Patient-Specific Computer Modeling to Predict Aortic Regurgitation After Transcatheter Aortic Valve Replacement

Jaegere, Peter de; Santis, Gianluca De; Rodríguez-Olivares, Ramón; Bosmans, Johan; Bruining, Nico; Dezutter, Tim; Rahhab, Zouhair; Faquir, Nahid El; Collas, ValÃ©rie M.; Bosmans, Bart; Verhegghe, Benedict; Ren, Claire; Geleinse, Marcel; Schultz, Carl; Mieghem, Nicolas Van; Beule, Matthieu De; Mortier, Peter

doi:10.1016/j.jcin.2016.01.003

Cited by 103 publications

(103 citation statements)

References 5 publications

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“…Two multicentre observational studies have been conducted for the clinical validation of the TAVIguide software [25, 26]. The first sought to assess the accuracy of the software to predict frame morphology, dimensions and aortic leaflet displacement after valve implantation [25].…”

Section: Methods and Resultsmentioning

confidence: 99%

“…The second study focused on the accuracy of the model for the prediction of PVL after TAVI [26]. Similar to the first validation study, pre-operative MSCT was used to generate 3D models of the aortic root of 60 patients treated with a MCS valve.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 0.80, 0.80, 0.57, 0.92 and 0.80, respectively (reference angiography) and were 0.72, 0.78, 0.35, 0.94 and 0.73 (reference echocardiography).

Fig. 4Blood flow domains including PVL channels were derived from predicted frame deformation and box plot analysis from the observed and predicted PVL [26] …”

Section: Methods and Resultsmentioning

confidence: 99%

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Patient-specific computer modelling – its role in the planning of transcatheter aortic valve implantation

Faquir¹,

Ren²,

Mieghem³

et al. 2016

Neth Heart J

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Transcatheter aortic valve implantation is increasingly used to treat patients with severe aortic stenosis who are at increased risk for surgical aortic valve replacement and is projected to be the preferred treatment modality. As patient selection and operator experience have improved, it is hypothesised that device-host interactions will play a more dominant role in outcome. This, in combination with the increasing number of valve types and sizes, confronts the physician with the dilemma to choose the valve that best fits the individual patient. This necessitates the availability of pre-procedural computer simulation that is based upon the integration of the patient-specific anatomy, the physical and (bio)mechanical properties of the valve and recipient anatomy derived from in-vitro experiments. The objective of this paper is to present such a model and illustrate its potential clinical utility via a few case studies.

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Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

Fig. 4Blood flow domains including PVL channels were derived from predicted frame deformation and box plot analysis from the observed and predicted PVL [26] …”

Section: Methods and Resultsmentioning

confidence: 99%

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Patient-specific computer modelling – its role in the planning of transcatheter aortic valve implantation

Faquir¹,

Ren²,

Mieghem³

et al. 2016

Neth Heart J

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“…Should the long-term durability of percutaneous valves approach or surpass that of conventional devices, open-heart surgery might become obsolete. The ultimate goal will be the total valve replacement not only for aortic valves but mitral and pulmonary valves as well, as it becomes possible to accommodate the specific requirements of every patient [2][3]. We are enthusiastic participants in the worldwide efforts to achieve the long-term durability of the percutaneous devices.…”

Section: Commentarymentioning

confidence: 99%

Transcatheter Heart Valve Crimping and Expansion: Commentary

Guidoin¹,

Mao²,

Zegdi³

et al. 2017

J Med Surg Pathol

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Bovine pericardium represents the material of choice to serve as leaflets but this material is fragile and mishandling might lead to dramatic consequences. The complete innocuousness of handling at implantation has not been reached as crimping and balloon inflation cause various degrees of injury. These can impair the physical characteristics and aggravate the thrombogenicity. The design of the device must promote the long-term durability of the pericardium. The role and selection of polyester fabrics as buffer between the metallic frame and the pericardium is likely to prevent major abrasion at implantation and in situ.

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“…The second study focused on the accuracy of the model for the prediction of paravalvular leakage (PVL) after TAVI 21. Similar to the first validation study, preoperative MSCT was used to generate 3D models of the aortic root of 60 patients treated with a MCS valve.…”

Section: Introductionmentioning

confidence: 99%

Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know

Jaegere

Rocatello

Prendergast

et al. 2019

Heart

Self Cite

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Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. In this paper, we describe the technical background and a number of illustrations to illustrate how patient-specific computer simulation may be used for catheter-based treatment planning of acquired heart disease.

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Patient-Specific Computer Modeling to Predict Aortic Regurgitation After Transcatheter Aortic Valve Replacement

Cited by 103 publications

References 5 publications

Patient-specific computer modelling – its role in the planning of transcatheter aortic valve implantation

Patient-specific computer modelling – its role in the planning of transcatheter aortic valve implantation

Transcatheter Heart Valve Crimping and Expansion: Commentary

Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know

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