Patient reported adverse events among epileptic patients taking antiepileptic drugs

Ayalew, Mohammed Biset; Muche, Esileman Abdela

doi:10.1177/2050312118772471

Cited by 30 publications

(35 citation statements)

References 34 publications

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“…Sudan, University of Gondar Referral Hospital, Tikur Anbessa Specialized Hospital, and Jimma University Medical Center all reported comparable findings. 1 , 19 , 21 , 22 Patients who have been prescribed a polypharmacy may forget to take it, or they may be unwilling or unable to take it as directed by their prescribers, resulting in non-adherence.…”

Section: Discussionmentioning

confidence: 99%

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Bekele¹

2022

PPA

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Background Non-adherence to anti-epileptic drugs (AEDs) was the most common drug therapy issue that hampered epileptic patients’ treatment success. As a result, the barriers to patients adhering to their treatment should be investigated in depth in order to prevent poor treatment outcomes. Methods A hospital-based cross-sectional study was conducted on epileptic patients who had followed up at Mettu Karl Comprehensive Specialized Hospital (MKCSH). Data collection was done through patient interview and medical charts review. Hill-Bone Compliance to High Blood Pressure Therapy Scale was used to measure medication adherence. The data were analyzed using SPSS version 23 after data were entered by Epi Info7.2.1. The multivariable logistic regressions were utilized and P < 0.05 was used to declare association. Results Over the study period, more than half of the participants 172 (57.7%) were males, and the median age of participants was 29 years. The magnitude of non-adherence to ant-epileptic drugs (AEDs) was 120 (40.27%). The results of multivariable analysis revealed that patients who had experienced the medication side effects, adjusted odds ratio (AOR) = 2.199; 95% CI: 1.21, 4.00, P = 0.010, a poly-pharmacy, adjusted odds ratio (AOR) = 5.166; 95% CI: 2.63, 10.14, P = <0.001 and the presence of a co-morbidity, adjusted odds ratio (AOR) =3.70; 95% CI: 2.058, 6.65, P = <0.001 were the predictors of medication non-adherence. Conclusion The magnitude of non-adherences to AEDs was found to be high. Phenobarbitone was the most prescribed AEDs. The number of medications taken by the patients, the presence of co-morbidity and the occurrence of medication side effects had a significant association with non-adherence to AEDs. Therefore, the pharmaceutical care in general and drug information services in particular should be established to enhance medication adherence in our study area.

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Section: Discussionmentioning

confidence: 99%

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Bekele¹

2022

PPA

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“…These adverse effects include idiosyncratic reactions, respiratory depression and different neurocognitive effects. 6 …”

Section: Introductionmentioning

confidence: 99%

Treatment outcome and associated factors among epileptic patients at ambulatory clinic of Mettu Karl Comprehensive Specialized Hospital: A cross-sectional study

Bekele¹,

Gezimu²

2022

SAGE Open Medicine

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Objective: The study was aimed to assess the magnitude and associated factors of 2-year seizure-free status of epileptic patients at Mettu Karl Comprehensive Specialized Hospital (MKCSH). Methods: A retrospective cross-sectional study was conducted at MKCSH from 12 February 2020 to 11 August 2020. Treatment outcome was measured in terms of seizure control status and seizure frequency. Accordingly, good treatment outcome was declared if the patients had a 2-year seizure-free status and poor if the patient had episodes of seizure in the last 2 years. The pharmaceutical care network Europe guideline was used to assess the presence of medication-related problems. Multivariable logistic regression was used to analyze the variables by using crude odds ratio (COR) and adjusted odds ratio (AOR) with 95% confidence interval (CI). Finally, the predictors of epilepsy treatment outcome were declared if a P-value was ⩽0.05. Results: Over the study period, more than half of the participants (172 (57.7%)) were males. The median age of participants was 29 and majorly distributed to 18–30 classes. More than one-fourth of the patients were suffering from absent seizure 85 (28.5%) and general tonic-clonic seizure 83 (27.9%). The most commonly prescribed medication was Phenobarbitone which accounts 34 (11.41%), whereas Valproic acid 8 (2.68%) was the least prescribed. Overall, less than half 131 (43.96%) of patients developed poor treatment outcomes. The predictors of treatment outcomes were having head the injury (AOR = 5.7; 95% CI: 3.18, 10.31), family history of epilepsy (AOR = 5.6; 95% CI: 3.07, 10.46) and the presence of drug therapy problems (AOR = 5.2; 95% CI: 2.79, 9.69). Conclusion: The magnitude of poor epilepsy treatment outcome was found to be high. The predictors of epilepsy treatment outcome were the history of head injury, family history of epilepsy and drug therapy problems. Therefore, to improve the treatment outcome of epileptic patients, health care providers should pay close attention to the identified factors. Besides this, the clinical pharmacy service should be implemented to minimize any medication-related problems

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“…A Cross-sectional study in Gondar was done on 354 adult epileptic patients and a total of 79 adverse events were reported. The most frequently encountered adverse events were fatigue, gastrointestinal disturbance and sedation/depression [4].…”

Section: Patients and Health Care Professionals Do Not Alwaysmentioning

confidence: 99%

Longitudinal Count Data Analysis of Factors Affecting Epileptic Seizure of Patients in Case of Gondar Referral Hospital, Northwest Ethiopia

Regesa¹,

Mekebo²

2020

BIO

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Patient reported adverse events among epileptic patients taking antiepileptic drugs

Cited by 30 publications

References 34 publications

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Treatment outcome and associated factors among epileptic patients at ambulatory clinic of Mettu Karl Comprehensive Specialized Hospital: A cross-sectional study

Longitudinal Count Data Analysis of Factors Affecting Epileptic Seizure of Patients in Case of Gondar Referral Hospital, Northwest Ethiopia

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