Patient‐reported outcome measures in recurrent aphthous stomatitis: A critical assessment of quality properties

Wiriyakijja, Paswach; Fedele, Stefano; Porter, Stephen; Mercadante, Valeria; Ríordáin, Rícheal Ní

doi:10.1111/odi.12726

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…One example is the extensive usage of the shortened 14-item Oral Health Impact Profile (OHIP-14) 18 in oral mucosal disease literature. Two recent reviews found significantly higher frequency of use of the OHIP-14 than its original lengthy version (OHIP-49) as outcome measures in previous research of OLP (12 times use of the OHIP-14 compared to 6 for the OHIP-49) and RAS (9 times use of OHIP-14 compared to one study for the OHIP-49) 19,20 . Considering the importance of measuring patient's QoL in oral mucosal diseases, the development of COMDQ-15 could improve implementation of this instrument in both clinical and research settings.…”

Section: Accepted Articlementioning

confidence: 93%

Development and validation of a short version of Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15)

Wiriyakijja

Porter

Fedele

et al. 2019

J Oral Pathology Medicine

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Background:The adoption of the Chronic Oral Mucosal Disease Questionnaire (COMDQ) into clinical practice has been low, despite its rigorous development process. A potential limitation of the COMDQ is the high response burden to patients. Therefore, the aim of the present study was to develop and validate a short version of the 26-item COMDQ. Methods:The COMDQ data of 520 patients with chronic oral mucosal diseases were randomly divided into 2 subsamples. Descriptive item analysis and exploratory factor analysis (EFA) were performed using data from the first subsample for item reduction and development of the shortened COMDQ. The resulting short version was then validated using confirmatory factor analysis (CFA) on the other subsample. Internal consistency reliability of the short-form COMDQ was assessed using Cronbach's alpha. Criterion validity of this new scale was examined against its original version. Results:Based upon item analysis, 11 items were dropped. EFA results on the remaining 15 items extracted 4 factors consistent with the original COMDQ, and CFA results displayed acceptable goodness-of-fit indices of this factor structure on different sample. The COMDQ-15 was then created. Cronbach's alpha of 4 subscale scores ranged from 0.7 to 0.91, indicating good internal consistency reliability of the COMDQ-15.Correlations between total and subscale scores of the COMDQ-15 and its parent scale were high, supporting good criterion validity of this shortened scale. Conclusion:The COMDQ-15 is a brief, valid and reliable instrument that can give an overview of the patient's quality of life related to their chronic oral mucosal conditions.

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Section: Accepted Articlementioning

confidence: 93%

Development and validation of a short version of Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15)

Wiriyakijja

Porter

Fedele

et al. 2019

J Oral Pathology Medicine

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“…7 (5,8) .05 c 5 (3,6) 7 (5,8) .0019 c USS-total 29 (24,35) 29 (24,35) 29 (25,36) .586 a 28.5 (24,35) 33 (25,38) .217 a 29 (24,34) 30 (24,38) .326 a 28 (21, 32) 29 (25,36) .…”

Section: (3 7)mentioning

confidence: 99%

“…Although previous studies have suggested that psychological factors such as stress and anxiety may be associated with the clinical manifestations of RAS in some affected individuals, the nature and determinants of this association remain unclear. In addition, little is known regarding the validity and reliability of the self‐assessment psychological scales that have been employed in previous studies in this patient population, which raises concerns regarding the appropriateness of these tools in exploring the psychological factors associated with RAS, as well as the accuracy of available results.…”

Section: Introductionmentioning

confidence: 99%

Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

Wiriyakijja

Porter

Fedele

et al. 2020

J Oral Pathology Medicine

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Objectives To validate the Hospital Anxiety and Depression Scale (HADS) and the 10‐item Perceived Stress Scale (PSS‐10) for use in clinical studies of recurrent aphthous stomatitis (RAS) and to provide cross‐sectional assessment of anxiety, depressive, and distress symptoms and perceived stress in patients with RAS. Methods The validity and reliability of the HADS and PSS‐10 were evaluated in 120 individuals with RAS through confirmatory factor analysis and calculation of Cronbach's alpha and omega coefficients. The prevalence of comorbid anxiety, depression, distress, and moderate‐to‐high perceived stress, and their association with demographics and clinical factors were assessed through cutoff scores of the HADS and PSS‐10 and bivariate analyses, respectively. Results A bi‐factor model, with all items loading onto general factor with two group factors, provides the best fit to the HADS and PSS‐10 data of this RAS cohort. While omega values suggested adequate reliability of total score of both scales, relatively low ranges of coefficient omega hierarchical limit utility of their subscale scores. The prevalence of anxiety, depression, distress, and moderate‐to‐high perceived stress was 42.5%, 18.33%, 28.33%, and 71.67%, respectively. Ethnicity, alcohol consumption, disease comorbidities, clinical type of RAS, ulcer size, pain, and RAS disease activity were found to be associated with negative psychological symptoms. Conclusion The HADS and PSS‐10 are valid and reliable as general scales of psychological distress and stress in patients with RAS. Significant mental burden among RAS patients makes the use of these validated instruments a sensible and prudent practice for psychological assessment of this patient group.

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“…[12][13][14]20,21,29,30 24 Türk RAS'lı hastalarda geçerli ve güvenilir bir ölçüt olduğu kanıtlanan bu ölçek RAS'lı hastalarda ulusal ve yabancı yayınlarda en sık kullanılan hasta bildirimli çıktı ölçeklerinden biridir. 2,[12][13][14][15]17,18,21 RAS'lı hastalarda yapılan çalışmalar gözden geçirildiğinde RAS'ın klinik olarak değerlendirilmesinde hasta öyküsü ve klinik muayenenin kullanıldığı görülmektedir. Çalışmada, Tappuni ve ark.…”

Section: Veri Toplama Araçlarıunclassified

“…Klinisyenler tarafından yapılan normatif değerlendirmeden farklı olan hastanın sübjektif hastalık algısına odaklanan bu yeni yaklaşım, klinisyenlere klinik karar verme sürecinde, etkin sağlık hizmetlerinin planlanmasında ve klinisyen-hasta iletişiminin artırılmasında yarar sağlamaktadır. 1,2 Bu bağlamda ağız sağlığına bağlı yaşam kalitesi ölçekleri, ağız hastalıklarının negatif sonuçlarının anlaşılmasında ve belirlenmesinde klinisyenlere yol göstermektedir. 3 Kronik ağız mukozası lezyonları hastanın fiziksel sağlığını, günlük fonksiyonlarını ve geleceğe yönelik endişe düzeylerini etkilemektedir.…”

Section: Introductionunclassified

The evaluation of oral health related quality of life in patients with recurrent aphthous stomatitis

Gürleyen¹,

Peker²,

Ak³

2018

Yeditepe J Dent

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Bu çalışmanın amacı, rekürrent aftöz stomatitli (RAS) hastalarda ağız sağlığına bağlı yaşam kalitesinin değerlendirilmesi ve belirleyenlerinin tespit edilmesidir. Gereç ve Yöntem:Bu kesitsel çalışmanın örneklemini RAS tanısı konulan gönüllü 85 hasta oluşturmaktadır. Veriler sosyo-demografik, davranışsal, klinik değişkenler ile Ağız Sağlığı Etki Ölçeği (OHIP-14)'nin yer aldığı anket formu aracılığı ile toplanmıştır. Ülserlerin klinik özelliklerinin değerlendirilmesinde Ülser Şiddeti Skorlaması (USS) kullanılmıştır. Verilerin analizinde tanımlayıcı istatistik, Mann-Whitney U test, Spearman korelasyon katsayısı ve çoklu doğrusal regresyon analizi kullanılmıştır. Bulgular:Çalışmada 35'i kadın (%41,2), 50'si erkek (%58,8), ortalama yaşı 39,17±14,29 olan toplam 85 hasta yer almaktadır. Cinsiyet (p=0,001) ve medeni durum (p=0.044) açısından OHIP-14'ün psikolojik rahatsızlık alt ölçeğinde anlamlı fark bulunmuştur. Çalışma durumu, eğitim, sigara ve alkol kullanımı açısından OHIP-14 toplam puan ve alt ölçek puanlarında anlamlı fark saptanmamıştır. İkili analizlerde, OHIP-14 toplam puanı ile aile öyküsü, ülser süresi, sıklığı, ağrı düzeyi, toplam USS skoru ve hastalık süresi arasında anlamlı ilişki bulunmuştur. Çok değişkenli regresyon analizinde; USS toplam puanı (ß=0.635; p<0,001), ağız sağlığı algısı (ß=0.285; p<0,05) ve medeni durum (ß=0.232; p<0.05) yaşam kalitesindeki toplam varyansın %25'ini açıklayan en önemli belirleyen olarak bulunmuştur. Sonuç:Minör RAS'lı hastalarda ağız sağlığına bağlı yaşam kalitesinin en önemli belirleyeni olarak USS, ağız sağlığı algısı ve medeni durum bulunmuştur. Rutin klinik uygulamalarda OHIP-14'ün, ağız sağlığı algısı, sosyo-demografik özellikler ve USS'nin sübjektif sağlığın ölçümlenmesinde birlikte kullanılması fayda sağlayacaktır. Anahtar kelimeler:Rekürrent aftöz stomatit, ağız sağlığına bağlı yaşam kalitesi, ülser şiddeti, sosyo-demografik, davranışsal SUMMARY Aim:The aim of the study was to assess the oral health-related quality of life in patients with recurrent aphthous stomatitis (RAS) and to determine its predictors. Materials and Methods:The study sample of this cross-sectional study was 85 volunteers with RAS. Data was collected via a questionnaire including socio-demographic, behavioral and ulcer characteristics and Oral Health Impact Profile 14 (OHIP-14). Ulcer characteristics was evaluated by using Ulcer Severity Score (USS). Data analysis was performed by using descriptive statistics, Mann-Whitney U test, Spearman correlation coefficients and the multiple linear regression. Results:A total of 85 patients of whom 35 were females (%41.2), 50 were males (%58.8) with a mean age of 39.17±14.29 years were enrolled. Regarding the psychological discomfort domain of OHIP-14 gender and marital status were statistically ÖZGÜN ARAŞTIRMA

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Patient‐reported outcome measures in recurrent aphthous stomatitis: A critical assessment of quality properties

Abstract: There was a wide range of PROMs used in clinical studies of RAS. The majority of these PROMs lack evidence of measurement properties and interpretability for RAS patients. Further studies are required to confirm whether these instruments are suitable and useful for this patient group.

Cited by 8 publications

References 28 publications

Development and validation of a short version of Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15)

Development and validation of a short version of Chronic Oral Mucosal Disease Questionnaire (COMDQ‐15)

Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

The evaluation of oral health related quality of life in patients with recurrent aphthous stomatitis

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