Patient‐Specific Self‐Powered Metamaterial Implants for Detecting Bone Healing Progress (Adv. Funct. Mater. 32/2022)

Barri, Kaveh; Zhang, Qianyun; Swink, Isaac; Aucie, Yashar; Holmberg, Kyle J.; Sauber, Ryan; Altman, Daniel T.; Cheng, Boyle C.; Wang, Zhong Lin; Alavi, Amir H.

doi:10.1002/adfm.202270180

Cited by 8 publications

(12 citation statements)

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“…[ 71 ] Besides the data logger, the team also developed a patient‐specific interbody fusion cage integrated with TENG that could self‐sense and self‐monitor for spinal applications. [ 18 ] The test results of the synthetic spine and human cadaver spine models showed that this self‐aware TENG could diagnose bone healing through the different voltages generated with TENG. [ 18 ] This pioneering study confirmed the efficiency of using this self‐aware and self‐power TENG in assessing the fusion and bone healing processes.…”

Section: Tengs For Bone‐related Sensingmentioning

confidence: 99%

“…[ 18 ] The test results of the synthetic spine and human cadaver spine models showed that this self‐aware TENG could diagnose bone healing through the different voltages generated with TENG. [ 18 ] This pioneering study confirmed the efficiency of using this self‐aware and self‐power TENG in assessing the fusion and bone healing processes.…”

Section: Tengs For Bone‐related Sensingmentioning

confidence: 99%

“…[ 8 ] For example, the interbody fusion cage integrated with TENG fabricated by Barri's team could generate 9.2 V initially, but it could only provide around 1 V after 40 000 load cycles of fatigue test. [ 18 ] The traditional method to overcome wear and erosion is to explore new materials which are more resilient, like graphene and carbon. [ 105,106 ] The life expectancy of TENGs can be significantly extended if suitable materials are adopted.…”

Section: Challenges and Future Outlookmentioning

confidence: 99%

“…Recently, there have been more and more TENG‐related applications in bone tissue engineering. [ 18 ] Generally, bone has a dynamic and complicated structure to support daily human activities, protect human organs, and ensure physiological activities. [ 19–21 ] Bone regeneration after diseases, accidents, or implantation has always been a crucial challenge, especially in severely deficient regions.…”

Section: Introductionmentioning

confidence: 99%

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Applications of Triboelectric Nanogenerators in Bone Tissue Engineering

Wang

Dai

Fuh

et al. 2023

Adv Materials Technologies

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Bioelectricity has been a fundamental property of all living organisms. With electrical stimulation, living cells can interact with their microenvironments, which makes electrical stimulation highly beneficial for various biomedical applications. However, traditional electrical stimulation mainly relies on bulky and complex equipment, which may not be ideal due to the restriction of movement, limited battery lifetime, uncomfortable wearing, and potential unfriendly to the environment. The advent of triboelectric nanogenerators (TENGs) has helped to resolve the existing limitations. TENGs are effective energy harvesting systems that use a mix of triboelectrification and electrostatic induction to create electrical energy from kinetic energy. TENGs deliver self‐powered electrical stimulation to bone cells for functional regulation or bone regeneration, serve as sensors to detect biological signals or movements, or act as a power source for other biomedical devices. TENGs can be employed in various applications, including enhancing bone regeneration, providing sensing function, slowing bone aging, and curing implant‐related infections. The recent applications of TENGs in bone tissue engineering are reviewed, and the drawbacks of the TENGs are discussed. Finally, the existing challenges and future roadmap for developing TENGs are presented.

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Section: Tengs For Bone‐related Sensingmentioning

confidence: 99%

Section: Tengs For Bone‐related Sensingmentioning

confidence: 99%

Section: Challenges and Future Outlookmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Applications of Triboelectric Nanogenerators in Bone Tissue Engineering

Wang

Dai

Fuh

et al. 2023

Adv Materials Technologies

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“…With the aging of modern population and frequent occurrence of fracture accidents, the development of a smart implant with a sufficient strength benefit and high bone tissue regeneration capability has shown a remarkable potential to revolutionize the healthcare system. [ 1–3 ] Compared with natural bone, which depending on the type, has a relatively wide elastic modulus range of 3–30 GPa, an artificial bone implant composed of polyether ether ketone (PEEK) has a significantly narrower elastic modulus range of 3–4 GPa. [ 4–6 ] Even so, it would be more useful to control the mechanical strength of the PEEK implant over a wider range to increase its similarity to natural bone.…”

Section: Introductionmentioning

confidence: 99%

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Jang

Park

Lee

et al. 2022

Adv Funct Materials

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Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional implants are optimized for use either under high mechanical load or for active osseointegration. To achieve the dual target of mechanical durability and biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO2) nanoparticles via dopamine‐induced polymerization are additively manufactured into an orthopedic implant through material extrusion (ME). The exterior of the PEEK/TiO2 composite is coated with hydroxyapatite (HA) using radiofrequency (RF) magnetron sputtering to increase both the strength and biocompatibility provided by homogeneous ceramic–ceramic interactions and the protuberant nanoscale topography between the internal TiO2 nanoparticle reinforcement and external HA coating. The hardness, tensile, and compression, and scratch test results demonstrate a considerable enhancement in the mechanical strength of the hierarchical PEEK/TiO2/HA hybrid composite structure compared to that of the conventional 3D‐printed PEEK. Furthermore, PEEK with internal TiO2 reinforcement improves the proliferation and differentiation of bone cells in vitro, whereas the external HA coating leads to a more prevalent osteoblast absorption. Micro‐computed tomography and histological analyses confirm new bone formation and a high bone‐to‐implant contact ratio on the HA‐coated PEEK structure reinforced with TiO2 nanoparticles.

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Curved Architected Triboelectric Metamaterials: Auxeticity‐Enabled Enhanced Figure‐of‐Merit

Chen,

Shi,

Akbarzadeh

2023

Adv Funct Materials

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Triboelectric generators are integrated into curved architected materials to realize triboelectric metamaterials that simultaneously harvest electricity from wasted mechanical energy and perform mechanical energy absorption. Novel triboelectric mechanical metamaterials (TMMs) of distance‐changing, angle‐changing, and mixed modes are designed, fabricated, and tested under a cyclic compressive load. The open‐circuit voltage and short‐circuit current of lightweight TMMs are found to be as high as 40 V and 10 nA. The introduced TMMs can effectively harvest energy under loadings from two distinctive directions. A theoretical model for predicting the energy harvesting properties of TMMs is developed, and the role of auxeticity on the energy harvesting figure‐of‐merit (FOMes) is elicited. The introduced TMMs exhibit enhanced FOMes enabled by a decrease in their negative Poisson's ratio and an increase in their resilience. The FOMes of curved architected TMMs surpasses by more than 16 times the FOMes of triboelectric materials with conventional architectures (i.e., triangular, quadrilateral, and hexagonal cell topologies). An intelligent skateboard with integrated TMMs is fabricated as a proof of concept to demonstrate motion sensing, shock‐absorbing, and energy harvesting functionalities of multimodal triboelectric metamaterials. The introduced design strategy for triboelectric metamaterials unlocks their applications in self‐powered and self‐monitoring sports equipment, smart soft robots, and large‐scale energy harvesters.

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Patient‐Specific Self‐Powered Metamaterial Implants for Detecting Bone Healing Progress (Adv. Funct. Mater. 32/2022)

Cited by 8 publications

References 0 publications

Applications of Triboelectric Nanogenerators in Bone Tissue Engineering

Applications of Triboelectric Nanogenerators in Bone Tissue Engineering

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Curved Architected Triboelectric Metamaterials: Auxeticity‐Enabled Enhanced Figure‐of‐Merit

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