Patients' perception of DED and its relation with time to diagnosis and quality of life: an international and multilingual survey

Labétoulle, Marc; Rolando, Maurizio; Baudouin, Christophe; Setten, Gysbert van

doi:10.1136/bjophthalmol-2016-309193

Cited by 29 publications

(22 citation statements)

References 23 publications

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“…Likewise, the results confirm H2 because a longer time to diagnosis is related to lower QL levels. This result is in line with a previous research (Labetoulle et al., ; Vasquez et al., ). Finally, in our study, the type of lupus (systemic or cutaneous) was shown not to be related to the QL in these patients; therefore, we could not accept H3, similar to a previous study (Reis et al., ).…”

Section: Discussionsupporting

confidence: 94%

“…Therefore, an early diagnosis is associated with a lower impact on the QL in patients with chronic diseases. Unfortunately, it is common for patients with immune diseases to remain undiagnosed for a long time, which is associated with a decrease in the QL of these patients (Batalla et al., ; Labetoulle, Rolando, Baudouin, & Van Setten, ). In the case of lupus, there are few studies that analyse the importance of time to diagnose on the QL (Batalla et al.,).…”

Section: Introductionmentioning

confidence: 99%

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The relations of quality of life in patients with lupus erythematosus: Regression models versus qualitative comparative analysis

Rioja

Valero‐Moreno

Giménez-Espert

et al. 2019

Journal of Advanced Nursing

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Background Lupus erythematosus (LE) is an autoimmune disease that can have negative repercussions on the quality of life (QL) of those who suffer from it. The QL can be influenced by socio‐demographic factors are related to the disease itself. Aims To analyse the associative power of socio‐demographic (age and sex) and medical variables (type of lupus, diagnostic time and symptomatically associated with lupus) on the QL in patients with lupus by comparing linear relations models and models based on comparative qualitative fuzzy analysis. Design This is a retrospective cross‐sectional design. Participants The sample consisted of 161 patients (88.4% female) diagnosed with LE between the ages of 18–66 years. Methods Data were collected between 2015 ‐ 2017 using the Lupus Erythematosus Quality of Life Questionnaire. Two different statistical methodologies were used: traditional regression models and qualitative comparative analysis models of fuzzy sets. Results The results of the regression model suggest that none of the variables considered could explain the QL of these patients. On the other hand, the results of the fuzzy models suggest that being female, young and a shorter time to diagnosis explain higher levels of QL in these types of patients. Conclusions Since nurses are the people who interact most with patients, detecting risk groups of patients with lupus respect to their QL. This can help develop intervention programs from a nursing perspective.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The relations of quality of life in patients with lupus erythematosus: Regression models versus qualitative comparative analysis

Rioja

Valero‐Moreno

Giménez-Espert

et al. 2019

Journal of Advanced Nursing

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“…Country-specific data on the patient experience of DED are particularly sparse. Nevertheless, a recent cross-sectional survey of 706 patients with DED from five European countries (France, Germany, Italy, Spain and the UK) provided some insight into regional perspectives 19. In this survey, more patients in France considered DED to be a ‘handicap’ (21%) compared with the overall percentages for all countries (12%, p<0.05).…”

Section: Discussionmentioning

confidence: 83%

Comparing the needs and preferences of patients with moderate and severe dry eye symptoms across four countries

et al. 2019

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Background/aimsUnderstanding patients’ perspectives of their disease can inform drug development and treatment decisions. In this study, we compared the preferences and needs of patients with moderate and severe dry eye symptoms from four different countries.MethodsA quantitative questionnaire was developed based on the self-explicated conjoint methodology and was administered to 160 patients with moderate or severe dry eye disease (DED) from Australia, Germany, UK and the USA.ResultsPatients with moderate dry eye symptoms ranked ‘treatment satisfaction’ as the most important aspect, whereas ‘symptom bother’ was more relevant for those in the severe group. Both the moderate and severe groups classified treatment effectiveness as the most important treatment attribute. This result was consistent across the four countries, although US patients gave significantly higher scores than patients from other countries (p<0.001). Furthermore, patients from Australia ranked ‘treatment experience’ as significantly more important than the concern of side effects, whereas respondents from Germany exhibited the opposite trend (p<0.05 for both). The health burden of DED is reflected in the average European Quality of Life-5 Dimensions 5-level (EQ-5D) scores of 0.764 and 0.658 for patients with moderate and severe disease, respectively.ConclusionOur results confirm that across the countries in the study, moderate and severe DED has a major impact on patients’ quality of life and daily activities. By providing insight into the patient perspective of DED, our study helps identify outcomes that are important to patients and may guide future drug development and clinical decision-making.

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“…Symptoms of DED are of varying severity and were described as stinging, burning or scratchy sensations, foreign-body sensation, increased sensitivity to light, blurred vision, as well as eye fatigue and eye redness. 67 In DED, ocular surface inflammation, paralleled or not by tissue damage, results in changes in nerve structure and altered responses to external mechanical or chemical stimuli. The peripheral and central sensitization results in a pain response to normally non-painful stimuli.…”

Section: The Cationic Emulsions For Dry Eye Managementmentioning

confidence: 99%

Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease

Daull

Amrane

Ismail

et al. 2020

Journal of Ocular Pharmacology and Therapeutics

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Dry eye disease (DED) is a complex multifactorial disease that affects an increasing number of patients worldwide. Close to 30% of the population has experienced dry eye (DE) symptoms and presented with some signs of the disease during their lifetime. The significant heterogeneity in the medical background of patients with DEs and in their sensitivity to symptoms renders a clear understanding of DED complicated. It has become evident over the past few years that DED results from an impairment of the ocular surface homeostasis. Hence, a holistic treatment approach that concomitantly addresses the different mechanisms that result in the destabilization of the tear film (TF) and the ocular surface would be appropriate. The goal of the present review is to compile the different types of scientific evidence (from in silico modeling to clinical trials) that help explain the mechanism of action of cationic emulsion (CE)-based eye drop technology for the treatment of both the signs and the symptoms of DED. These CEbased artificial tear (AT) eye drops designed to mimic, from a functional point of view, a healthy TF contribute to the restoration of a healthy ocular surface environment and TF that leads to a better management of DE patients. The CE-based AT eye drops help restore the ocular surface homeostasis in patients who have unstable TF or no tears.

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Patients' perception of DED and its relation with time to diagnosis and quality of life: an international and multilingual survey

Cited by 29 publications

References 23 publications

The relations of quality of life in patients with lupus erythematosus: Regression models versus qualitative comparative analysis

The relations of quality of life in patients with lupus erythematosus: Regression models versus qualitative comparative analysis

Comparing the needs and preferences of patients with moderate and severe dry eye symptoms across four countries

Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease

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