Introduction: Depression is a term used to describe a health problem in which mood pattern will be affected. Clinical depression is more severe and the symptoms can continue for weeks, months, and even years in some cases if it is not treated and it does interfere with our ability to function and it also can leads to suicide at its worst. Although clinical guidelines recommend antidepressants be continued for at least 6 months after symptom remission, approximately one third of patients discontinue antidepressants within the first month of treatment, and 44% discontinue them by the third month of treatment. Adherence to antidepressants is a stimulating problem in the management of patients with depression. Various factors such as nature and duration of therapy, disease characteristics, medication side-effects, cost of treatment, characteristics of health service facilities, the relation among the physician and patient, patient characteristics such as socioeconomic factors, patient's perspective about the illness and treatment have been reported to influence adherence.