Patients with chronic rhinosinusitis and obstructive sleep apnea have                     increased paroxysmal limb movement

Mahdavinia, Mahboobeh; Hui, Jessica; Zitun, Mohamed; Lastra, Alejandra; Herdegen, James J.; Codispoti, Christopher D.; Khan, Rafsa; LoSavio, Phillip; Batra, Pete S.

doi:10.1177/1945892418762843

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…However, how sleep architecture is modified during this process remains unclear. Another study by Mahdavinia et al [35] demonstrated an increased periodic limb movement index in patients with CRS with OSA. In sleep fragmentation-exposed mice, plasma IL-6 levels and the number of macrophages were elevated, [36] suggesting the role of inflammatory conditions in sleep discontinuity of OSA.…”

Section: Discussionmentioning

confidence: 91%

Relationships between chronic rhinosinusitis without nasal polyps and obstructive sleep apnea in male patients: a cross-sectional study

Wang

Zhang

Cheng

et al. 2022

Preprint

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Purpose: Patients with chronic rhinosinusitis (CRS) often have sleep impairments, and this issue is closely related to obstructive sleep apnea (OSA). However, research using objective examinations to evaluate sleep quality in inpatients with CRS is lacking. This study aimed to explore the sleeping characteristics of CRS without nasal polyps (CRSsNP) when comorbid with OSA using polysomnography (PSG). Methods: For this cross-sectional, single-center study, we recruited 147 adult male inpatients diagnosed with CRSsNP between March 2019 and April 2020. OSA was diagnosed using standard PSG. The patients were classified into two groups according to their apnea–hypopnea index value: CRSsNP with OSA and CRSsNP without OSA. Demographic features and sleep parameters were evaluated and compared between the groups. Results: Inpatients with CRSsNP had a high risk of OSA (61.2%). The CRSsNP with OSA group had a higher prevalence of obesity, slept for less time, and were more easily aroused during sleep ( P < 0.001, P = 0.002, and P = 0.001, respectively) than the CRSsNP without OSA group. Logistic regression analysis revealed that patients with CRSsNP and comorbid OSA had a higher risk of microarousal, with an odds ratio (OR) of 1.037 (95% confidence interval [CI]: 1.007–1.068). This association remained significant, even after adjusting for age and body mass index (OR: 1.037, 95% CI: 1.002–1.074; P = 0.036). Conclusions: Patients with CRSsNP had poor sleep quality and a high risk of OSA. An exaggerated sleeping discontinuity exists in patients with CRSsNP.

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Section: Discussionmentioning

confidence: 91%

Relationships between chronic rhinosinusitis without nasal polyps and obstructive sleep apnea in male patients: a cross-sectional study

Wang

Zhang

Cheng

et al. 2022

Preprint

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“…53 It has also been posited that chronic post-nasal drainage associated with sino-nasal inflammation can induce inflammatory, obstructive changes in the upper airway including the soft palate and uvula. 52 OSA is not known to be as common in adults as in the pediatric population with CF. In a cross-sectional study with 51 stable CF adults (mean age 25.1 years), only two CF patients (3.9%) met the standard criteria for OSA.…”

Section: Obstructive Sleep Apnea (Osa)mentioning

confidence: 98%

“…They compared patients with both CRS and OSA to patients with OSA and without CRS, and found that the AHI (Apnea-Hypopnea Index )between the two groups was similar suggesting that CRS may not significantly impact AHI. 52 The effect of CRS, if any, on OSA has been theorized to be related to increased nasal airway resistance and sequelae of chronic inflammation. 53 It has also been posited that chronic post-nasal drainage associated with sino-nasal inflammation can induce inflammatory, obstructive changes in the upper airway including the soft palate and uvula.…”

Section: Obstructive Sleep Apnea (Osa)mentioning

confidence: 99%

Sleep- Disordered Breathing in Cystic Fibrosis

Jobanputra

Jagpal

Ahmed

et al. 2020

Preprint

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Sleep-disordered breathing is an underrecognized comorbidity in the cystic fibrosis (CF) population across the lifespan. Nocturnal hypoxia, obstructive sleep apnea (OSA), and nocturnal hypoventilation are respiratory abnormalities that occur commonly during sleep, and have deleterious consequences to quality of life in people with CF. Effective screening for these abnormalities is needed to allow for the timely initiation of treatment. Lack of treatment leads to worse pulmonary, cardiovascular, and metabolic outcomes in patients. In this review, we give an overview of sleep-disordered breathing for the CF clinician, including definitions, treatment, and suggestions for future research. We strongly encourage the CF community to incorporate evaluation for sleep-disordered breathing, so that outcomes for the subset of the patients with coexisting sleep-disordered breathing improve.

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“…Mahdavinia et al examined how CRS affects PSG findings in patients with comorbid OSA. They compared patients with both CRS and OSA to patients with OSA and without CRS, and found that the AHI between the two groups was similar suggesting that CRS may not significantly impact AHI 83 . The effect of CRS, if any, on OSA has been theorized to be related to increased nasal airway resistance and sequelae of chronic inflammation 84 .…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

“…The effect of CRS, if any, on OSA has been theorized to be related to increased nasal airway resistance and sequelae of chronic inflammation 84 . It has also been posited that chronic post‐nasal drainage associated with sino‐nasal inflammation can induce inflammatory, obstructive changes in the upper airway including the soft palate and uvula 83 …”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Sleep‐disordered breathing in cystic fibrosis

Jagpal

Jobanputra

Ahmed

et al. 2021

Pediatric Pulmonology

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Sleep‐disordered breathing (SDB) is an under recognized comorbidity in the cystic fibrosis (CF) population across the lifespan. Nocturnal hypoxemia, obstructive sleep apnea, and nocturnal hypoventilation are respiratory abnormalities that occur commonly during sleep in patients with lung disease, and have deleterious consequences to the quality of life in people with CF. Effective screening for these abnormalities is needed to allow for timely initiation of treatment, which has been reported to be efficacious. Lack of treatment leads to worsened pulmonary, cardiovascular, and metabolic outcomes in patients. In this review, we give an overview of SDB for the CF clinician, including prevalence, treatment, and suggestions for future research. We strongly encourage the CF community to incorporate evaluation for SDB in CF clinical care so that outcomes for the subset of the CF patients with comorbid SDB improve.

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Patients with chronic rhinosinusitis and obstructive sleep apnea have increased paroxysmal limb movement

Abstract: Patients with CRS developed OSA at a lower BMI; patients CRS and OSA had similar sleep-related breathing patterns but higher risks for PLMs compared with patients with OSA and without CRS.

Cited by 13 publications

References 16 publications

Relationships between chronic rhinosinusitis without nasal polyps and obstructive sleep apnea in male patients: a cross-sectional study

Relationships between chronic rhinosinusitis without nasal polyps and obstructive sleep apnea in male patients: a cross-sectional study

Sleep- Disordered Breathing in Cystic Fibrosis

Sleep‐disordered breathing in cystic fibrosis

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