Patients’ ability to react before complex partial seizures

Gyimesi, Csilla; Fogarasi, András; Kovács, Norbert; Tóth, Vanda; Magalova, V.; Schulz, Reinhard; Ebner, A.; Janszky, J.

doi:10.1016/j.yebeh.2006.10.004

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…In the present study, the ARBS and the APR (independent of each other) showed a negative association with the secondary generalization. In our previous study we also found that the ARBS in TLE was associated with a lack of SGTCS (Gyimesi et al., 2007). In that study, we hypothesized that ARBS was associated with a more circumscribed region involved at seizure onset, since we found that ARBS was associated with a lateralized seizure onset and a better outcome after TLE surgery.…”

Section: Discussionmentioning

confidence: 73%

“…Because our previous study revealed that the ability to react before seizures (ARBS) was associated with a lack of SGTCS, this variable was also selected. Based on our previous study, reaction ability (such as the ARBS) before clinically objective focal‐onset seizures was considered to have been present if the patient was capable of pushing an alarm button immediately before or during the video‐EEG–taped seizure (Gyimesi et al., 2007). Pushing an alarm button is a clear, prearranged task for patients during video‐EEG, and patients are aware that this task is important for their presurgical evaluation.…”

Section: Methodsmentioning

confidence: 99%

“…Because SGTCS is a poor prognostic factor for epilepsy surgery, we cannot exclude patients with poor surgical outcomes because this means exclusion of exactly those patients who typically have SGTCS. Therefore, concentrating only on postoperatively seizure‐free patients would have been a bias in this study because some variables including SGTCS are associated with poor surgical prognosis in TLE (Bengzon et al., 1968; Blume et al., 1994; Hennessy et al., 2000; Janszky et al., 2005), whereas others like ARBS indicate a good surgical prognosis (Gyimesi et al., 2007). Consequently, the localization and lateralization of epileptic focus was based on the epileptogenic lesion and on the decision of the presurgical team that decided to perform surgery based on reviewing the clinical data including MRI, interictal EEG, ictal video‐EEG, and patient history.…”

Section: Limitationsmentioning

confidence: 99%

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Secondarily generalized seizures in temporal lobe epilepsy

et al. 2012

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SUMMARYPurpose: Secondarily generalized tonic-clonic seizure (SGTCS) may occur rarely in temporal lobe epilepsy (TLE), but SGTCS is the major risk factor for sudden death and for seizure-related fatal injuries. Our aim was to investigate clinical factors associated with the occurrence of SGTCS in TLE by addressing two questions: (1) What clinical features differentiate patients with TLE who regularly had SGTCS from those who did not? (2) Is there an association of secondarily generalized seizures with preceding seizure elements and clinical data? Methods: We included 171 patients with TLE (mean age 34.4 ± 10) who participated in our presurgical evaluation program, which included continuous video-electroencephalography (EEG) and magnetic resonance imaging (MRI). Patients had a temporal lobectomy as a result of mesial or neocortical TLE. To reevaluate the archived seizures, we selected the consecutively recorded seizures of each patient. If the patient had more than three recorded seizures, then we reevaluated only the first three. Altogether video-recorded seizures of 402 patients were reanalyzed. Key Findings: A positive association between the presence of hippocampal sclerosis on the MRI and SGTCS in the patient history was found, whereas ictal speech and pedal automatism showed a negative association with a SGTCS history. The age of patients showed a positive association, whereas patient's reactivity before and during the seizure, oral/pedal automatisms, and vocalizations showed a negative association with secondary generalization of a focal-onset seizure during video-EEG monitoring. Significance: Clinical features associated with SGTCS may help clinicians during presurgical monitoring identify high-risk patients for SGTCS. Our study may help in understanding the pathophysiology of secondary generalization.

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Section: Discussionmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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Secondarily generalized seizures in temporal lobe epilepsy

et al. 2012

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“…A majority (>80%) of individuals with subclinical seizures and auras were free of complex partial seizures after surgery, whereas a minority (29%) of patients without subclinical seizures and auras became free of complex partial seizures 12 . In another study, the authors reviewed video recordings of 130 adult patients who had undergone epilepsy surgery for intractable medial temporal lobe epilepsy 13 . All patients were instructed to push the alarm button when they felt an aura.…”

Section: Discussionmentioning

confidence: 99%

“…Patients who did not push the alarm button had more frequent secondarily generalized seizures. They concluded that the ability to react before a complex partial seizure is associated with a circumscribed region involved at seizure onset and spread, and with a better outcome postoperatively 13 .…”

Section: Discussionmentioning

confidence: 99%