Patient-reported menstrual and obstetric outcomes following hysteroscopic adhesiolysis for Asherman syndrome

Abstract

Objective: Review the menstrual and obstetric outcomes among Asherman syndrome patients when stratified by disease severity. Design: Retrospective cohort study. Setting: A community teaching hospital affiliated with a large academic medical center. Patients: A total of 355 Asherman syndrome patients stratified by March classification who underwent hysteroscopic adhesiolysis. Interventions: Telephone survey, analyzed with multivariable analysis. Main Outcome Measures: Return of menstruation. Pregnancy, miscarriage, and live birth rate. Results: A total of 355 patients underwent hysteroscopic adhesiolysis. Of these, 150 (42.3%) patients completed the telephone survey with a mean follow-up of 2.21 years. Additionally, 40.7% had mild, 52.7% had moderate, and 6.6% had severe disease. Furthermore, 25.3% of patients reported amenorrhea at presentation, with mild disease patients having the highest rate of returning menstruation (93.8%) following treatment. The cumulative pregnancy rate was 81.9%, and the cumulative live birth rate was 51.2%, with no statistical differences identified by the classification group. Conclusion: Asherman syndrome disease severity predicted returning menstruation but not pregnancy or live birth rate. (Fertil Steril Rep Ò 2021;2:118-25. Ó2021 by American Society for Reproductive Medicine.

Will Procreation Ever Be The Same After COVID-19?

“…Several published reports claimed that the purported similarity between syncytin-1 and the SARS-CoV-2 spike protein may induce immune cross-reactivity resulting in female sterility [ 10 , 11 ]. Morris used frozen embryo transfer as a model for comparing the implantation rates between SARS-CoV-2 vaccine seropositive, infection seropositive, and seronegative women [ 5 ]. No difference was found in serum beta hCG documented implantation rates or sustained implantation rates between the three groups.…”

“…No difference was found in serum beta hCG documented implantation rates or sustained implantation rates between the three groups. The author concluded that reports claiming that COVID-19 vaccines or illness cause female sterility are unfounded [ 5 ].…”

“…University of Miami’s study [ 4 ] was published as a Letter to the Editor on June 17, 2021, in the Journal of the American Medical Association which shows the COVID-19 vaccine does not affect sperm count. In addition, Fertility and Sterility published a study in July 2021 [ 5 ] that concluded the COVID-19 vaccine does not result in female sterility. Both studies should reassure the public about the safety of the mRNA American technology COVID-19 vaccine [ 4 , 5 ].…”

“…In addition, Fertility and Sterility published a study in July 2021 [ 5 ] that concluded the COVID-19 vaccine does not result in female sterility. Both studies should reassure the public about the safety of the mRNA American technology COVID-19 vaccine [ 4 , 5 ]. ASRM maintains its position and guidelines that vaccination is the best way to avoid getting or transferring the COVID-19 coronavirus and should not dissuade anyone from building or adding to their family [ 6 ].…”

Visual Analysis of Uterine Adhesion Research Based on CiteSpace: Bibliometric Analysis From 2006 to 2021

“…Intrauterine adhesion (IUA) was first proposed by Heinrich Fritsch in 1894 ( 1 ), and Joseph G Asher-Man published a series of papers in 1948 to name the disease and describing it in detail, so it is also called Asherman syndrome ( 2 ). IUA is a common intrauterine disease, referring to adhesion or even occlusion of uterine isthmus and cervical canal caused by various reasons ( 3 – 5 ).…”