Patient‐centered outcomes measure the impact of disease and treatment on physical, social, and mental well‐being . Patient‐centered outcomes have not been commonly reported in transfusion trials, nor have many studies been conducted in the outpatient transfusion setting . In this issue of TRANSFUSION , the Red Cells in Outpatients Transfusion Outcomes study, from the National Heart, Lung, and Blood Institute REDS‐III program, begins to address this gap in the literature.…”

mentioning

confidence: 99%

Outpatient transfusions: time to study what matters to patients

Lin

Buckstein

2019

Transfusion

View full text Add to dashboard Cite

show abstract

Patient-Centered Outcomes in the Management of Anemia: A Scoping Review

Cited by 11 publications

References 19 publications

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

The Use of Patient Reported Outcome Measures and Experiences in Patients With Anaemia Receiving Intravenous Ferric Carboxymaltose: A Cohort Study

Outpatient transfusions: time to study what matters to patients

Contact Info

Product

Resources

About

Patient-Centered Outcomes in the Management of Anemia: A Scoping Review

Cited by 11 publications

References 19 publications

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

The association of pre‐operative anaemia with morbidity and mortality after emergency laparotomy

The Use of Patient Reported Outcome Measures and Experiences in Patients With Anaemia Receiving Intravenous Ferric Carboxymaltose: A Cohort Study&nbsp;

Outpatient transfusions: time to study what matters to patients

Contact Info

Product

Resources

About

The Use of Patient Reported Outcome Measures and Experiences in Patients With Anaemia Receiving Intravenous Ferric Carboxymaltose: A Cohort Study