Patient-reported outcomes of psoriasis improvement with etanercept therapy: results of a randomized phase III trial

Krueger, Gerald G.; Langley, Richard; Finlay, A.Y.; Griffiths, C.E.M.; Woolley, J. Michael; Lalla, Deepa; Jahreis, Angelika

doi:10.1111/j.1365-2133.2005.06948.x

Cited by 122 publications

(122 citation statements)

References 15 publications

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“…Of patients achieving PASI-75 at 12 weeks at the higher dose, 77% maintained PASI-75 at 24 weeks after 12 weeks of treatment with the lower dose; 32% of 88 patients who did not achieve PASI-75 at 12 weeks did so at 24 weeks [23]. DLQI remained constant at 12 and 24 weeks in patients originally treated with the higher dose [41].…”

Section: Efficacy Etanerceptmentioning

confidence: 90%

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Janknegt¹

2016

J Pharma Care Health Sys

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The treatment of plaque psoriasis is changing because of the introduction of new treatment options. The goal of this article is to allow a transparent and rational choice of medicines by means of the System of Objectified Judgement Analysis. The following selection criteria (relative weight) were applied: approved indications (40), drug interactions (60), clinical efficacy (400), safety (300), dosage frequency (100) and documentation (100). Acquisition cost was not taken into consideration to allow a preselection on quality aspects only. Adalimumab, etanercept, infliximab and ustekinumab were compared on these criteria. Infliximab and ustekinumab showed the highest scores and are the most suitable medicines for the treatment of severe plaque psoriasis. Of course, cost will play a key role in the final selection in individual hospitals. Weight Approved indications 40 Drug Interactions 60Clinical efficacy 400Safety 300Dosage frequency 100 Documentation 100Total 1000 Selection Criteria Approved IndicationsThe number of licensed indications is a good measure of the applicability and documentation of the drugs. Although this analysis is limited to the treatment of plaque psoriasis, the fact that a drug is approved for (almost) all indications listed below is, from a formulary point of view, advantageous to another drug, which is approved for only one or two applications.The percentage of the maximum score for approved indications was obtained as follows (Table 2): IndicationMaximum Score (%)Plaque psoriasis 50% Psoriatric arthritis 20%Rheumatoid arthritis 10% Spondylitis ankylopoetica 10%Inflammatory bowel disease 10% Drug interactionsInteractions play a role only in patients who use other drugs which may interact with biologicals. However, it is a relevant criterion from a formulary point of view.The score for each drug was dependent on the frequency and severity of observed drug interactions. Clinical efficacyClinical efficacy is always a very important selection criterion for any group of drugs. The score for each drug was derived from the results of double-blind comparative studies. SafetyThe extent and the severity of adverse effects is another important selection criterion for drugs. A distinction was made between "minor" side effects, such as gastrointestinal disturbances or skin reactions, occurring in clinical trials and severe or even life-threatening adverse reactions observed with large scale use of the drugs. The evaluation of the "minor" adverse effects was based on results of double blind comparative clinical studies.

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Section: Efficacy Etanerceptmentioning

confidence: 90%

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Janknegt¹

2016

J Pharma Care Health Sys

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“…20,674 articles were found, of which 20,592 were excluded, resulting in 82 articles in which 41 clinical trials comparing biologics with placebo (six adalimumab 17,18,19,20,21,22,23,24,25,26,27 , three alefacept 28,29,30,31,32,33,34,35,36,37 , one briakinumab 38,39 , one certolizumab 40 , seven efalizumab 41,42,43,44,45,46,47,48,49,50,51 , eight etanercept 52,53,54,55,56,57,58,59,60,61,62,63,64 , one golimumab 65,66 , eight infliximab …”

Section: Study Selectionmentioning

confidence: 99%

Efficacy and safety of biologics in the treatment of moderate to severe psoriasis: a comprehensive meta-analysis of randomized controlled trials

et al. 2013

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Efficacy and safety of biologics in the treatment of moderate to severe psoriasis: a comprehensive meta-analysis of randomized controlled trials Eficácia e segurança de agentes biológicos no tratamento da psoríase moderada a grave: uma meta-análise de ensaios clínicos randomizados e controlados Eficacia y seguridad de los agentes biológicos en el tratamiento de la psoriasis moderada a severa: un metaanálisis de ensayos aleatorios y controlados

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“…Thus, the finding of a stress-induced increase of leukocyte trafficking with a potentially increased influx of leukocytes into the skin could be of clinical significance, and could at least partly explain the often observed stress-induced exacerbation of psoriatic lesions. However, there is growing evidence that T cell mediated autoimmune processes and action of proinflammatory cytokines cause hyperproliferation of keratinocytes and assume the psoriatic phenotype (Krueger et al, 2005). When exposed to psychosocial stress, psoriasis patients showed increased monocyte and (activated) T cell number when compared to healthy controls.…”

Section: Psoriasis and Sam System: Aspect Of Psychoneuroimmunologymentioning

confidence: 99%

Psoriasis and Stress – Psoriasis Aspect of Psychoneuroendocrinology

Zangeneh¹,

Fazeli²,

Shooshtary³

2012

Psoriasis

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Patient-reported outcomes of psoriasis improvement with etanercept therapy: results of a randomized phase III trial

Cited by 122 publications

References 15 publications

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Efficacy and safety of biologics in the treatment of moderate to severe psoriasis: a comprehensive meta-analysis of randomized controlled trials

Psoriasis and Stress – Psoriasis Aspect of Psychoneuroendocrinology

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