BackgroundIntrauterine adhesionis caused by a variety of reasons, such as damage of the endometrial basal layer, adhesion or occlusion of the uterine cavity or cervix in different degrees. Seriously endangering women's physical and mental health.ObjectiveThe purpose of this paper is to analyze the research development of intrauterine adhesions in recent 15 years, explore the future development direction, and promote the development of this field.MethodsWith intrauterine adhesions and Ashman's syndrome as the theme, the related literatures from January 2006 to July 2021 in the Web of Science were searched, and the visual atlas was analyzed by CiteSpace software.ResultsA total of 644 literatures were included. The key words related to intrauterine adhesion mainly include adhesion, pregnancy, expression, intrauterine adhesions, women, adhesion molecule, diagnosis, activation, hysteroscopy and fertility, etc. Six clusters were obtained by keywords analysis, involving hysteroscopy, placenta, office hysteroscopy, uterus and laparoscopy. Co-occurrence of keywords shows that the research focus in recent years is on endometrial repair and regeneration.ConclusionsThrough the bibliometric analysis of WOS research on intrauterine adhesions in recent 15 years, the comprehensive analysis of countries, institutions, authors and keywords is obtained, which has a clear guiding significance for guiding the future development of intrauterine adhesions.

Background Intrauterine adhesionis caused by a variety of reasons, such as damage of the endometrial basal layer, adhesion or occlusion of the uterine cavity or cervix in different degrees.Seriously endangering women's physical and mental health. Objective The purpose of this paper is to analyze the research development of intrauterine adhesions in recent 15 years, explore the future development direction, and promote the development of this field. Methods With intrauterine adhesions and Ashman's syndrome as the theme, the related literatures from January 2006 to July 2021 in the Web of Science were searched, and the visual atlas was analyzed by CiteSpace software. Results A total of 644 literatures were included. The key words related to intrauterine adhesion mainly include adhesion, pregnancy, expression, intrauterine adhesions, women, adhesion molecule, diagnosis, activation, hysteroscopy and fertility,etc.Six clusters were obtained by keywords analysis, involving hysteroscopy, placenta, office hysteroscopy, uterus and laparoscopy. Co-occurrence of keywords shows that the research focus in recent years is on endometrial repair and regeneration. Conclusions Through the bibliometric analysis of WOS research on intrauterine adhesions in recent 15 years, the comprehensive analysis of countries, institutions, authors and keywords is obtained, which has a clear guiding significance for guiding the future development of intrauterine adhesions.

Background: Epidemiological studies have found, the occurrence of endometrial cancer (EC) is closely related to metabolic diseases, and insulin resistance (IR) plays an important role in the pathogenesis of endometrium, but the specific pathogenesis is still unclear. The purpose of this study is to reveal the relationship between insulin resistance and endometrial carcinoma. Methods: We analyzed one endometrial carcinoma database (GSE106191) and one insulin-resistant database (GSE63992), with GEO database and Venny online analysis tool, and P-value< 0.05 was thought about as statistically significant, then, we found an add-up to 148 different genes. Functional enrichment analysis of these genes using DAVID showed that they were participated in transcription factor activity, signaling pathways and response to factors, etc. Then used Cytoscape to establish Protein-Protein Interaction network, and got 25 hub genes. Then further analyzed the expression differences, histological differences, survival analysis, immune infiltration and genetic alteration of 25 hub genes.Results: Of the 25 hub genes, 9 hub genes (KLF5, BRD4, E2F2, LYN, HES1, YY1, IGSF3, TRAF3 and GJB3) were over-expressed in endometrial carcinoma, 11hub genes (TRO, NEURL2, PTEN, RARA, RYBP, OGT, FBXW7, PIK3C3, PIK3C2B, ING3 and DDX58) were under-expressed, and there were no significant difference among 5 hub genes (MYL12A, RAD21, TGFBRAP1, IRAK2 and PTPN1).The results showed that the survival time of patients expressing OGT, IGSF3, TRO, NEURL2 and PIK3C2B may be significantly and closely related to EC, and the percentage of gene changes of five central genes ranged from 3% to 10% of a single gene, was also related to the infiltration of seven kinds of immune cells in endometrial carcinoma.Conclusion: The five key genes (OGT, IGSF3, PIK3C2B, TRO and NEURL2) may be involved in immune infiltration in the progression of endometrial carcinoma, and there is also a certain mutation probability in gene mutation. Insulin resistance may be a trigger in the pathogenesis of endometrial cancer.

Introduction:Epidemiological studies have found that the occurrence of endometrial cancer(EC) is closely related to metabolic diseases, and insulin resistance (IR) plays an important role in the pathogenesis of endometrium, but the specific pathogenesis is still unclear. The purpose of this study is to reveal the relationship between insulin resistance and endothelial cells by gene screening technology. Material and methods:We analyzed one endometrial carcinoma database (GSE106191) and one insulin-resistant database (GSE63992), with Gene Expression Omnibus (GEO) database and Venny online analysis tool, then, we found an add-up to 148 different genes. Functional enrichment analysis of these genes using DAVID showed that they were participated in transcription factor activity,signaling pathways and response to factors, etc. Then used cytoHubba in Cytoscape,we got 25 hub genes.Results: The results showed that the survival time of OGT, IGSF3, TRO, NEURL2 and PIK3C2B was significantly and closely related to EC, and the percentage of gene changes of five central genes ranged from 3% to 10% of a single gene, was also related to the infiltration of seven kinds of immune cells in endometrial carcinoma.Conclusion:The five key genes (OGT,IGSF3, PIK3C2B,TRO and NEURL2) are involved in immune infiltration in the progression of endometrial carcinoma, and there is also a certain mutation probability in gene mutation. This may be the pathogenesis of insulin resistance and endometrial cancer.