Patient-Specific Hemodynamics of New Coronary Artery Bypass Configurations

Rezaeimoghaddam, Mohammad; Oguz, Gokce Nur; Ateş, Mehmet; Bozkaya, Tijen Alkan; Pişkin, Şenol; Lashkarinia, S Samaneh; Tenekecioğlu, Erhan; Karagöz, Haldun; Pekkan, Kerem

doi:10.1007/s13239-020-00493-9

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…A significant limitation of models employing only a lumped parameter approach is the oversimplification in representing wave propagation along the larger vessels ( 84 ); however, their advantage over 3D models is their relative computational efficiency and ease of implementation. Many of the studies that have utilised 3D models of CABG configurations have used open-source software such as ANSYS/FLUENT ( 94 – 96 ) or OpenFOAM ( 97 ) for implementation. In addition to calculating mean graft flows, these 3D models have also calculated haemodynamic stresses in the coronary circulation such as wall shear stress (WSS) and oscillatory shear index (OSI) which influence long-term graft patency ( 98 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to calculating mean graft flows, these 3D models have also calculated haemodynamic stresses in the coronary circulation such as wall shear stress (WSS) and oscillatory shear index (OSI) which influence long-term graft patency ( 98 ). Because of these focii, these research studies have tended to study saphenous vein grafts, sequential grafts, and grafting angles as the outcomes of interest for long-term patency ( 94 , 97 , 99 ). However, in practical terms, grafting angle is not particularly easy for a cardiac surgeon to control whereas WSS and OSI are markers for long-term patency that cannot be easily measured in real time by a surgeon.…”

Section: Discussionmentioning

confidence: 99%

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A predictive patient-specific computational model of coronary artery bypass grafts for potential use by cardiac surgeons to guide selection of graft configurations

Chaudhuri

Pletzer²,

Smith³

2022

Front. Cardiovasc. Med.

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Cardiac surgeons face a significant degree of uncertainty when deciding upon coronary artery bypass graft configurations for patients with coronary artery disease. This leads to significant variation in preferred configuration between different surgeons for a particular patient. Additionally, for the majority of cases, there is no consensus regarding the optimal grafting strategy. This situation results in the tendency for individual surgeons to opt for a “one size fits all” approach and use the same grafting configuration for the majority of their patients neglecting the patient-specific nature of the diseased coronary circulation. Quantitative metrics to assess the adequacy of coronary bypass graft flows have recently been advocated for routine intraoperative use by cardiac surgeons. In this work, a novel patient-specific 1D-0D computational model called “COMCAB” is developed to provide the predictive haemodynamic parameters of functional graft performance that can aid surgeons to avoid configurations with grafts that have poor flow and thus poor patency. This model has significant potential for future expanded applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A predictive patient-specific computational model of coronary artery bypass grafts for potential use by cardiac surgeons to guide selection of graft configurations

Chaudhuri

Pletzer²,

Smith³

2022

Front. Cardiovasc. Med.

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“…However, the present studies tend to focus more on comparatively severe stenosis (≥ 70%), especially the stenosis which is over 80%, without paying adequate attention to investigating the dynamic progression of hemodynamic distribution in relatively moderate and mild stenosis (< 70%) [ 8 , 20 – 23 ]. Although comparatively less severe, moderate and mild stenosis still deserve due attention and thorough investigation by the researchers due to the fact that they have the potential to pose health hazards for the patients as well.…”

Section: Introductionmentioning

confidence: 99%

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics

Zhao

Chen

Sun

et al. 2023

BMC Cardiovasc Disord

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Background and objectives Real-time blood flow variation is crucial for understanding the dynamic development of coronary atherosclerosis. The main objective of this study is to investigate the effect of varying extent of stenosis on the hemodynamic features in left anterior descending coronary artery. Methods Various Computational fluid dynamics (CFD) models were constructed with patient-specific CT image data, using actual fractional flow reserve (FFR) as boundary conditions to provide a real-time quantitative description of hemodynamic properties. The hemodynamic parameters, such as the local and instantaneous wall shear stress (WSS), oscillating shear index (OSI) and relative residence time (RRT), blood flow velocity and pressure drop during various phases of cardiac cycle were provided in detail. Results There was no evident variation in hemodynamic parameters in the cases of less than 50% stenosis while there were abrupt and dramatic changes in hemodynamics when the stenosis aggravated from 60 to 70%. Furthermore, when the stenosis was beyond 70%, there existed substantial pressure difference, WSS, and blood flow velocity in the center of the stenosis. Although OSI and RRT increased along with the aggravation of stenosis, they appeared with obvious abnormalities across all cases, even in mild stenosis. Conclusion The simulation could present a dynamic and comprehensive profile of how hemodynamic parameters vary in accordance with divergent severities of stenosis, which could serve as an effective reference for the clinicians to have a deeper insight into the pathological mechanism of coronary atherosclerosis and stenosis.

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Computational Fluid Dynamics Applications in Cardiovascular Medicine—from Medical Image-Based Modeling to Simulation: Numerical Analysis of Blood Flow in Abdominal Aorta

Totorean

Bernad

Ciocan

et al. 2022

Forum for Interdisciplinary Mathematics

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Patient-Specific Hemodynamics of New Coronary Artery Bypass Configurations

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 5 publications

References 42 publications

A predictive patient-specific computational model of coronary artery bypass grafts for potential use by cardiac surgeons to guide selection of graft configurations

A predictive patient-specific computational model of coronary artery bypass grafts for potential use by cardiac surgeons to guide selection of graft configurations

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics

Computational Fluid Dynamics Applications in Cardiovascular Medicine—from Medical Image-Based Modeling to Simulation: Numerical Analysis of Blood Flow in Abdominal Aorta

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