2022
DOI: 10.1002/adfm.202206863
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Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Abstract: Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional implants are optimized for use either under high mechanical load or for active osseointegration. To achieve the dual target of mechanical durability and biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO2) nanoparticles via dopamine‐induced polymerization are additively manufactured into an orthopedic implant through material extrusion (ME). … Show more

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Cited by 37 publications
(17 citation statements)
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“…This mechanism prevents stress from passing through hydroxyapatite crystals, inhibiting crack propagation and ultimately enhancing the mechanical properties of the scaffold. 32,33 The results show that optimal osteoinductivity is achieved when the scaffold's pore size is controlled within the range of 200−500 μm, 34 and the porosity is maintained at 50−70%. 35 The hHAP/CS scaffolds with different concentration gradients, having pore sizes between 400 and 500 μm and porosity levels ranging from 50 to 80%, display favorable conditions.…”
Section: Discussionmentioning
confidence: 97%
“…This mechanism prevents stress from passing through hydroxyapatite crystals, inhibiting crack propagation and ultimately enhancing the mechanical properties of the scaffold. 32,33 The results show that optimal osteoinductivity is achieved when the scaffold's pore size is controlled within the range of 200−500 μm, 34 and the porosity is maintained at 50−70%. 35 The hHAP/CS scaffolds with different concentration gradients, having pore sizes between 400 and 500 μm and porosity levels ranging from 50 to 80%, display favorable conditions.…”
Section: Discussionmentioning
confidence: 97%
“…Hydroxyapatite (HA) is an important ceramic material for biomedical applications (Grossin, 2021; Jang, 2022; Ahn, 2021). The production of calcium phosphate scaffolds through SLS has been largely studied (Grossin, 2021) for orthopedic implants.…”
Section: Introductionmentioning
confidence: 99%
“…14 Among all the 3D printing techniques, direct ink writing (DIW) is the most widely used technique for 3D printing hydrogels. 15–17 Different from DIW-based 3D printing that generates 3D structures by directly extruding viscous inks from printing nozzles, digital light processing (DLP)-based 3D printing fabricates 3D structures by projecting digitalized ultraviolet (UV) patterns to trigger localized photopolymerization that converts a liquid polymer resin to a solid 3D structure. 18,19 Due to the capability of manufacturing hydrogel structures with extremely high geometric resolution and complexity, DLP-based 3D printing has been successfully used in biomedical applications such as tissue engineering, 20 central nervous system regeneration, 21 cell-seeding scaffolds 22 and others.…”
Section: Introductionmentioning
confidence: 99%