Patient Discomfort during Carotid Artery Stenting: A Comparison Study between Iodixanol versus Iopamidol

Borrelli, Maria; Setacci, Francesco; Donato, Gianmarco de; Galzerano, G; Benevento, Domenico; Mele, Mariagnese; Rosadini, D; Messina, Gabriele; Setacci, Carlo

doi:10.1016/j.avsg.2016.04.018

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…erefore, in this study, QRHZD was used as the carrier of bitterness to evaluate the taste-masking e ect, characteristic chromatography analysis, and pharmacological e ects of three avors of CMD-Ms after optimization. Currently, the commonly used taste evaluation methods for volunteers in the world include the "single sample comparative evaluation method" [24], "bitterness value grade evaluation method" [25], "integrated score evaluation method(ISEM)" [26], "fuzzy mathematics comprehensive evaluation method" [27], "visual analog scale method" [28], "multifactor survey evaluation method" [29], "measurement matching + amplitude marking evaluation method" [30], and "taste magnetic resonance imaging evaluation method" [31]. Each method has its own unique advantages.…”

Section: Discussionmentioning

confidence: 99%

Study on Masking the Bitterness of Chinese Medicine Decoction-Mate

Hou

Miao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Traditional Chinese medicine decoction (TCMD) is an oral liquid made by decocting crude medicinal compounds with water. It has complex compositions and diverse odor and taste, most of which have an unacceptable level of bitterness which seriously affects patients’ medication compliance. To solve this problem, a variety of taste-masking pathways and different types of taste-masking excipients were combined, using the application of coffee-mate to mask the bitterness of coffee as an existing example. Three composite taste-masking adjuvants were developed to improve the taste of TCMD, referred to as the Chinese Medicine Decoction-Mate (CMD-M). However, whether CMD-M has a good taste-masking effect and whether it affects the chemical compositions and pharmacological effects of the medicine remain unclear. Method. The commonly used pediatric medicine Qingre Huazhi Decoction (QRHZD) and the personalized decoctions used in clinical practices were used as the masking research carriers. The taste-masking effect of CMD-M on QRHZD was evaluated by both healthy volunteers and an electronic tongue, and the personalized decoctions were evaluated by clinical subjects. The changes of chemical components of QRHZD before and after taste-masking were evaluated by HPLC. The changes in anti-inflammatory effects were evaluated by establishing mice as an acute inflammatory model. Results. The taste-masking effect evaluation results showed that the bitterness of QRHZD was significantly reduced after adding CMD-M. There was no significant difference in the relative peak areas change rate and total peak areas ratio of common peaks of QRHZD before and after taste-masking ( P > 0.05 ), shown by HPLC analysis. The inhibitory rates of QRHZD on ear swelling in mice before and after taste-masking also showed no significant difference ( P > 0.05 ). Conclusions. CMD-M can effectively mask the bitterness of decoctions while bringing no significant difference overall in chemical compositions and pharmacological effects before and after QRHZD masking.

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Section: Discussionmentioning

confidence: 99%

Study on Masking the Bitterness of Chinese Medicine Decoction-Mate

Hou

Miao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In the present study, we demonstrate that contrast type may have important implications in peripheral interventions. IOCM is often preferred for peripheral angiography 28 as it causes less patient discomfort as compared with LOCM, especially in patients with CLI 29,30 . Decreasing patient discomfort 21 may facilitate more optimal revascularization with higher likelihood of limb salvage, due to less patient movement resulting in better image quality 21 .…”

Section: Discussionmentioning

confidence: 99%

Use of iso‐osmolar contrast media during endovascular revascularization is associated with a lower incidence of major adverse renal, cardiac, or limb events

Prasad

Amin

Ryan

et al. 2021

Cathet Cardio Intervent

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Objective: We examined the association of iso-osmolar contrast media (IOCM) versus low-osmolar contrast media (LOCM) with major adverse renal, cardiovascular, or limb events in patients at high-risk of acute kidney injury (AKI) undergoing peripheral endovascular procedures.Background: Procedural characteristics including iodinated contrast type and volume have been associated with adverse renal and cardiovascular outcomes in patients undergoing angiographic interventions.Methods: Patients at high-risk of AKI, undergoing peripheral endovascular procedures were identified using the Premier Healthcare Database and separated into claudication and critical limb ischemia (CLI) cohorts. For each cohort, we compared IOCM versus LOCM for the primary endpoint of MARCE (major adverse renal or cardiovascular events) and secondary endpoints of major adverse renal events (MARE) and major adverse renal and limb events (MARLE). These outcomes were captured within the indexed hospitalization via adjusted multivariable regression analyses.Results: Two procedure-based cohorts of high-risk patients were formed: claudication (N = 11,976) and CLI (N = 8713). Use of IOCM was associated with a significant absolute risk reduction (ARR) of 2.2% (p < 0.0001) for MARCE overall and in each cohort (claudication, 1.8%, p = 0.0070; CLI, 2.7%, p = 0.0054). The incidence of MARE and MARLE in the overall cohort was also lower with the use of IOCM: MARE (ARR = 1.4%, p = 0.0072) and MARLE (ARR = 2.0%, p = 0.0043).Conclusions: Using IOCM versus LOCM in patients at high-risk of adverse renal events undergoing peripheral endovascular procedures was independently associated with lower risk of MARCE, MARE, and MARLE.

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“…10 mL of the solution was placed in the mouths of the volunteers for 15 s. They also gargled to allow the tongue to fully feel the bitterness. Then, the volunteers gave a score based on a visual analogue scale. − The bitter sensory score scale for the volunteers is shown in Figure A. The next sample needed to be tested more than 15 min apart later so that there was no bitterness in the mouth.…”

Section: Materials and Methodsmentioning

confidence: 99%

Amphiphilic Block Copolymers: A Novel Substance for Bitter-Masking in Aqueous Solutions

Yin

et al. 2020

Mol. Pharmaceutics

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It is a challenging task to suppress the bitterness of liquid preparations, especially for children. Bitter molecules are highly dispersible in liquids, leading to a strong and instant stimulation of the bitter receptors. At present, there is no effective way to correct this issue except for adding sweeteners, resulting in an unsatisfying taste. Based on the three-point contact theory, which is a universally accepted mechanism of bitterness formation, a new idea and application of amphiphilic block copolymers (ABCs) for bitterness suppression was proposed for the first time. We found that ABCs could widely inhibit the bitterness of four typical bitter substances. The mechanism is that ABCs self-assemble to form association colloids, which attract bitter components and reduce their distribution in the molecular form in solution. The bitter components were demonstrated to automatically embed in the spiral hydrophobic cavity of the hydrophobic chain of the ABCs, and their special interaction dispersed the positive electrostatic potential of bitter groups. The combination did not affect the pharmacokinetic parameters and pharmacodynamics of bitter drugs. These findings highlight the novel application of ABCs for the inhibition of bitterness and illuminate the underlying inhibition mechanisms.

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Patient Discomfort during Carotid Artery Stenting: A Comparison Study between Iodixanol versus Iopamidol

Cited by 5 publications

References 13 publications

Study on Masking the Bitterness of Chinese Medicine Decoction-Mate

Study on Masking the Bitterness of Chinese Medicine Decoction-Mate

Use of iso‐osmolar contrast media during endovascular revascularization is associated with a lower incidence of major adverse renal, cardiac, or limb events

Amphiphilic Block Copolymers: A Novel Substance for Bitter-Masking in Aqueous Solutions

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