Patients’ Experience and Perception of Hospital-Treated Clostridium difficile Infections: a Qualitative Study

Guillemin, Isabelle; Marrel, Alexia; Lambert, Jérémy; Beriot-Mathiot, Axelle; Doucet, Christelle; Kazoglou, Odysseas; Luxemburger, Christine; Reygrobellet, Camille; Arnould, B

doi:10.1007/s40271-013-0043-y

Cited by 27 publications

(47 citation statements)

References 20 publications

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“…In a recent study in 24 patients in the United States and France, which used semistructured interviews, respondents reported that CDI symptoms were associated with emotional distress, embarrassment, inability to participate in usual daily activities, and fear of recurrence [30]. These impacts on patients' lives highlight the importance of assessing CDI symptoms.…”

Section: Discussionmentioning

confidence: 99%

The CDI-DaySyms: Content Development of a New Patient-Reported Outcome Questionnaire for Symptoms of Clostridium difficile Infection

et al. 2018

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Section: Discussionmentioning

confidence: 99%

The CDI-DaySyms: Content Development of a New Patient-Reported Outcome Questionnaire for Symptoms of Clostridium difficile Infection

et al. 2018

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“…These types of emotions can cause patients to experience social isolation and anxieties. A study of 24 patients with CDI subjected to semi-structured interviews revealed similar emotional distress and extreme physical exhaustion that is associated with CDI [ 19 ]. The isolation and secrecy that we observed could be implicated in the limited sexual activity in the surveyed patients.…”

Section: Discussionmentioning

confidence: 99%

Patient Perspectives on Fecal Microbiota Transplantation for Clostridium Difficile Infection

et al. 2016

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IntroductionClostridium difficile infection (CDI) is a severe and increasingly frequent healthcare-associated infection that develops after disruption of the gut microbiota. Immunocompromised, hospitalized patients have an increased likelihood of acquiring CDI, leading to lengthened hospital stays, increased medical fees, and higher rates of morbidity and mortality. Treatment of CDI is challenging because of limited treatment options and a 19–20% recurrence rate. Thus, there is a need for effective, affordable and safe treatments for CDI. Fecal microbiota transplantation (FMT) is the transplantation of donor stool into the intestine of a CDI patient to restore the structure and function of the gut microbiota and eradicate CDI. Recently, FMT has become an attractive alternative treatment for CDI due to its overwhelming success rate. However, the patient perspective on the effect of CDI and the role of FMT in that context is lacking.MethodsWe undertook a patient survey to gather qualitative and quantitative data on the short-term social, physical, emotional outcomes for patients with CDI who have undergone FMT.ResultsWe found in all patients interviewed that the social implications of CDI were generally more severe than the emotional and physical aspects.ConclusionFuture studies should consider evaluating these important patient-centered factors as outcomes. Moreover, patients are willing to undergo FMT as treatment for CDI.

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“…Several studies have already been published on CDI patient's quality of life, using different methodologies. Among them, we can cite Madeo et al [14] and Guillemin et al [15] which were among the first studies to explore the perception and experience of CDI patients. They were performed on a limited number of patients (n = 15 and n = 24 respectively) and used a qualitative approach (interviews of patients with open-ended questions).…”

Section: Introductionmentioning

confidence: 99%

Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey

Lurienne

Bandinelli

Galvain

et al. 2020

J Patient Rep Outcomes

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Background: Although the incidence, severity and mortality of Clostridioides (Clostridium) difficile infection (CDI) have been increasing, patients' quality of life changes resulting from CDI have not been studied thoroughly. This study aimed at exploring the consequences of CDI on quality of life through patients' perspective. Methods: An observational, cross-sectional study involving 350 participants with a self-reported CDI diagnosis was conducted through an online self-administered survey. Participants were grouped into those who had active disease ("Current CDI") and those who had a history of CDI ("Past CDI"). Results: One hundred fifteen participants (33%) reported Current CDI and 235 (67%) reported Past CDI. A large majority of participants admitted that their daily activities were impacted by the infection (93.9% and 64.7% of Current and Past CDI respondents respectively, p < 0.05). Physical and psychological consequences of CDI were experienced by 63.5% and 66.1% of participants with active CDI. Despite the infection being cleared, these consequences were still frequently experienced in Past CDI cohort with similar rates (reported by 73.2% of respondents for both, physical consequences p = 0.08; psychological consequences p = 0.21). After the infection, 56.6% of respondents noted that post-CDI symptoms remained; 40.9% believed they would never get rid of them. Conclusions: While the societal burden of CDI is well described in the literature, our study is one of the first aimed at understanding the major burden of CDI on quality of life. Our results highlight the long-lasting nature of CDI and further reinforce the need for enhanced therapeutics in the prevention and treatment of this devastating infection.

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Patients’ Experience and Perception of Hospital-Treated Clostridium difficile Infections: a Qualitative Study

Cited by 27 publications

References 20 publications

The CDI-DaySyms: Content Development of a New Patient-Reported Outcome Questionnaire for Symptoms of Clostridium difficile Infection

The CDI-DaySyms: Content Development of a New Patient-Reported Outcome Questionnaire for Symptoms of Clostridium difficile Infection

Patient Perspectives on Fecal Microbiota Transplantation for Clostridium Difficile Infection

Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey

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