Patient‐controlled analgesia: a double‐blind study in burn patients

Choinière, Manon; Grenier, Raymond; Paquette, C.

doi:10.1111/j.1365-2044.1992.tb02266.x

Cited by 62 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the 5 acutely burned patients, morphine at a mean dose of 3.1 mg/h for a mean of 28.3 hours (range, 9.5-72 hours) was also reported to give good results. Choiniere et al (8) compared IV PCAmorphine to intermittent as-needed IV morphine in 24 adult burn patients in a double-blinded study. Although the amount of morphine was similar between study groups, the group receiving IV PCA-morphine reported better pain relief compared with the control group.…”

Section: Anesth Analgmentioning

confidence: 99%

Patient-Controlled Analgesia with Fentanyl for Burn Dressing Changes

Prakash

Fatima

Pawar

2004

Anesthesia & Analgesia

View full text Add to dashboard Cite

In this randomized, double-blinded study in 60 ASA I or II adults with >20% body-surface area thermal burns, we investigated the feasibility of patient-controlled analgesia (PCA) with fentanyl for pain management during dressing changes and determined the optimal PCA-fentanyl demand dose. An initial loading dose of IV fentanyl 1 microg/kg was administered. Patients received on-demand analgesia with fentanyl (10, 20, 30, and 40 microg) whenever their visual analog scale (VAS) score was >2. Mean VAS scores in the 10 and 20 microg groups (7.73 +/- 1.33 and 7.20 +/- 1.21, respectively) were significantly higher than those in the 30 and 40 microg groups (4.47 +/- 0.83 and 3.90 +/- 0.63, respectively) (all P = 0.000). Demand/delivery ratios were significantly larger in the 10 and 20 microg groups (3.03 +/- 1.06 and 2.54 +/- 0.49, respectively) than those in the 30 and 40 microg groups (1.36 +/- 0.34 and 1.37 +/- 0.36, respectively) (all P = 0.000). VAS scores and demand/delivery ratios were comparable in the 30 and 40 microg groups (P = 0.260 and P = 0.977, respectively), which suggests comparable analgesic efficacy. There was no hemodynamic instability or respiratory depression. The optimal demand dose of PCA-fentanyl was 30 microg (5-min lockout interval) after an initial loading dose of IV fentanyl 1 microg/kg.

show abstract

Section: Anesth Analgmentioning

confidence: 99%

Patient-Controlled Analgesia with Fentanyl for Burn Dressing Changes

Prakash

Fatima

Pawar

2004

Anesthesia & Analgesia

View full text Add to dashboard Cite

show abstract

“…To this end, IV PCA has been shown to be safe and effective. 476 Absorption of IM and transdermal opioids is variable because of decreased tissue perfusion and uptake, which makes these routes unsuitable in this patient population. However, gastrointestinal absorption and emptying appear to be unchanged.…”

Section: Opioids In Patients With Burn Injurymentioning

confidence: 99%

Postoperative Pain and Other Acute Pain Syndromes

Hanna

Ouanes

Tomas

2014

Practical Management of Pain

View full text Add to dashboard Cite

“…To this end, IV PCA has been shown to be safe and effective. 312 The absorption of IM and transdermal opioids is variable due to decreased tissue perfusion and uptake, making these routes unsuitable in this patient population. Gastrointestinal absorption and emptying appear to be unchanged, however.…”

Section: Opioids In the Setting Of Burn Injurymentioning

confidence: 99%