Patient‐centered prioritization of bladder cancer research

Smith, Angela; Chisolm, Stephanie; Deal, Allison M.; Spangler, Alejandra; Quale, Diane Zipursky; Bangs, Rick; Jones, Josette; Gore, John L.

doi:10.1002/cncr.31530

Cited by 45 publications

(34 citation statements)

References 7 publications

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“…For example, the EORTC risk calculator forms the basis of the European Association of Urology NMIBC guidelines, and the CUETO calculator predicts risks after BCG treatment 10 . However, uptake of these tools has been disappointingly low, and studies incorporating the perspectives of urologists and patients with NMIBC suggest there is a need to enhance the existing tools to broaden applicability and usability 6,7 . The EORTC and CUETO risk calculators are based on pooled data sets of patients from European clinical trials and may not accurately reflect non‐European patients or real‐world settings.…”

Section: Discussionmentioning

confidence: 99%

“…Both patients and urologists have called for research into detailed prediction tools for NMIBC recurrence and progression. In surveys of patients from the Bladder Cancer Advocacy Network, research questions pertaining to decision‐making tools and determining the appropriate time frame for radical cystectomy in high‐risk NMIBC were most important to patients with bladder cancer 6 . In a recent qualitative study of urologists by our group, participants endorsed a need for more evidence to improve communication about recurrence and progression risk 7 .…”

Section: Introductionmentioning

confidence: 95%

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Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle‐invasive bladder cancer in a multisite, community‐based cohort

Garg

McMullen

Leo

et al. 2020

Cancer

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Background Nonmuscle‐invasive bladder cancer (NMIBC) has heterogeneous recurrence and progression outcomes. Available risk calculators estimate recurrence and progression but do not predict the recurrence stage or grade, which may influence downstream treatment. The objective of this study was to predict risk‐stratified NMIBC recurrence and progression based on recurrence tumor classification and grade. Methods In total, 2956 patients with NMIBC (

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle‐invasive bladder cancer in a multisite, community‐based cohort

Garg

McMullen

Leo

et al. 2020

Cancer

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“…To some extent, cellular targeting by CQs can be achieved by conjugation with specific moieties, including sugar groups, and by the generation of hybrid molecules, such as CQ-artemisinin. [297][298][299] Grant calls that cover the topic of drug repurposing technology to reprogram immune responses with cell-selectivity and parallel onco-suppression will be beneficial to both basic and translational research. Even though CQ is an established drug against certain conditions, its use in cancer is still in its infancy, as is evident by the clinical trials that have been publicized.…”

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

“…Research priorities, however, can change in the public sector. [297][298][299] Grant calls that cover the topic of drug repurposing technology to reprogram immune responses with cell-selectivity and parallel onco-suppression will be beneficial to both basic and translational research.…”

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

2019

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Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.

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“…A recent stakeholder-driven research prioritization study involving bladder cancer patients and caregivers identified the need for more information about urinary diversion choice, cystectomy education, expectations about recovery, and impacts of cystectomy and urinary diversion [12]. Qualitative research using grounded theory approaches can provide these needed insights into common experiences, trajectories and transitions in illness experience [13] for bladder cancer patients undergoing cystectomy.…”

Section: Introductionmentioning

confidence: 99%

Recovering from Cystectomy: Patient Perspectives

McMullen

Kwan

Colwell

et al. 2019

BLC

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Background: Bladder cancer patients who undergo cystectomy and urinary diversion face functional and quality-of-life challenges. Little is known about these patients’ experiences during decision-making, surgery, and recovery, or how they vary by treatment setting. Objective: To learn about patients’ experiences with treatment choice, surgical care, and recovery across health settings. Understanding patient experiences is essential to closing care gaps and developing patient-reported measures. Methods: We conducted focus groups with cystectomy patients and family caregivers at a large comprehensive health care system (N = 32 patients) and an NCI-designated comprehensive cancer center (N = 25 patients and 5 caregivers). Using standard qualitative methods, we identified themes that are not well-represented in existing research. Results: Across both systems, patients described variable experiences in decision-making about their cystectomy and urinary diversion. Some felt overwhelmed by information; others felt poorly informed. Many found self-care equipment challenging; many felt they knew little about what to expect regarding chemotherapy, recovery, and transitioning home. At times, health care personnel could not help manage patients’ ostomies or catheterization equipment. Our study also contributes a grounded theoretical framework for describing meaningful domains of patient experience with cystectomy and urinary diversion. We identified a common trajectory that includes decision-making, surgery and post-operative recovery, mastery of self-care, and reintegration. Conclusions: Patients with radical cystectomy and urinary diversion report a wide variety of experiences not captured by quantitative measures. These findings demonstrate that many cystectomy patients could benefit from additional post-operative support. We offer a framework to measure patient-centered domains in future research.

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Patient‐centered prioritization of bladder cancer research

Cited by 45 publications

References 7 publications

Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle‐invasive bladder cancer in a multisite, community‐based cohort

Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle‐invasive bladder cancer in a multisite, community‐based cohort

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

Recovering from Cystectomy: Patient Perspectives

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